Biological sciences
Immunology
Respiratory medicine
Journal
iScience
ISSN: 2589-0042
Titre abrégé: iScience
Pays: United States
ID NLM: 101724038
Informations de publication
Date de publication:
22 Oct 2021
22 Oct 2021
Historique:
received:
17
12
2020
revised:
25
05
2021
accepted:
21
09
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
RANTES is implicated in allergic asthma and in T cell-dependent clearance of infection. RANTES receptor family comprises CCR1, CCR3, and CCR5, which are G-protein-coupled receptors consisting of seven transmembrane helices. Infections with respiratory viruses like Rhinovirus cause induction of RANTES production by epithelial cells. Here, we studied the role of RANTES in the peripheral blood mononuclear cells in cohorts of children with and without asthma and validated and extended this study to the airways of adults with and without asthma. We further translated these studies to a murine model of asthma induced by house dust mite allergen in wild-type RANTES and CCR5-deficient mice. Here we show an unpredicted therapeutic role of RANTES in the resolution of allergen-induced asthma by orchestrating the transition of effector GATA-3+CD4+ T cells into immune-regulatory-type T cells and inflammatory eosinophils into resident eosinophils as well as increased IL-10 production in the lung.
Identifiants
pubmed: 34693221
doi: 10.1016/j.isci.2021.103163
pii: S2589-0042(21)01131-7
pmc: PMC8511896
doi:
Types de publication
Journal Article
Langues
eng
Pagination
103163Subventions
Organisme : NHLBI NIH HHS
ID : K01 HL146977
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL118455
Pays : United States
Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no competing interests.
Références
J Allergy Clin Immunol. 2020 Feb;145(2):666-678.e9
pubmed: 31445933
J Allergy Clin Immunol Pract. 2017 Jul - Aug;5(4):918-927
pubmed: 28689842
Am J Respir Crit Care Med. 2007 Dec 1;176(11):1059-60
pubmed: 18042659
J Infect Dis. 2008 Feb 1;197(3):382-9
pubmed: 18248302
Nat Immunol. 2002 Jun;3(6):499
pubmed: 12032557
Am J Respir Cell Mol Biol. 1994 Jun;10(6):587-93
pubmed: 8003337
J Allergy Clin Immunol. 2016 Jun;137(6):1898-1902.e7
pubmed: 26993036
Immunol Allergy Clin North Am. 2019 Aug;39(3):335-344
pubmed: 31284924
J Immunol. 1998 Jan 15;160(2):550-4
pubmed: 9551886
Nat Med. 2012 May 04;18(5):726-35
pubmed: 22561836
Thorax. 2002 Apr;57(4):328-32
pubmed: 11923551
Eur Respir J. 2017 Feb 2;49(2):
pubmed: 27836955
Sci Rep. 2019 Oct 30;9(1):15695
pubmed: 31666531
Nat Commun. 2017 Dec 1;8(1):1900
pubmed: 29196657
J Virol. 1998 Jun;72(6):4756-64
pubmed: 9573240
Am J Respir Crit Care Med. 2005 Feb 1;171(3):224-30
pubmed: 15502111
J Allergy Clin Immunol. 2017 Feb;139(2):692-694
pubmed: 27609657
J Immunol. 2011 Jan 1;186(1):284-90
pubmed: 21131420
Caspian J Intern Med. 2016 Winter;7(1):37-42
pubmed: 26958331
J Clin Invest. 2016 Sep 1;126(9):3279-95
pubmed: 27548519
Eur J Immunol. 2005 Jul;35(7):2061-70
pubmed: 15948214
Am J Respir Crit Care Med. 2010 Jun 1;181(11):1207-16
pubmed: 20224068
Eur J Immunol. 2011 Jul;41(7):1992-9
pubmed: 21480211
Nat Rev Immunol. 2013 Jan;13(1):9-22
pubmed: 23154224
Am J Respir Cell Mol Biol. 2001 Dec;25(6):707-16
pubmed: 11726396
Eur Respir J. 2006 May;27(5):908-12
pubmed: 16707391
Biol Chem. 2015 Nov;396(11):1181-97
pubmed: 26040008
Curr Opin Immunol. 1999 Dec;11(6):626-34
pubmed: 10631546
Nucleic Acids Res. 2015 Apr 20;43(7):e47
pubmed: 25605792
J Clin Invest. 1995 Jun;95(6):2644-51
pubmed: 7769104
Eur Respir J. 2021 May 6;57(5):
pubmed: 33303556
Am J Respir Cell Mol Biol. 2006 Aug;35(2):147-54
pubmed: 16528011
J Immunol. 2003 Nov 15;171(10):5498-506
pubmed: 14607956
PLoS One. 2012;7(2):e32110
pubmed: 22355412
J Immunol. 1999 Jul 1;163(1):165-73
pubmed: 10384113
Am J Respir Cell Mol Biol. 2002 May;26(5):594-601
pubmed: 11970912
PLoS One. 2015 Jun 26;10(6):e0131451
pubmed: 26115403
Medicine (Baltimore). 2020 Jul 17;99(29):e20953
pubmed: 32702834
N Engl J Med. 1998 Feb 12;338(7):436-45
pubmed: 9459648
J Allergy Clin Immunol. 2019 Feb;143(2):669-680.e12
pubmed: 29778505
Mucosal Immunol. 2015 May;8(3):464-75
pubmed: 25807184
Clin Exp Allergy. 2004 Aug;34(8):1314-20
pubmed: 15298575
J Clin Lab Anal. 1998;12(3):137-44
pubmed: 9591699
Nat Rev Immunol. 2017 Dec;17(12):746-760
pubmed: 28891557
J Allergy Clin Immunol. 2010 Apr;125(4):803-13
pubmed: 20371394
Nat Immunol. 2002 Feb;3(2):196-200
pubmed: 11812998
J Leukoc Biol. 2001 Jun;69(6):977-85
pubmed: 11404385
J Immunol. 2008 Aug 1;181(3):1917-26
pubmed: 18641329
Nat Protoc. 2006;1(6):2870-5
pubmed: 17406546
Mucosal Immunol. 2016 Sep;9(5):1183-92
pubmed: 26732679
Pediatr Allergy Immunol. 2018 Jun;29(4):383-393
pubmed: 29512854
Immunol Today. 1998 Dec;19(12):568-74
pubmed: 9864948
Inflamm Allergy Drug Targets. 2012 Dec;11(6):484-91
pubmed: 23078048
J Virol. 2006 Aug;80(16):8151-7
pubmed: 16873271