Interactions between dietary patterns and genetic factors in relation to incident dementia among 70-year-olds.

Alzheimer Disease / epidemiology Animals Apolipoprotein E4 / genetics Female Genotype Heterozygote Humans Male Proportional Hazards Models Risk Factors
Apolipoprotein E genotype Dementia Dietary pattern Nutrition Polygenic risk score

Journal

European journal of nutrition
ISSN: 1436-6215
Titre abrégé: Eur J Nutr
Pays: Germany
ID NLM: 100888704

Informations de publication

Date de publication:
Mar 2022
Historique:
received: 07 07 2021
accepted: 28 09 2021
pubmed: 12 10 2021
medline: 22 2 2022
entrez: 11 10 2021
Statut: ppublish

Résumé

To investigate potential interactions between dietary patterns and genetic factors modulating risk for Alzheimer's disease (AD) in relation to incident dementia. Data were derived from the population-based Gothenburg H70 Birth Cohort Studies in Sweden, including 602 dementia-free 70-year-olds (examined 1992-93, or 2000-02; 64% women) followed for incident dementia until 2016. Two factors from a reduced rank regression analysis were translated into dietary patterns, one healthy (e.g., vegetables, fruit, and fish) and one western (e.g., red meat, refined cereals, and full-fat dairy products). Genetic risk was determined by APOE ε4 status and non-APOE AD-polygenic risk scores (AD-PRSs). Gene-diet interactions in relation to incident dementia were analysed with Cox regression models. The interaction p value threshold was < 0.1. There were interactions between the dietary patterns and APOE ε4 status in relation to incident dementia (interaction p value threshold of < 0.1), while no evidence of interactions were found between the dietary patterns and the AD-PRSs. Those with higher adherence to a healthy dietary pattern had a reduced risk of dementia among ε4 non-carriers (HR: 0.77; 95% CI: 0.61; 0.98), but not among ε4 carriers (HR: 0.86; CI: 0.63; 1.18). Those with a higher adherence to the western dietary pattern had an increased risk of dementia among ε4 carriers (HR: 1.37; 95% CI: 1.05; 1.78), while no association was observed among ε4 non-carriers (HR: 0.99; CI: 0.81; 1.21). The results of this study suggest that there is an interplay between dietary patterns and APOE ε4 status in relation to incident dementia.

Identifiants

DOI: 10.1007/s00394-021-02688-9 PMID: 34632537 PMC: PMC8854136
pubmed: 34632537
doi: 10.1007/s00394-021-02688-9
pii: 10.1007/s00394-021-02688-9
pmc: PMC8854136
doi:

Substances chimiques

Apolipoprotein E4 0

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Pagination

871-884

Subventions

Organisme : hjärnfonden
ID : FO2020-0235
Organisme : swedish research council
ID : 2018-02532
Organisme : swedish research council
ID : 2017-00915
Organisme : alzheimerfonden
ID : AF-554461
Organisme : swedish research council for health, working life and wellfare
ID : AGECAP 2013-2300
Organisme : alzheimer's drug discovery foundation
ID : RDAPB-201809-2016615
Organisme : swedish research council for health, working life and wellfare
ID : 2018-00471
Organisme : the alzheimer's association zenith award
ID : ZEN-01-3151
Organisme : alzheimerfonden
ID : AF-844671
Organisme : alzheimer's drug discovery foundation
ID : 201809-2016862
Organisme : the alzheimerfonden
ID : AF-842 471
Organisme : swedish research council for health, working life and wellfare
ID : 2013-2496
Organisme : the swedish state under the agreement between the swedish government and the county councils, the alf-agreement
ID : ALF716681
Organisme : swedish research council
ID : 2007-7462
Organisme : hjärnfonden
ID : FO2019-0228
Organisme : swedish research council for health, working life and wellfare
ID : 2012-1138
Organisme : the swedish alzheimer foundation
ID : AF-939988
Organisme : instituto de pesquisa translacional em saúde e ambiente na região amazônica
ID : 1R01AG068398-01
Organisme : the ad strategic fund and the alzheimer's association
ID : ADSF-21-831377-C
Organisme : alzheimerfonden
ID : AF-647651
Organisme : swedish research council for health, working life and wellfare
ID : 2010-0870
Organisme : the ad strategic fund and the alzheimer's association
ID : ADSF-21-831376-C
Organisme : swedish research council for health, working life and wellfare
ID : 2006-0020
Organisme : swedish research council for health, working life and wellfare
ID : 2004-0150
Organisme : swedish research council
ID : 11267
Organisme : swedish research council
ID : 2005-8460
Organisme : NIA NIH HHS
ID : R01 AG068398
Pays : United States
Organisme : swedish research council
ID : 2019-01096
Organisme : the swedish state under the agreement between the swedish government and the county councils, the alf-agreement
ID : ALFGBG-715986
Organisme : the swedish state under the agreement between the swedish government and the county councils, the alf-agreement
ID : ALFGBG-81392
Organisme : swedish research council
ID : 2012-5041
Organisme : the swedish alzheimer foundation
ID : AF-930582
Organisme : hjärnfonden
ID : FO2019-0163
Organisme : hjärnfonden
ID : FO2016-0214
Organisme : swedish research council for health, working life and wellfare
ID : 2006-0596
Organisme : swedish research council for health, working life and wellfare
ID : 2004-0145
Organisme : the alzheimerfonden
ID : AF-939825
Organisme : swedish research council
ID : 2013-8717
Organisme : hjärnfonden
ID : FO2017-0243
Organisme : swedish state support for clinical research
ID : ALFGBG-720931
Organisme : the swedish alzheimer foundation
ID : AF-646061
Organisme : swedish research council
ID : 2015-02830
Organisme : the european research council
ID : 681712
Organisme : swedish research council for health, working life and wellfare
ID : 2013-1202
Organisme : the ad strategic fund and the alzheimer's association
ID : ADSF-21-831381-C
Organisme : the european union joint program for neurodegenerative disorders
ID : JPND2019-466-236
Organisme : the swedish alzheimer foundation
ID : AF-741361
Organisme : swedish research council for health, working life and wellfare
ID : 2001-2646
Organisme : the alzheimer's association stephanie b. overstreet scholars
ID : IIRG-00-2159
Organisme : swedish research council for health, working life and wellfare
ID : 2003-0234
Organisme : swedish research council for health, working life and wellfare
ID : 2008-1111
Organisme : hjärnfonden
ID : FO2014-0207
Organisme : the swedish alzheimer foundation
ID : AF-742881
Organisme : the swedish state under the agreement between the swedish government and the county councils, the alf-agreement
ID : ALFGBG-771071
Organisme : swedish research council
ID : NEAR 2017-00639
Organisme : swedish research council for health, working life and wellfare
ID : 2008-1229
Organisme : alzheimerfonden
ID : AF-930868
Organisme : alzheimerfonden
ID : AF-743701
Organisme : the alzheimerfonden
ID : AF-737641
Organisme : the european union's horizon 2020 research and innovation programme under the marie skłodowska-curie grant agreement
ID : No 860197
Organisme : hjärnfonden
ID : FO2018-0214
Organisme : alzheimerfonden
ID : AF-940139

Informations de copyright

© 2021. The Author(s).

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Auteurs

Jessica Samuelsson (J)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden. jessica.samuelsson@neuro.gu.se.
ORCID: 0000-0002-8891-6720

Jenna Najar (J)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

Ola Wallengren (O)

Clinical Nutrition Unit, Sahlgrenska University Hospital, Gothenburg, Sweden.

Silke Kern (S)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

Hanna Wetterberg (H)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.

Madeleine Mellqvist Fässberg (M)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.

Henrik Zetterberg (H)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
UK Dementia Research Institute at UCL, London, UK.
Department of Neurodegenerative Disease, UCL Institute of Neurology, London, UK.

Kaj Blennow (K)

Clinical Neurochemistry Laboratory, Sahlgrenska University Hospital, Mölndal, Sweden.
Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.

Lauren Lissner (L)

School of Public Health and Community Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.

Elisabet Rothenberg (E)

Faculty of Health Sciences, Kristianstad University, Kristianstad, Sweden.

Ingmar Skoog (I)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.
Region Västra Götaland, Sahlgrenska University Hospital, Psychiatry, Cognition and Old Age Psychiatry Clinic, Gothenburg, Sweden.

Anna Zettergren (A)

Neuropsychiatric Epidemiology Unit, Department of Psychiatry and Neurochemistry, Institute of Neuroscience and Physiology, Sahlgrenska Academy, Centre for Ageing and Health (AGECAP) at the University of Gothenburg, Wallinsgatan 6, 431 41, Mölndal, Sweden.

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Classifications MeSH

Recherchemedicale.com › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Interactions between dietary patterns and...
Recherchemedicale.com › Eucaryotes › Animaux › Interactions between dietary patterns and...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Lipoprotéines › Apolipoprotéines › Apolipoprotéines E › Apolipoprotéine E4 › Interactions between dietary patterns and...
Recherchemedicale.com › Phénomènes génétiques › Génotype › Interactions between dietary patterns and...
Recherchemedicale.com › Phénomènes génétiques › Génotype › Hétérozygote › Interactions between dietary patterns and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Interactions between dietary patterns and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Analyse de survie › Modèles des risques proportionnels › Interactions between dietary patterns and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Interactions between dietary patterns and...