Evidence of reduced peripheral microvascular function in young Black women across the menstrual cycle.
passive leg movement
premenopausal women
racial disparity
vascular function
Journal
Journal of applied physiology (Bethesda, Md. : 1985)
ISSN: 1522-1601
Titre abrégé: J Appl Physiol (1985)
Pays: United States
ID NLM: 8502536
Informations de publication
Date de publication:
01 12 2021
01 12 2021
Historique:
pubmed:
29
10
2021
medline:
27
1
2022
entrez:
28
10
2021
Statut:
ppublish
Résumé
Black women (BLW) have a higher prevalence of cardiovascular disease (CVD) morbidity and mortality compared with White women (WHW). A racial disparity in CVD risk has been identified early in life as young adult BLW demonstrate attenuated vascular function compared with WHW. Previous studies comparing vascular function between premenopausal WHW and BLW have been limited to the early follicular (EF) phase of the menstrual cycle, which may not reflect their vascular function during other menstrual phases. Therefore, we evaluated peripheral microvascular function in premenopausal WHW and BLW using passive leg movement (PLM) during three menstrual phases: EF, ovulation (OV), and mid-luteal (ML). We hypothesized that microvascular function would be augmented during the OV and ML phases compared with the EF phase in both groups, but would be attenuated in BLW compared with WHW at all three phases. PLM was performed on 26 apparently healthy premenopausal women not using hormonal contraceptives: 15 WHW (23 ± 3 yr), 11 BLW (24 ± 5 yr). There was a main effect of race on the overall change in leg blood flow (ΔLBF) (
Identifiants
pubmed: 34709068
doi: 10.1152/japplphysiol.00452.2021
pmc: PMC8714980
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
1783-1791Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL155764
Pays : United States
Organisme : NIH HHS
ID : NIH P20 GM113125
Pays : United States
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