Circulating and Myocardial Cytokines Predict Cardiac Structural and Functional Improvement in Patients With Heart Failure Undergoing Mechanical Circulatory Support.
biomarkers
cardiac recovery
growth factors/cytokines
inflammation
left ventricular assist device
Journal
Journal of the American Heart Association
ISSN: 2047-9980
Titre abrégé: J Am Heart Assoc
Pays: England
ID NLM: 101580524
Informations de publication
Date de publication:
19 10 2021
19 10 2021
Historique:
pubmed:
2
10
2021
medline:
21
12
2021
entrez:
1
10
2021
Statut:
ppublish
Résumé
Background Recent prospective multicenter data from patients with advanced heart failure demonstrated that left ventricular assist device (LVAD) support combined with standard heart failure medications, induced significant cardiac structural and functional improvement, leading to high rates of LVAD weaning in selected patients. We investigated whether preintervention myocardial and systemic inflammatory burden could help identify the subset of patients with advanced heart failure prone to LVAD-mediated cardiac improvement to guide patient selection, treatment, and monitoring. Methods and Results Ninety-three patients requiring durable LVAD were prospectively enrolled. Myocardial tissue and blood were acquired during LVAD implantation, for measurement of inflammatory markers. Cardiac structural and functional improvement was prospectively assessed via serial echocardiography. Eleven percent of the patients showed significant reverse remodeling following LVAD support (ie, responders). Circulating tumor necrosis factor alpha, interleukin (IL)-4, IL-5, IL-6, IL-7, IL-13, and interferon gamma were lower in responders, compared with nonresponders (
Identifiants
pubmed: 34595931
doi: 10.1161/JAHA.120.020238
pmc: PMC8751895
doi:
Substances chimiques
Biomarkers
0
Cytokines
0
Tumor Necrosis Factor-alpha
0
Interferon-gamma
82115-62-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e020238Subventions
Organisme : NHLBI NIH HHS
ID : T32 HL007576
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL135121
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL132067
Pays : United States
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