Association of Stress, Glucocorticoid Receptor, and FK506 Binding Protein Gene Polymorphisms With Internalizing Disorders Among HIV-Infected Children and Adolescents From Kampala and Masaka Districts-Uganda.

FKBP5 NR3C1 anxiety children depression internalizing disorders stress

Journal

Frontiers in pediatrics
ISSN: 2296-2360
Titre abrégé: Front Pediatr
Pays: Switzerland
ID NLM: 101615492

Informations de publication

Date de publication:
2021
Historique:
received: 10 02 2021
accepted: 21 09 2021
entrez: 12 11 2021
pubmed: 13 11 2021
medline: 13 11 2021
Statut: epublish

Résumé

Children and adolescents living with human immunodeficiency virus (CA-HIV) suffer a considerable burden of internalizing disorders (IDs; depressive and anxiety disorders). Environmental and genetic factors have been reported to influence the vulnerability to IDs in western settings; however, their role among African populations remains inadequately explored. We investigated the individual and interactive effects of stress and single-nucleotide polymorphisms within the FK506 binding protein 5 (rs1360780) and glucocorticoid receptor (rs10482605) genes on ID status in a cohort of CA-HIV in Uganda. We genotyped rs10482605 (309 cases and 315 controls) and rs1360780 (350 cases and 335 controls) among CA-HIV with and without IDs using Kompetitive Allele-Specific PCR. Socio-demographic variables, as well as allele and genotype distributions, were compared between cases and controls using chi-square tests. Genotypes were assessed for Hardy-Weinberg equilibrium. Composite indices of recent and chronic stress classes were also generated. A hierarchical cluster analysis was used to generate cutoff points within each of the indices of recent and chronic stress. Logistic regression was used to assess the association between IDs and each of recent stress, chronic stress, and the investigated genotypes. The interaction effect of chronic/recent stress on the association between each of the polymorphisms and IDs was determined using a likelihood ratio test. We observed no significant association between IDs and rs1360780 and rs10482605 polymorphisms within the FKBP5 and glucocorticoid receptor genes, respectively (

Identifiants

DOI: 10.3389/fped.2021.666426 PMID: 34765574 PMC: PMC8576357
pubmed: 34765574
doi: 10.3389/fped.2021.666426
pmc: PMC8576357
doi:

Types de publication

Journal Article

Langues

eng

Pagination

666426

Subventions

Organisme : Wellcome Trust
ID : 205069/Z/16/Z
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UP_1204/10
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/L004623/1
Pays : United Kingdom

Informations de copyright

Copyright © 2021 Owalla, Ssebajjwe, Muhanguzi, Womersley, Kinyanda and Kalungi.

Déclaration de conflit d'intérêts

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Tonny Jimmy Owalla (TJ)

Mental Health Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Med Biotech Laboratories, Kampala, Uganda.

Wilber Joseph Ssebajjwe (WJ)

Mental Health Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.

Dennis Muhanguzi (D)

Department of Bio-Molecular Resources and Bio-Laboratory Sciences, College of Veterinary Medicine, Animal Resources and Biosecurity, Makerere University, Kampala, Uganda.

Jacqueline Samantha Womersley (JS)

Department of Psychiatry, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
South African Medical Research Council, Stellenbosch University Genomics of Brain Disorders Research Unit, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.

Eugene Kinyanda (E)

Mental Health Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Department of Psychiatry, College of Health Sciences, Makerere University, Kampala, Uganda.

Allan Kalungi (A)

Mental Health Unit, Medical Research Council/Uganda Virus Research Institute and London School of Hygiene and Tropical Medicine Uganda Research Unit, Entebbe, Uganda.
Department of Immunology and Microbiology, College of Health Sciences, Makerere University, Kampala, Uganda.

Classifications MeSH