Na
Endothelium
Hypertension
Inflammation
Osmolarity
Sodium
Journal
Heliyon
ISSN: 2405-8440
Titre abrégé: Heliyon
Pays: England
ID NLM: 101672560
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
received:
04
05
2021
revised:
27
08
2021
accepted:
26
09
2021
entrez:
11
10
2021
pubmed:
12
10
2021
medline:
12
10
2021
Statut:
epublish
Résumé
High-salt consumption contributes to the development of hypertension and is considered an independent risk factor for vascular remodelling, cardiac hypertrophy and stroke incidence. Alterations in NO production, inflammation and endothelial cell stiffening are considered now as plausible mediators of cardiovascular dysfunction. We studied early responses of endothelial cells (HUVEC) caused by a moderate increase in extracellular sodium concentration. Exposure of HUVEC to elevated sodium within the physiological range up to 24 h is accompanied by changes in monovalent cations fluxes and Na,K-ATPase activation, and, in turn, results in a significant decrease in the content of
Identifiants
pubmed: 34632152
doi: 10.1016/j.heliyon.2021.e08088
pii: S2405-8440(21)02191-5
pmc: PMC8488490
doi:
Types de publication
Journal Article
Langues
eng
Pagination
e08088Informations de copyright
© 2021 The Author(s).
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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