Immunomodulatory Responses of Two Synthetic Peptides against
Salmonella enterica serovar Typhimurium
antimicrobial peptides
cytokines
inflammation
scorpion peptides
Journal
Molecules (Basel, Switzerland)
ISSN: 1420-3049
Titre abrégé: Molecules
Pays: Switzerland
ID NLM: 100964009
Informations de publication
Date de publication:
14 Sep 2021
14 Sep 2021
Historique:
received:
09
08
2021
revised:
03
09
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
12
11
2021
Statut:
epublish
Résumé
In vitro assays of phagocytic activity showed that the peptide Pin2[G] stimulates phagocytosis in BMDM cells from 0.15 to 1.25 μg/mL, and in RAW 264.7 cells at 0.31 μg/mL. In the same way, the peptide FA1 induced phagocytosis in BMDM cells from 1.17 to 4.69 μg/mL and in RAW 264.7 cells at 150 μg/mL. Cytokine profiles of uninfected RAW 264.7 showed that Pin2[G] increased liberation TNF (from 1.25 to 10 μg/mL) and MCP-1 (10 μg/mL), and FA1 also increased the release of TNF (from 18.75 to 75 μg/mL) but did not increase the liberation of MCP-1. In RAW 264.7 macrophages infected with
Identifiants
pubmed: 34577046
pii: molecules26185573
doi: 10.3390/molecules26185573
pmc: PMC8466354
pii:
doi:
Substances chimiques
Peptides
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : 303045
Organisme : Dirección General de Asuntos del Personal Académico, Universidad Nacional Autónoma de México
ID : IT200321
Organisme : Consejo Nacional de Ciencia y Tecnología
ID : Scholarship 700349
Organisme : CYTED Ciencia y Tecnología para el Desarrollo
ID : 219RT0573
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