Relationship between body composition, exercise capacity and health-related quality of life in idiopathic pulmonary fibrosis.
clinical epidemiology
equipment evaluations
exercise
interstitial fibrosis
Journal
BMJ open respiratory research
ISSN: 2052-4439
Titre abrégé: BMJ Open Respir Res
Pays: England
ID NLM: 101638061
Informations de publication
Date de publication:
10 2021
10 2021
Historique:
received:
28
06
2021
accepted:
18
10
2021
entrez:
29
10
2021
pubmed:
30
10
2021
medline:
31
12
2021
Statut:
ppublish
Résumé
Bioelectrical impedance analysis (BIA) can be used to estimate Fat-Free Mass Index (FFMI). However, the use of directly measured BIA variables, such as phase angle (PhA), has gained attention. The frequency of low FFMI and PhA and its associations with exercise capacity and health-related quality of life (HRQL) in patients with idiopathic pulmonary fibrosis (IPF) have been scarcely studied. To investigate the frequency of low FFMI and PhA and their associations with exercise capacity and HRQL in patients with IPF. Patients underwent assessment of lung function, body composition, exercise capacity by the 6 min walk distance (6MWD), and HRQL by the Medical Outcomes Study Short-Form 36-item Questionnaire (SF-36). Patients were classified as presenting normal or low PhA or FFMI, accordingly to the 10th percentiles of age-sex-body mass index (BMI)-specific reference values. 98 patients (84 males, age: 68±8 years, forced vital capacity: 64%±18%predicted) were included. 24 patients presented low PhA. They were characterised by worse lung function, exercise capacity and HRQL compared with patients with normal PhA. 10 patients presented low FFMI, but despite differences in body composition, no differences were found between these patients and patients with normal FFMI. In a single regression analysis, age, lung function and body composition variables (except FFMI) were related to 6MWD and SF-36 Physical Summary Score (R²=0.06-0.36, p<0.05). None of the variables were related to SF-36 Mental Summary Score. One-fourth of the patients with IPF with normal to obese BMI present abnormally low PhA. Patients classified as low PhA presented worse lung function, exercise capacity and HRQL.
Identifiants
pubmed: 34711642
pii: 8/1/e001039
doi: 10.1136/bmjresp-2021-001039
pmc: PMC8557280
pii:
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© Author(s) (or their employer(s)) 2021. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.
Déclaration de conflit d'intérêts
Competing interests: None declared.
Références
Eur J Clin Nutr. 2017 Nov;71(11):1336-1340
pubmed: 28901331
Age Ageing. 1994 May;23(3):182-4
pubmed: 8085500
Respiration. 2014;88(5):378-88
pubmed: 25341682
Chest. 2019 Jun;155(6):1148-1157
pubmed: 30659818
Clin Nutr. 2015 Dec;34(6):1245-50
pubmed: 25597016
Chest. 2000 Jun;117(6):1627-32
pubmed: 10858394
Respir Res. 2019 Mar 12;20(1):56
pubmed: 30866948
BMC Pulm Med. 2017 Jul 25;17(1):104
pubmed: 28743305
Respiration. 2021;100(5):379-386
pubmed: 33721868
Am J Respir Crit Care Med. 2011 May 1;183(9):1231-7
pubmed: 21131468
BMC Cancer. 2010 Mar 09;10:86
pubmed: 20214798
Pulm Circ. 2016 Mar;6(1):30-6
pubmed: 27076905
Sci Rep. 2018 Sep 19;8(1):14074
pubmed: 30232390
Eur Respir Rev. 2020 Nov 5;29(158):
pubmed: 33153990
J Am Med Dir Assoc. 2015 Feb;16(2):173.e17-22
pubmed: 25499428
Eur Respir J. 2000 Dec;16(6):1050-5
pubmed: 11292104
Am J Respir Crit Care Med. 2002 Jul 1;166(1):111-7
pubmed: 12091180
Respir Med. 2015 Jul;109(7):914-22
pubmed: 25956020
Arch Phys Med Rehabil. 2016 May;97(5):788-97
pubmed: 26869288
Eur Respir Rev. 2012 Dec 1;21(126):355-61
pubmed: 23204124
Am J Respir Crit Care Med. 2014 Jan 15;189(2):214-22
pubmed: 24160862
Ann N Y Acad Sci. 1999 Apr 20;873:94-8
pubmed: 10372155
JPEN J Parenter Enteral Nutr. 2006 Jul-Aug;30(4):309-16
pubmed: 16804128
Eur Respir J. 2014 May;43(5):1421-9
pubmed: 24311766
Am J Respir Crit Care Med. 2013 Oct 15;188(8):e13-64
pubmed: 24127811
BMJ Open Respir Res. 2021 Oct;8(1):
pubmed: 34711642
Eur Respir J. 1999 Aug;14(2):270-4
pubmed: 10515400
Am J Respir Crit Care Med. 2011 Mar 15;183(6):788-824
pubmed: 21471066
Eur Respir J. 2005 Jul;26(1):153-61
pubmed: 15994402
Clin Nutr. 2004 Oct;23(5):1226-43
pubmed: 15380917
J Am Med Dir Assoc. 2014 Jun;15(6):448.e1-6
pubmed: 24755478
Nutr Clin Pract. 2021 Aug;36(4):891-898
pubmed: 33786852
Thorax. 2005 Jul;60(7):588-94
pubmed: 15994268
Intern Med. 2007;46(18):1533-42
pubmed: 17878639
Respirology. 2017 Apr;22(3):480-485
pubmed: 27868303
Clin Nutr. 2012 Dec;31(6):854-61
pubmed: 22698802