Potential Salivary Markers for Differential Diagnosis of Crohn's Disease and Ulcerative Colitis.
Crohn’s disease
TNF-α
biomarkers
calprotectin
differential diagnosis
inflammatory bowel disease
myeloperoxidase
oral immunity
saliva
ulcerative colitis
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
09 Sep 2021
09 Sep 2021
Historique:
received:
05
08
2021
revised:
19
08
2021
accepted:
08
09
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
The properties of the saliva of patients with inflammatory bowel disease (IBD) are poorly recognized. Likewise, the diagnostic potential of saliva for differentiating various forms of IBD is largely unexplored. Therefore, we compared the concentrations of several parameters in unstimulated whole mixed saliva collected in a standardized manner from patients with active IBD unresponsive to conventional therapy. The samples were received from 27 patients with Crohn's disease (CD), 24 patients with ulcerative colitis (UC), and 51 healthy individuals. Compared to the controls, the salivary concentrations of S100A8/calprotectin, myeloperoxidase, and IgA were significantly decreased in both CD and UC patients. In addition, patients with UC had decreased levels of TNF-R1 and decreased catalase activity. Interestingly, the concentrations of myeloperoxidase and TNF-R1 showed a high differentiation potential for CD and UC (AUC = 0.690 and 0.672, respectively). All these findings are discussed in the context of host defense in the oral cavity, patients' prior treatment regimens, and smoking habits.
Identifiants
pubmed: 34575091
pii: life11090943
doi: 10.3390/life11090943
pmc: PMC8469159
pii:
doi:
Types de publication
Journal Article
Langues
eng
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