Dissecting VEGF-induced acute versus chronic vascular hyperpermeability: Essential roles of dimethylarginine dimethylaminohydrolase-1.
Cardiovascular medicine
Molecular genetics
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Oct 2021
22 Oct 2021
Historique:
received:
30
10
2020
revised:
12
07
2021
accepted:
27
09
2021
entrez:
27
10
2021
pubmed:
28
10
2021
medline:
28
10
2021
Statut:
epublish
Résumé
Vascular endothelial cell growth factor (VEGF) is a key regulator of vascular permeability. Herein we aim to understand how acute and chronic exposures of VEGF induce different levels of vascular permeability. We demonstrate that chronic VEGF exposure leads to decreased phosphorylation of VEGFR2 and c-Src as well as steady increases of nitric oxide (NO) as compared to that of acute exposure. Utilizing heat-inducible VEGF transgenic zebrafish (
Identifiants
pubmed: 34703990
doi: 10.1016/j.isci.2021.103189
pii: S2589-0042(21)01157-3
pmc: PMC8521174
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103189Subventions
Organisme : NHLBI NIH HHS
ID : R01 HL140411
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL148339
Pays : United States
Informations de copyright
© 2021 The Authors.
Déclaration de conflit d'intérêts
The authors declare no competing interests.
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