Optimal Management of Patients with Advanced or Metastatic Cholangiocarcinoma: An Evidence-Based Review.
chemotherapy
cholangiocarcinoma
detectable mutations
molecular
targeted therapy
Journal
Cancer management and research
ISSN: 1179-1322
Titre abrégé: Cancer Manag Res
Pays: New Zealand
ID NLM: 101512700
Informations de publication
Date de publication:
2021
2021
Historique:
received:
19
06
2021
accepted:
18
09
2021
entrez:
5
11
2021
pubmed:
6
11
2021
medline:
6
11
2021
Statut:
epublish
Résumé
Cholangiocarcinomas are rare tumors originating at any point along the biliary tree. These tumors often pose significant challenges for diagnosis and treatment, and often carry a poor prognosis. However, in recent years, studies have identified significant molecular heterogeneity with up to 50% of tumors having detectable mutations, leading to the guideline recommendations for molecular testing as part of the diagnostic workup for these tumors. In addition, better classification of these tumors and understanding of their biology has led to new drugs being approved for treatment of this resistant tumor. This manuscript will provide a comprehensive review of the epidemiology, risk factors, diagnostic approach, molecular classification, and treatment options for patients with advanced cholangiocarcinomas.
Identifiants
pubmed: 34737637
doi: 10.2147/CMAR.S276104
pii: 276104
pmc: PMC8558827
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
8085-8098Informations de copyright
© 2021 Ioffe et al.
Déclaration de conflit d'intérêts
Dr Efrat Dotan reports grants and/or personal fees from Pfizer, Lilly, Incyte, AstraZeneca, MedImmune, Boston Biomedical (SDP), QED, and Basilea, outside the submitted work. The authors report no other conflicts of interest in this work.
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