Brain MRI in SARS-CoV-2 pneumonia patients with newly developed neurological manifestations suggestive of brain involvement.
Journal
Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288
Informations de publication
Date de publication:
14 10 2021
14 10 2021
Historique:
received:
21
07
2021
accepted:
05
10
2021
entrez:
15
10
2021
pubmed:
16
10
2021
medline:
29
10
2021
Statut:
epublish
Résumé
The increased frequency of neurological manifestations, including central nervous system (CNS) manifestations, in patients with coronavirus disease 2019 (COVID-19) pandemic is consistent with the virus's neurotropic nature. In most patients, brain magnetic resonance imaging (MRI) is a sensitive imaging modality in the diagnosis of viral encephalitides in the brain. The purpose of this study was to determine the frequency of brain lesion patterns on brain MRI in severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pneumonia patients who developed focal and non-focal neurological manifestations. In addition, it will compare the impact of the Glasgow Coma Scale (GCS) as an index of deteriorating cerebral function on positive brain MRIs in both neurological manifestations. This retrospective study included an examination of SARS-CoV-2 pneumonia patients with real-time reverse transcription polymerase chain reaction (RT-PCR) confirmation, admitted with clinicoradiologic evidence of COVID-19 pneumonia, and who were candidates for brain MRI due to neurological manifestations suggesting brain involvement. Brain imaging acquired on a 3.0 T MRI system (Skyra; Siemens, Erlangen, Germany) with a 20-channel receive head coil. Brain MRI revealed lesions in 38 (82.6%) of the total 46 patients for analysis and was negative in the remaining eight (17.4%) of all finally enclosed patients with RT-PCR confirmed SARS-CoV-2 pneumonia. Twenty-nine (63%) patients had focal neurological manifestations, while the remaining 17 (37%) patients had non-focal neurological manifestations. The patients had a highly significant difference (p = 0.0006) in GCS, but no significant difference (p = 0.4) in the number of comorbidities they had. Brain MRI is a feasible and important imaging modality in patients with SARS-CoV-2 pneumonia who develop neurological manifestations suggestive of brain involvement, particularly in patients with non-focal manifestations and a decline in GCS.
Identifiants
pubmed: 34650073
doi: 10.1038/s41598-021-00064-5
pii: 10.1038/s41598-021-00064-5
pmc: PMC8516985
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
20476Informations de copyright
© 2021. The Author(s).
Références
Radiology. 2020 Aug;296(2):E119-E120
pubmed: 32228363
Crit Care. 2020 Jul 13;24(1):421
pubmed: 32660520
JAMA Neurol. 2020 Jul 2;:
pubmed: 32614385
AJNR Am J Neuroradiol. 2001 Sep;22(8):1561-5
pubmed: 11559506
Radiology. 2020 Nov;297(2):E270-E273
pubmed: 32437313
AJNR Am J Neuroradiol. 2020 Jul;41(7):1179-1183
pubmed: 32467191
N Engl J Med. 2017 Feb 9;376(6):584-594
pubmed: 28177862
Thromb Res. 2020 Jul;191:9-14
pubmed: 32353746
BMJ. 2020 Mar 26;368:m1091
pubmed: 32217556
N Engl J Med. 2020 Jun 4;382(23):2268-2270
pubmed: 32294339
JAMA Neurol. 2020 Jun 1;77(6):683-690
pubmed: 32275288
Virus Res. 2014 Dec 19;194:145-58
pubmed: 25281913
Cureus. 2020 Mar 21;12(3):e7352
pubmed: 32328364
Trends Microbiol. 2016 Jun;24(6):490-502
pubmed: 27012512
Radiology. 2020 Nov;297(2):E242-E251
pubmed: 32544034
Int J Infect Dis. 2020 May;94:55-58
pubmed: 32251791