Acute and Delayed Doxorubicin-Induced Myocardiotoxicity Associated with Elevation of Cardiac Biomarkers, Depletion of Cellular Antioxidant Enzymes, and Several Histopathological and Ultrastructural Changes.
acute
antioxidant enzymes
delayed
doxorubicin
myocardiopathy
Journal
Life (Basel, Switzerland)
ISSN: 2075-1729
Titre abrégé: Life (Basel)
Pays: Switzerland
ID NLM: 101580444
Informations de publication
Date de publication:
27 Aug 2021
27 Aug 2021
Historique:
received:
14
07
2021
revised:
17
08
2021
accepted:
24
08
2021
entrez:
28
9
2021
pubmed:
29
9
2021
medline:
29
9
2021
Statut:
epublish
Résumé
Doxorubicin (DOX; Adricin) is an anthracycline antibiotic, which is an efficient anticancer chemotherapeutic agent that targets many types of adult and pediatric tumors, such as breast cancer, leukemia, and lymphomas. However, use of DOX is limited due to its cardiotoxic effects. This study sequentially investigated the mechanistic pathways of the cardiotoxic process of DOX in rats at different post-treatment periods using cumulative dose, which is used in therapeutic regimes. In this regard, 56 male albino rats were used for the experiment. The experimental animals were divided into seven groups (
Identifiants
pubmed: 34575029
pii: life11090880
doi: 10.3390/life11090880
pmc: PMC8467687
pii:
doi:
Types de publication
Journal Article
Langues
eng
Références
Chem Biol. 2010 May 28;17(5):421-33
pubmed: 20534341
Life (Basel). 2021 May 17;11(5):
pubmed: 34067554
Biochemistry. 1997 Sep 23;36(38):11293-7
pubmed: 9333325
Pharmacogenet Genomics. 2011 Jul;21(7):440-6
pubmed: 21048526
Biochem Pharmacol. 1980 Nov 1;29(21):3003-10
pubmed: 7458950
Life Sci. 2001 Jan 12;68(8):889-901
pubmed: 11213359
Exp Clin Cardiol. 2002 Spring;7(1):35-9
pubmed: 19644577
Cancer Res. 1992 Jan 1;52(1):194-201
pubmed: 1727379
Mol Cell Biochem. 2002 Mar;232(1-2):19-26
pubmed: 12030376
Am J Physiol Regul Integr Comp Physiol. 2020 May 1;318(5):R829-R842
pubmed: 32159365
Eur J Pharmacol. 2018 Jan 5;818:241-253
pubmed: 29074412
Circulation. 2007 Jul 31;116(5):506-14
pubmed: 17638931
Drugs. 1994 Feb;47(2):223-58
pubmed: 7512899
Cancer Res. 2001 Dec 1;61(23):8422-8
pubmed: 11731422
Am J Pathol. 1974 Dec;77(3):439-54
pubmed: 4432914
Free Radic Biol Med. 1997;22(1-2):287-305
pubmed: 8958154
J Clin Invest. 1980 Jan;65(1):128-35
pubmed: 7350193
Pharmacol Rep. 2009 Jan-Feb;61(1):154-71
pubmed: 19307704
Paediatr Drugs. 2005;7(2):67-76
pubmed: 15871628
Medicina (Kaunas). 2019 Jan 24;55(2):
pubmed: 30682878
Am J Physiol Heart Circ Physiol. 2006 Sep;291(3):H1273-80
pubmed: 16565313
Toxicology. 2006 Feb 1;218(2-3):164-71
pubmed: 16325981
Toxicol Sci. 2014 Jul;140(1):3-15
pubmed: 24675088
Tumori. 2010 May-Jun;96(3):460-4
pubmed: 20845809
J Biol Chem. 2001 Dec 14;276(50):47266-76
pubmed: 11579094
Cancer Cell Int. 2019 Jul 24;19:191
pubmed: 31367189
Toxicol Appl Pharmacol. 1978 Jun;44(3):605-16
pubmed: 684750
Environ Health Perspect. 1978 Oct;26:181-91
pubmed: 31282
Transl Res. 2012 Apr;159(4):252-64
pubmed: 22424429
Am J Physiol Heart Circ Physiol. 2004 Mar;286(3):H933-9
pubmed: 14766674
Biomed Pharmacother. 2010 Dec 31;:
pubmed: 21295435
BMC Pharmacol Toxicol. 2018 Jan 10;19(1):3
pubmed: 29321061
Toxicol Appl Pharmacol. 2002 Dec 15;185(3):218-27
pubmed: 12498738
Am J Cardiol. 2007 Apr 1;99(7):974-7
pubmed: 17398195
Eur J Cancer. 1996;32A Suppl 4:S21-5
pubmed: 8976818
Blood. 2007 Mar 1;109(5):1878-86
pubmed: 17119114
Proc Natl Acad Sci U S A. 2004 May 4;101(18):6975-80
pubmed: 15100413
Heart Fail Rev. 2018 Jan;23(1):109-122
pubmed: 28944400
Cardiology. 2010;115(2):155-62
pubmed: 20016174
Jpn J Cancer Res. 1989 Jan;80(1):89-94
pubmed: 2496064
Biochim Biophys Acta. 1997 Aug 22;1321(2):101-6
pubmed: 9332499
Cancer Chemother Pharmacol. 1991;28(5):365-9
pubmed: 1914080
J Clin Invest. 2014 Feb;124(2):617-30
pubmed: 24382354
Metabolomics. 2009 Dec;5(4):407-418
pubmed: 20046867
J Biol Chem. 1986 Mar 5;261(7):3060-7
pubmed: 3456345
Clin Chim Acta. 2003 Mar;329(1-2):39-51
pubmed: 12589964
Cancer Chemother Pharmacol. 1985;15(3):244-52
pubmed: 3863717
Cancer. 2003 Jun 1;97(11):2869-79
pubmed: 12767102
Arch Immunol Ther Exp (Warsz). 2009 Nov-Dec;57(6):435-45
pubmed: 19866340
Biochem J. 1990 Feb 1;265(3):865-70
pubmed: 2306220
Zhonghua Nei Ke Za Zhi. 1997 Dec;36(12):808-11
pubmed: 10451935
J Mol Cell Cardiol. 2012 Jun;52(6):1213-25
pubmed: 22465037
Curr Cardiol Rev. 2011 Nov;7(4):214-20
pubmed: 22758622
Sci Rep. 2017 Mar 16;7:44735
pubmed: 28300219
Pharmacol Rep. 2008 May-Jun;60(3):382-90
pubmed: 18622063
Biochem Biophys Res Commun. 1993 Aug 16;194(3):1044-50
pubmed: 8352762
Biochim Biophys Acta. 2014 Jan;1845(1):84-9
pubmed: 24361676
Cardiovasc Toxicol. 2007;7(2):101-7
pubmed: 17652813
Br J Pharmacol. 2018 Mar;175(5):763-781
pubmed: 29161764
Toxicology. 2010 May 27;271(3):115-21
pubmed: 20346999
Histol Histopathol. 2004 Oct;19(4):1101-8
pubmed: 15375752
J Am Assoc Lab Anim Sci. 2007 Jul;46(4):20-32
pubmed: 17645292
J Clin Oncol. 2005 Apr 20;23(12):2629-36
pubmed: 15837978
J Pathol. 2005 Dec;207(4):436-44
pubmed: 16278810
Redox Biol. 2020 Jan;29:101394
pubmed: 31790851
J Appl Toxicol. 2004 Jan-Feb;24(1):47-52
pubmed: 14745846
Cancer Res. 1983 Nov;43(11):5427-32
pubmed: 6616474