Cardiopulmonary exercise performance and factors associated with aerobic capacity in neuromuscular diseases.
Journal
Muscle & nerve
ISSN: 1097-4598
Titre abrégé: Muscle Nerve
Pays: United States
ID NLM: 7803146
Informations de publication
Date de publication:
12 2021
12 2021
Historique:
revised:
14
09
2021
received:
31
12
2020
accepted:
16
09
2021
pubmed:
23
9
2021
medline:
19
3
2022
entrez:
22
9
2021
Statut:
ppublish
Résumé
Aerobic deconditioning, due to lower levels of physical activity, could impact independence for people with neuromuscular conditions. We report the maximal cardiopulmonary response in a cohort of people with Charcot Marie Tooth disease type 1A (CMT 1A) and inclusion body myositis (IBM). We also explored potential predictors of aerobic capacity with measures of physical impairment and functional performance. Participants underwent maximal cardiopulmonary exercise testing (CPET) using a semi-recumbent cycle ergometer. Data were analyzed to determine the peak O Twenty-two people with CMT and 17 people with IBM were recruited. Both groups showed significantly lower VO Lower than predicted CPET variables were observed that were not explained by cardiopulmonary limitations or reduced effort, implicating peripheral factors in limiting the cycling task. Regression analysis implied prediction of VO2 peak by body fat percentage and 6-min walk distance. Six-minute walk distance could be a potential proxy measure of cardiopulmonary fitness.
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
683-690Subventions
Organisme : Department of Health
ID : PB-PG-0711-25151
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/K000608/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : G0601943
Pays : United Kingdom
Organisme : NINDS NIH HHS
ID : U54 NS065712
Pays : United States
Informations de copyright
© 2021 The Authors. Muscle & Nerve published by Wiley Periodicals LLC.
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