Longitudinal SARS-CoV-2 mRNA Vaccine-Induced Humoral Immune Responses in Patients with Cancer.

2019-nCoV Vaccine mRNA-1273 Adult Aged Antibodies, Viral BNT162 Vaccine COVID-19 / epidemiology Female Humans Immunity, Humoral Immunization Programs Immunoglobulin G Longitudinal Studies Male Middle Aged Neoplasms / complications Prospective Studies SARS-CoV-2 Surveys and Questionnaires Time Factors Vaccination / methods

Journal

Cancer research
ISSN: 1538-7445
Titre abrégé: Cancer Res
Pays: United States
ID NLM: 2984705R

Informations de publication

Date de publication:
15 12 2021
Historique:
received: 19 10 2021
revised: 08 11 2021
accepted: 08 11 2021
pubmed: 12 11 2021
medline: 8 1 2022
entrez: 11 11 2021
Statut: ppublish

Résumé

Longitudinal studies of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine-induced immune responses in patients with cancer are needed to optimize clinical care. In a prospective cohort study of 366 (291 vaccinated) patients, we measured antibody levels [anti-spike (IgG-(S-RBD) and anti-nucleocapsid immunoglobulin] at three time points. Antibody level trajectories and frequency of breakthrough infections were evaluated by tumor type and timing of treatment relative to vaccination. IgG-(S-RBD) at peak response (median = 42 days after dose 2) was higher (

Identifiants

DOI: 10.1158/0008-5472.CAN-21-3554 PMID: 34759001 PMC: PMC9060668
pubmed: 34759001
pii: 0008-5472.CAN-21-3554
doi: 10.1158/0008-5472.CAN-21-3554
pmc: PMC9060668
mid: NIHMS1757562
doi:

Substances chimiques

Antibodies, Viral 0
Immunoglobulin G 0
2019-nCoV Vaccine mRNA-1273 EPK39PL4R4
BNT162 Vaccine N38TVC63NU

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6273-6280

Subventions

Organisme : NIH HHS
ID : K26 OD010945
Pays : United States
Organisme : NCRR NIH HHS
ID : K26 RR026099
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS095894
Pays : United States
Organisme : NCI NIH HHS
ID : U54 CA260591
Pays : United States

Informations de copyright

©2021 The Authors; Published by the American Association for Cancer Research.

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Auteurs

Jane C Figueiredo (JC)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California. Jane.Figueiredo@cshs.org Karen.Reckamp@cshs.org Akil.Merchant@cshs.org.
ORCID: 0000-0001-8040-3341

Noah M Merin (NM)

Division of Hematology and Cellular Therapy, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Omid Hamid (O)

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, California.
ORCID: 0000-0002-8238-4655

So Yung Choi (SY)

Biostatistics and Bioinformatics Research Center, Cedars-Sinai Medical Center, Los Angeles, California.

Tucker Lemos (T)

Division of Hematology and Cellular Therapy, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Wendy Cozen (W)

Division of Hematology/Oncology, Department of Medicine, Department of Pathology, School of Medicine, University of California Irvine, Orange, California.
ORCID: 0000-0003-3415-8247

Nathalie Nguyen (N)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Laurel J Finster (LJ)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.
ORCID: 0000-0002-5974-8860

Joslyn Foley (J)

Division of Hematology and Cellular Therapy, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Justin Darrah (J)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Jun Gong (J)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Ronald Paquette (R)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Alain C Mita (AC)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Robert Vescio (R)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Inderjit Mehmi (I)

The Angeles Clinic and Research Institute, A Cedars-Sinai Affiliate, Los Angeles, California.
ORCID: 0000-0002-2253-2206

Reva Basho (R)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California.

Warren G Tourtellotte (WG)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Carissa A Huynh (CA)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Gil Y Melmed (GY)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.

Jonathan Braun (J)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.
ORCID: 0000-0003-1646-2974

Dermot P B McGovern (DPB)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.

Emebet Mengesha (E)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.
ORCID: 0000-0001-7830-1557

Greg Botwin (G)

F. Widjaja Foundation Inflammatory Bowel and Immunobiology Research Institute, Los Angeles, California.

John C Prostko (JC)

Abbott Diagnostics, Lake Forest, Illinois.

Edwin C Frias (EC)

Abbott Diagnostics, Lake Forest, Illinois.

James L Stewart (JL)

Abbott Diagnostics, Lake Forest, Illinois.

Sandy Joung (S)

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Jennifer Van Eyk (J)

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Advanced Clinical Biosystems Research Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Joseph E Ebinger (JE)

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Susan Cheng (S)

Department of Cardiology, Smidt Heart Institute, Cedars-Sinai Medical Center, Los Angeles, California.

Kimia Sobhani (K)

Department of Pathology and Laboratory Medicine, Cedars-Sinai Medical Center, Los Angeles, California.

Karen L Reckamp (KL)

Department of Medicine, Division of Medical Oncology, Cedars-Sinai Medical Center, Los Angeles, California. Jane.Figueiredo@cshs.org Karen.Reckamp@cshs.org Akil.Merchant@cshs.org.
ORCID: 0000-0002-9213-0325

Akil Merchant (A)

Division of Hematology and Cellular Therapy, Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California. Jane.Figueiredo@cshs.org Karen.Reckamp@cshs.org Akil.Merchant@cshs.org.

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