Changes in serum biomarkers of inflammation in bovine besnoitiosis.
Acetylcholinesterase
Acute-phase response
Adenosine deaminase
Albumin
Bovine besnoitiosis
Haptoglobin
Paraoxonase-1
Serological biomarkers
Journal
Parasites & vectors
ISSN: 1756-3305
Titre abrégé: Parasit Vectors
Pays: England
ID NLM: 101462774
Informations de publication
Date de publication:
22 Sep 2021
22 Sep 2021
Historique:
received:
02
04
2021
accepted:
02
09
2021
entrez:
23
9
2021
pubmed:
24
9
2021
medline:
15
12
2021
Statut:
epublish
Résumé
Acute and chronic besnoitiosis in extensive natural-service herds can have relevant effects in the health of bulls and negative consequences in their productive performance. Recent progress has been made in order to elucidate the pathogenesis of this disease. In this context, the study of biomarkers of inflammation in serum would contribute to gaining knowledge about the physiopathology of bovine besnoitiosis. Serological biomarkers could help in early diagnosis and prognosis, as seropositive bulls may have mild or severe testicular lesions. Herein, we have investigated the diagnostic and/or prognostic value of a panel of serum (serological) biomarkers related to inflammation, including total protein, globulin and albumin, haptoglobin (Hp), adenosine deaminase (ADA) paraoxonase-1 (PON-1) and acetylcholinesterase (AChE) in naturally and experimentally B. besnoiti-infected males classified according to different clinical phases of the disease (acute, chronic and subclinical besnoitiosis). Results showed a similar response pattern in these biomarkers for naturally and experimentally infected cattle, with a few relevant variations. Most significant changes occurred during the acute phase of infection, although significant changes in a few biomarkers were also observed during the chronic infection. Haptoglobin, albumin, PON-1 and ADA were identified as the biomarkers that showed changes of higher magnitude in the acute phase of the infection, whereas high total protein and globulin values were found in chronically infected cattle. We have described the changes of a panel of inflammatory biomarkers of acute and chronic bovine besnoitiosis. In summary, several biomarkers with promising diagnostic value have been identified. The biomarkers associated with acute infection are related to previously reported molecular biomarkers in testicular parenchyma of infected bulls and could help in the diagnosis of early infections and complement results from specific immunoglobulin M (IgM) detection.
Sections du résumé
BACKGROUND
BACKGROUND
Acute and chronic besnoitiosis in extensive natural-service herds can have relevant effects in the health of bulls and negative consequences in their productive performance. Recent progress has been made in order to elucidate the pathogenesis of this disease. In this context, the study of biomarkers of inflammation in serum would contribute to gaining knowledge about the physiopathology of bovine besnoitiosis. Serological biomarkers could help in early diagnosis and prognosis, as seropositive bulls may have mild or severe testicular lesions.
METHODS
METHODS
Herein, we have investigated the diagnostic and/or prognostic value of a panel of serum (serological) biomarkers related to inflammation, including total protein, globulin and albumin, haptoglobin (Hp), adenosine deaminase (ADA) paraoxonase-1 (PON-1) and acetylcholinesterase (AChE) in naturally and experimentally B. besnoiti-infected males classified according to different clinical phases of the disease (acute, chronic and subclinical besnoitiosis).
RESULTS
RESULTS
Results showed a similar response pattern in these biomarkers for naturally and experimentally infected cattle, with a few relevant variations. Most significant changes occurred during the acute phase of infection, although significant changes in a few biomarkers were also observed during the chronic infection. Haptoglobin, albumin, PON-1 and ADA were identified as the biomarkers that showed changes of higher magnitude in the acute phase of the infection, whereas high total protein and globulin values were found in chronically infected cattle. We have described the changes of a panel of inflammatory biomarkers of acute and chronic bovine besnoitiosis.
CONCLUSIONS
CONCLUSIONS
In summary, several biomarkers with promising diagnostic value have been identified. The biomarkers associated with acute infection are related to previously reported molecular biomarkers in testicular parenchyma of infected bulls and could help in the diagnosis of early infections and complement results from specific immunoglobulin M (IgM) detection.
Identifiants
pubmed: 34551803
doi: 10.1186/s13071-021-04991-0
pii: 10.1186/s13071-021-04991-0
pmc: PMC8459460
doi:
Substances chimiques
Biomarkers
0
Globulins
0
Haptoglobins
0
Acetylcholinesterase
EC 3.1.1.7
Aryldialkylphosphatase
EC 3.1.8.1
Adenosine Deaminase
EC 3.5.4.4
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
488Subventions
Organisme : Ministerio de Economía y Competitividad
ID : AGL-2016-75202-R and PID2019-103960RB-I00
Organisme : Community of Madrid
ID : PLATESA P2018/ BAA-4370
Informations de copyright
© 2021. The Author(s).
Références
Front Cell Infect Microbiol. 2020 May 15;10:218
pubmed: 32500038
Res Vet Sci. 2019 Jun;124:383-386
pubmed: 31075616
Vet Pathol. 2015 May;52(3):476-88
pubmed: 25096291
Vet Clin Pathol. 2005 Jun;34(2):85-99
pubmed: 15902658
PLoS One. 2020 Jan 28;15(1):e0228134
pubmed: 31990932
PLoS One. 2015 Mar 18;10(3):e0117954
pubmed: 25785999
Prog Neurobiol. 1997 Jul;52(4):283-94
pubmed: 9247966
Vet Rec. 2016 Jun 11;178(24):605-7
pubmed: 27288168
BMC Vet Res. 2015 Feb 14;11:35
pubmed: 25886463
Comp Immunol Microbiol Infect Dis. 2017 Oct;54:34-37
pubmed: 28915999
Theriogenology. 2016 Sep 15;86(5):1325-32
pubmed: 27264738
BMC Vet Res. 2015 Feb 13;11:32
pubmed: 25880447
Mol Aspects Med. 2020 Jun;73:100851
pubmed: 32660714
Molecules. 2020 Aug 25;25(17):
pubmed: 32854225
Am J Vet Res. 2012 Jan;73(1):34-41
pubmed: 22204286
Vet Rec. 2005 Aug 27;157(9):262-4
pubmed: 16127139
J Comp Pathol. 2016 Feb-Apr;154(2-3):150-6
pubmed: 26929158
BMC Vet Res. 2019 Jun 12;15(1):197
pubmed: 31189466
Parasitology. 2014 Sep;141(11):1419-35
pubmed: 24871877
Exp Parasitol. 2013 Oct;135(2):325-30
pubmed: 23912041
Parasitology. 2011 Feb;138(2):201-8
pubmed: 20809996
Vet Parasitol. 2020 May;281:109120
pubmed: 32361525
Transbound Emerg Dis. 2020 Jan;67(1):234-249
pubmed: 31483955
Parasitol Res. 2017 Apr;116(4):1383-1393
pubmed: 28283798
BMC Vet Res. 2020 Oct 12;16(1):384
pubmed: 33046093
Vet J. 2019 Aug;250:15-23
pubmed: 31383415
Vet Res. 2021 Jul 22;52(1):106
pubmed: 34294155
Parasit Vectors. 2020 Mar 2;13(1):113
pubmed: 32122380
Theriogenology. 1981 Nov;16(5):523-30
pubmed: 16725665
Ann Surg. 2003 Mar;237(3):319-34
pubmed: 12616115
Res Vet Sci. 2012 Oct;93(2):668-74
pubmed: 22000805
Theriogenology. 2017 Nov;103:117-122
pubmed: 28780482
Trends Parasitol. 2013 Aug;29(8):407-15
pubmed: 23830145
Prev Vet Med. 2013 May 1;109(3-4):327-33
pubmed: 23149306
Trop Anim Health Prod. 2016 Aug;48(6):1301-4
pubmed: 27154214
J Vet Intern Med. 2012 Nov-Dec;26(6):1470-5
pubmed: 23113812
Vet J. 2010 Jul;185(1):23-7
pubmed: 20621712
Res Vet Sci. 2001 Jun;70(3):233-8
pubmed: 11676619
J Parasitol. 2013 Jun;99(3):459-66
pubmed: 23327488