APE1/Ref-1 - One Target with Multiple Indications: Emerging Aspects and New Directions.

Apurinic/apyrimidinic endonuclease Chemotherapy-induced peripheral neuropathy Colitis Crohn’s Glycolysis IBD Inflammation Metabolism OXPHOS Redox effector factor 1 Redox signaling TCA cycle

Journal

Journal of cellular signaling
ISSN: 2692-0638
Titre abrégé: J Cell Signal
Pays: United States
ID NLM: 101767200

Informations de publication

Date de publication:
2021
Historique:
entrez: 24 9 2021
pubmed: 25 9 2021
medline: 25 9 2021
Statut: ppublish

Résumé

In the realm of DNA repair, base excision repair (BER) protein, APE1/Ref-1 (Apurinic/Apyrimidinic Endonuclease 1/Redox Effector - 1, also called APE1) has been studied for decades. However, over the past decade, APE1 has been established as a key player in reduction-oxidation (redox) signaling. In the review by Caston

Identifiants

pubmed: 34557865
pmc: PMC8457357
mid: NIHMS1729236

Types de publication

Journal Article

Langues

eng

Pagination

151-161

Subventions

Organisme : NCI NIH HHS
ID : R01 CA205166
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA231267
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA211098
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL143403
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA254110
Pays : United States
Organisme : NHLBI NIH HHS
ID : R01 HL140961
Pays : United States
Organisme : NEI NIH HHS
ID : R01 EY031939
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA167291
Pays : United States

Déclaration de conflit d'intérêts

Conflict of Interest MRK is a member of the Ocuphire medical advisory board and CSO and co-founder of Apexian Pharmaceuticals which licensed APX3330 and other APX compounds from Indiana University School of Medicine. Ocuphire Pharma licensed APX3330 for ocular and diabetes indications from Apexian Pharmaceuticals.

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Auteurs

Mahmut Mijit (M)

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Rachel Caston (R)

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Silpa Gampala (S)

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Melissa L Fishel (ML)

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Jill Fehrenbacher (J)

Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Mark R Kelley (MR)

Herman B Wells Center for Pediatric Research, Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pediatrics, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Pharmacology and Toxicology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Indiana University Simon Comprehensive Cancer Center, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.
Department of Biochemistry and Molecular Biology, Indiana University School of Medicine, 1044 W. Walnut, Indianapolis, IN 46202, USA.

Classifications MeSH