Association between Severity of Diffuse Idiopathic Skeletal Hyperostosis and Ossification of Other Spinal Ligaments in Patients with Ossification of the Posterior Longitudinal Ligament.
cervical ossification of the posterior longitudinal ligament
diffuse idiopathic skeletal hyperostosis
grading system
multicenter study
whole-spine computed tomography
Journal
Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588
Informations de publication
Date de publication:
13 Oct 2021
13 Oct 2021
Historique:
received:
19
09
2021
revised:
09
10
2021
accepted:
10
10
2021
entrez:
23
10
2021
pubmed:
24
10
2021
medline:
24
10
2021
Statut:
epublish
Résumé
Although diffuse idiopathic skeletal hyperostosis (DISH) is known to coexist with the ossification of spinal ligaments (OSLs), details of the radiographic relationship remain unclear. We prospectively collected data of 239 patients with symptomatic cervical ossification of the posterior longitudinal ligament (OPLL) and analyzed the DISH severity on whole-spine computed tomography images, using the following grades: grade 0, no DISH; grade 1, DISH at T3-T10; grade 2, DISH at both T3-T10 and C6-T2 and/or T11-L2; and grade 3, DISH beyond C5 and/or L3. Ossification indices were calculated as the sum of vertebral and intervertebral levels with OSL for each patient. DISH was found in 107 patients (44.8%), 65 (60.7%) of whom had grade 2 DISH. We found significant associations of DISH grade with the indices for cervical OPLL (r = 0.45, The DISH grade correlated with the indices of OSL at each high-prevalence level as well as the whole spine.
Sections du résumé
BACKGROUND
BACKGROUND
Although diffuse idiopathic skeletal hyperostosis (DISH) is known to coexist with the ossification of spinal ligaments (OSLs), details of the radiographic relationship remain unclear.
METHODS
METHODS
We prospectively collected data of 239 patients with symptomatic cervical ossification of the posterior longitudinal ligament (OPLL) and analyzed the DISH severity on whole-spine computed tomography images, using the following grades: grade 0, no DISH; grade 1, DISH at T3-T10; grade 2, DISH at both T3-T10 and C6-T2 and/or T11-L2; and grade 3, DISH beyond C5 and/or L3. Ossification indices were calculated as the sum of vertebral and intervertebral levels with OSL for each patient.
RESULTS
RESULTS
DISH was found in 107 patients (44.8%), 65 (60.7%) of whom had grade 2 DISH. We found significant associations of DISH grade with the indices for cervical OPLL (r = 0.45,
CONCLUSION
CONCLUSIONS
The DISH grade correlated with the indices of OSL at each high-prevalence level as well as the whole spine.
Identifiants
pubmed: 34682814
pii: jcm10204690
doi: 10.3390/jcm10204690
pmc: PMC8539272
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
World Neurosurg. 2015 May;83(5):724-6
pubmed: 25661263
J Orthop Sci. 2019 Jan;24(1):30-34
pubmed: 30232028
Surg Neurol. 2000 May;53(5):427-31; discussion 431
pubmed: 10874140
Eur Spine J. 2011 Jul;20 Suppl 2:S195-201
pubmed: 20697749
J Orthop Sci. 2019 Jul;24(4):601-606
pubmed: 30679080
Radiology. 1989 Sep;172(3):835-9
pubmed: 2788894
Osteoporos Int. 2014 Mar;25(3):1089-98
pubmed: 23974860
Radiology. 1976 Jun;119(3):559-68
pubmed: 935390
Rheumatology (Oxford). 2018 Dec 1;57(12):2120-2128
pubmed: 30060244
J Orthop Sci. 2016 Jul;21(4):439-445
pubmed: 27183890
RMD Open. 2020 Feb;6(1):
pubmed: 32111653
Arthritis Care Res (Hoboken). 2018 Jan;70(1):145-152
pubmed: 28371491
Spine (Phila Pa 1976). 2016 Nov 1;41(21):1668-1676
pubmed: 27120057
J Orthop Sci. 2019 Jan;24(1):35-41
pubmed: 30243519
Spine (Phila Pa 1976). 2004 May 1;29(9):1006-10
pubmed: 15105673
PLoS One. 2016 Aug 22;11(8):e0160117
pubmed: 27548354
Global Spine J. 2021 Mar 10;:2192568221996300
pubmed: 33715508
Asian Spine J. 2017 Feb;11(1):63-70
pubmed: 28243371
Clin Spine Surg. 2018 Nov;31(9):E460-E465
pubmed: 30113323
BMC Musculoskelet Disord. 2019 May 25;20(1):253
pubmed: 31128588
Spine (Phila Pa 1976). 2020 Aug 15;45(16):E1006-E1012
pubmed: 32150133
BMC Musculoskelet Disord. 2016 Dec 1;17(1):492
pubmed: 27903251
Eur J Radiol. 1998 Jul;27(3):196-205
pubmed: 9717635
J Bone Miner Metab. 2015 Mar;33(2):221-9
pubmed: 24623190
Spine (Phila Pa 1976). 2013 Sep 1;38(19):E1216-22
pubmed: 24509558
Neurosurg Focus. 2011 Mar;30(3):E7
pubmed: 21434823
J Bone Joint Surg Am. 2001 Oct;83(10):1537-44
pubmed: 11679606
J Rheumatol. 1983 Dec;10(6):939-47
pubmed: 6420561
Curr Rheumatol Rep. 2009 Oct;11(5):321-8
pubmed: 19772826
Spine (Phila Pa 1976). 2012 Mar 1;37(5):E309-14
pubmed: 22146284
Eur Spine J. 2009 Feb;18(2):145-56
pubmed: 18791749
J Orthop Sci. 2017 Jan;22(1):38-42
pubmed: 27697426
Scand J Rheumatol. 1984;13(2):181-9
pubmed: 6740271