Is equilibrium slurry pH a good surrogate for solid surface pH during drug dissolution?

Biopharmaceutics Drug Liberation Hydrogen-Ion Concentration Pharmaceutical Preparations Solubility
Computer simulation Equilibrium slurry pH Oral drug absorption Solid surface pH

Journal

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
ISSN: 1879-0720
Titre abrégé: Eur J Pharm Sci
Pays: Netherlands
ID NLM: 9317982

Informations de publication

Date de publication:
01 Jan 2022
Historique:
received: 10 08 2021
revised: 29 09 2021
accepted: 07 10 2021
pubmed: 13 10 2021
medline: 17 12 2021
entrez: 12 10 2021
Statut: ppublish

Résumé

The purpose of the present study was to investigate the suitability of equilibrium slurry pH (pH

Identifiants

DOI: 10.1016/j.ejps.2021.106037 PMID: 34637897
pubmed: 34637897
pii: S0928-0987(21)00340-7
doi: 10.1016/j.ejps.2021.106037
pii:
doi:

Substances chimiques

Pharmaceutical Preparations 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

106037

Informations de copyright

Copyright © 2021. Published by Elsevier B.V.

Auteurs

Taiga Uekusa (T)

Molecular Pharmaceutics Lab., College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan.

Alex Avdeef (A)

in-ADME Research, 1732 First Avenue, #102, New York, NY 10128, United States of America.

Kiyohiko Sugano (K)

Molecular Pharmaceutics Lab., College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1, Noji-higashi, Kusatsu, Shiga 525-8577, Japan. Electronic address: suganok@fc.ritsumei.ac.jp.

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Classifications MeSH

Recherchemedicale.com › Professions de santé › Pharmacologie › Biopharmacie › Is equilibrium slurry pH a good surrogate for...
Recherchemedicale.com › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Pharmacocinétique › Libération de médicament › Is equilibrium slurry pH a good surrogate for...
Recherchemedicale.com › Phénomènes chimiques › Concentration en ions d'hydrogène › Is equilibrium slurry pH a good surrogate for...
Recherchemedicale.com › Préparations pharmaceutiques › Is equilibrium slurry pH a good surrogate for...
Recherchemedicale.com › Phénomènes chimiques › Solubilité › Is equilibrium slurry pH a good surrogate for...