Physically Active Lifestyle Is Associated With Attenuation of Hippocampal Dysfunction in Cognitively Intact Older Adults.
aerobic exercise
functional connectivity
hippocampus
memory
neuroimaging
Journal
Frontiers in aging neuroscience
ISSN: 1663-4365
Titre abrégé: Front Aging Neurosci
Pays: Switzerland
ID NLM: 101525824
Informations de publication
Date de publication:
2021
2021
Historique:
received:
05
06
2021
accepted:
12
08
2021
entrez:
25
10
2021
pubmed:
26
10
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Alterations in hippocampal function have been shown in older adults, which are expressed as changes in hippocampal activity and connectivity. While hippocampal activation during memory demands has been demonstrated to decrease with age, some older individuals present increased activity, or hyperactivity, of the hippocampus which is associated with increased neuropathology and poor memory function. In addition, lower functional coherence between the hippocampus and core hubs of the default mode network (DMN), namely, the posteromedial and medial prefrontal cortices, as well as increased local intrahippocampal connectivity, were also demonstrated in cognitively intact older adults. Aerobic exercise has been shown to elicit neuroprotective effects on hippocampal structure and vasculature in aging, and improvements in cardiorespiratory fitness have been suggested to mediate these exercise-related effects. However, how these lifestyle factors relate to hippocampal function is not clear. Fifty-two cognitively intact older adults (aged 65-80 years) have been recruited and divided into physically active (
Identifiants
pubmed: 34690738
doi: 10.3389/fnagi.2021.720990
pmc: PMC8527880
doi:
Types de publication
Journal Article
Langues
eng
Pagination
720990Informations de copyright
Copyright © 2021 Eisenstein, Giladi, Hendler, Havakuk and Lerner.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Nat Neurosci. 1999 Mar;2(3):266-70
pubmed: 10195220
Neuron. 2007 Sep 6;55(5):697-711
pubmed: 17785178
Nat Neurosci. 2011 Jun;14(6):750-6
pubmed: 21532579
J Alzheimers Dis. 2015;43(1):19-22
pubmed: 25061047
Neurology. 2005 Aug 9;65(3):404-11
pubmed: 16087905
Lancet Neurol. 2005 Nov;4(11):705-11
pubmed: 16239176
J Neurosci. 2019 Oct 30;39(44):8788-8797
pubmed: 31541019
Neuron. 2010 Feb 25;65(4):550-62
pubmed: 20188659
J Neurosci. 2014 Jul 16;34(29):9506-15
pubmed: 25031394
Lancet Neurol. 2012 Dec;11(12):1048-56
pubmed: 23137948
J Exerc Rehabil. 2015 Apr 30;11(2):80-6
pubmed: 25960980
Science. 1991 Sep 20;253(5026):1380-6
pubmed: 1896849
Neurology. 2018 Jan 16;90(3):126-135
pubmed: 29282327
Cereb Cortex. 2012 Aug;22(8):1813-23
pubmed: 21945849
Proc Natl Acad Sci U S A. 2013 May 21;110(21):E1953-62
pubmed: 23620517
Eur J Neurosci. 2010 Jan;31(1):167-76
pubmed: 20092563
Neurobiol Aging. 2009 Jul;30(7):1114-24
pubmed: 18053618
Brain Behav Immun. 2013 Feb;28:90-9
pubmed: 23123199
Neurobiol Aging. 2010 Nov;31(11):1927-36
pubmed: 19062136
Neurotherapeutics. 2017 Jul;14(3):662-676
pubmed: 28560709
Front Mol Neurosci. 2019 Sep 25;12:229
pubmed: 31680849
Front Mol Neurosci. 2017 May 19;10:144
pubmed: 28579942
J Neurosci. 2019 Jan 16;39(3):548-556
pubmed: 30482786
Elife. 2019 Mar 22;8:
pubmed: 30900990
Neuroimage. 2008 Jun;41(2):286-301
pubmed: 18407525
Biol Psychiatry. 2010 Nov 15;68(10):894-902
pubmed: 20359695
Life Sci. 2019 Sep 1;232:116667
pubmed: 31326567
J Neurosci Res. 2004 May 1;76(3):356-62
pubmed: 15079864
Nat Commun. 2017 Oct 31;8(1):1214
pubmed: 29089479
Hippocampus. 2009 Oct;19(10):928-36
pubmed: 19212941
Neuroimage. 2016 May 1;131:155-61
pubmed: 26584869
J Gerontol A Biol Sci Med Sci. 2008 Jan;63(1):62-6
pubmed: 18245762
Brain Sci. 2020 Feb 08;10(2):
pubmed: 32046299
Brain Res Mol Brain Res. 1998 Oct 30;61(1-2):147-53
pubmed: 9795193
Front Aging Neurosci. 2010 Aug 26;2:
pubmed: 20890449
Annu Rev Neurosci. 2011;34:259-88
pubmed: 21456960
Neurobiol Aging. 2012 Feb;33(2):423.e15-25
pubmed: 21074901
Brain Imaging Behav. 2011 Sep;5(3):212-21
pubmed: 21607547
Ann Intern Med. 2006 Jan 17;144(2):73-81
pubmed: 16418406
Circulation. 2010 Jul 13;122(2):191-225
pubmed: 20585013
Neurology. 2009 Sep 15;73(11):854-61
pubmed: 19752452
Hum Brain Mapp. 2002 Nov;17(3):143-55
pubmed: 12391568
Neuroimage. 2004 Apr;21(4):1732-47
pubmed: 15050594
Hum Brain Mapp. 2012 Oct;33(10):2415-27
pubmed: 21898676
Nat Rev Neurosci. 2012 Oct;13(10):713-26
pubmed: 22992647
Hippocampus. 2009 Oct;19(10):913-27
pubmed: 19405143
Med Image Anal. 2001 Jun;5(2):143-56
pubmed: 11516708
Mol Psychiatry. 2015 May;20(5):585-93
pubmed: 25311366
Alzheimers Dement. 2010 Jul;6(4):303-11
pubmed: 19744893
Psychol Aging. 2008 Mar;23(1):104-18
pubmed: 18361660
J Neurol Neurosurg Psychiatry. 2007 Aug;78(8):812-8
pubmed: 17287238
Trends Cogn Sci. 2013 Oct;17(10):502-9
pubmed: 24018144
Neuroimage. 2016 May 1;131:81-90
pubmed: 26477656
Hippocampus. 2020 May;30(5):456-471
pubmed: 31589003
Elife. 2017 Feb 08;6:
pubmed: 28177283
Cereb Cortex. 2005 Nov;15(11):1676-89
pubmed: 15703252
Trends Cogn Sci. 2012 May;16(5):292-305
pubmed: 22542563
Hum Brain Mapp. 2009 Jan;30(1):13-23
pubmed: 17979117
Neuroimage. 2001 Dec;14(6):1370-86
pubmed: 11707093
Elife. 2015 Jan 13;4:
pubmed: 25584461
Neuroscience. 2005;133(3):853-61
pubmed: 15896913
Alzheimers Dement (N Y). 2019 Jun 07;5:208-215
pubmed: 31198839
Neurobiol Aging. 2012 Aug;33(8):1690-8
pubmed: 21741129
Neuroimage. 2002 Oct;17(2):825-41
pubmed: 12377157
Neuroimage Clin. 2019;23:101904
pubmed: 31254939
Neuroimage. 2016 May 1;131:133-41
pubmed: 26702778
Neuroimage. 2016 Jun;133:468-476
pubmed: 27034025
Neuroimage. 2009 Oct 15;48(1):63-72
pubmed: 19573611
PLoS One. 2013 May 17;8(5):e64318
pubmed: 23691195
Front Aging Neurosci. 2014 Apr 07;6:59
pubmed: 24778617
Ann Neurol. 2010 Dec;68(6):865-75
pubmed: 21194156
Neuroimage. 2003 Oct;20(2):1052-63
pubmed: 14568475
Hippocampus. 2021 Mar;31(3):305-320
pubmed: 33314497
Neuron. 2012 May 10;74(3):467-74
pubmed: 22578498
Cortex. 2015 Mar;64:352-62
pubmed: 25614233
Proc Natl Acad Sci U S A. 2009 Apr 28;106(17):7209-14
pubmed: 19357304
Brain Res. 2015 Sep 24;1621:82-101
pubmed: 25451089
J Neurol Neurosurg Psychiatry. 2003 Jan;74(1):44-50
pubmed: 12486265
Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):3017-22
pubmed: 21282661
Brain. 2015 Apr;138(Pt 4):1023-35
pubmed: 25678559
J Neurosci. 2005 Sep 21;25(38):8680-5
pubmed: 16177036
Nat Commun. 2019 Oct 25;10(1):4900
pubmed: 31653847
Hum Brain Mapp. 2001 Nov;14(3):129-39
pubmed: 11559958
Growth Factors. 2004 Sep;22(3):123-31
pubmed: 15518235
Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17654-9
pubmed: 25422457