Characterization of Ferromagnetic Composite Implants for Tumor Bed Hyperthermia.
Cancer treatment
hyperthermia
induction heating
thermal ablation
tumor bed implant
Journal
IEEE transactions on magnetics
ISSN: 0018-9464
Titre abrégé: IEEE Trans Magn
Pays: United States
ID NLM: 100971385
Informations de publication
Date de publication:
Sep 2021
Sep 2021
Historique:
entrez:
20
9
2021
pubmed:
21
9
2021
medline:
21
9
2021
Statut:
ppublish
Résumé
Hyperthermia therapy (HT) is becoming a well-recognized method for the treatment of cancer when combined with radiation or chemotherapy. There are many ways to heat a tumor and the optimum approach depends on the treatment site. This study investigates a composite ferromagnetic surgical implant inserted in a tumor bed for the delivery of local HT. Heating of the implant is achieved by inductively coupling energy from an external magnetic field of sub-megahertz frequency. Implants are formed by mechanically filling a resected tumor bed with self-polymerizing plastic mass mixed with small ferromagnetic thermoseeds. Model implants were manufactured and then heated in a 35 cm diameter induction coil of our own design. Experimental results showed that implants were easily heated to temperatures that allow either traditional HT (39-45°C) or thermal ablation therapy (>50°C) in an external magnetic field with a frequency of 90 kHz and amplitude not exceeding 4 kA/m. These results agreed well with a numerical solution of combined electromagnetic and heat transfer equations solved using the finite element method.
Identifiants
pubmed: 34538882
doi: 10.1109/tmag.2021.3097915
pmc: PMC8443243
mid: NIHMS1734913
doi:
Types de publication
Journal Article
Langues
eng
Subventions
Organisme : NCI NIH HHS
ID : R41 CA239815
Pays : United States
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