Identification of mutations that cooperate with defects in B cell transcription factors to initiate leukemia.

Animals Gain of Function Mutation Genetic Testing Humans Loss of Function Mutation Mice Mutation PAX5 Transcription Factor / genetics Precursor B-Cell Lymphoblastic Leukemia-Lymphoma / genetics Sequence Analysis, RNA Signal Transduction Trans-Activators / genetics Transcription Factors / genetics Transposases / genetics

Journal

Oncogene
ISSN: 1476-5594
Titre abrégé: Oncogene
Pays: England
ID NLM: 8711562

Informations de publication

Date de publication:
10 2021
Historique:
received: 01 12 2020
accepted: 07 09 2021
revised: 25 08 2021
pubmed: 19 9 2021
medline: 31 12 2021
entrez: 18 9 2021
Statut: ppublish

Résumé

The transcription factors PAX5, IKZF1, and EBF1 are frequently mutated in B cell acute lymphoblastic leukemia (B-ALL). We demonstrate that compound heterozygous loss of multiple genes critical for B and T cell development drives transformation, including Pax5

Identifiants

DOI: 10.1038/s41388-021-02012-z PMID: 34535769 PMC: PMC8556320
pubmed: 34535769
doi: 10.1038/s41388-021-02012-z
pii: 10.1038/s41388-021-02012-z
pmc: PMC8556320
mid: NIHMS1739253
doi:

Substances chimiques

EBF1 protein, human 0
PAX5 Transcription Factor 0
PAX5 protein, human 0
Trans-Activators 0
Transcription Factors 0
Transposases EC 2.7.7.-
sleeping beauty transposase, human EC 2.7.7.-

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

6166-6179

Subventions

Organisme : NCI NIH HHS
ID : R21 CA216652
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA077598
Pays : United States
Organisme : NCI NIH HHS
ID : P50 CA100632
Pays : United States
Organisme : NCI NIH HHS
ID : R50 CA211249
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA232317
Pays : United States

Informations de copyright

© 2021. The Author(s), under exclusive licence to Springer Nature Limited.

Références

Nat Immunol. 2017 Jun;18(6):694-704
pubmed: 28369050
Cancer Res. 2007 Dec 1;67(23):11093-8
pubmed: 18056430
J Immunol. 2009 Nov 1;183(9):5582-92
pubmed: 19843942
Hematology Am Soc Hematol Educ Program. 2014 Dec 5;2014(1):174-80
pubmed: 25696852
Nature. 2007 Apr 12;446(7137):758-64
pubmed: 17344859
Oncogene. 2016 Jun 30;35(26):3454-64
pubmed: 26500062
Immunity. 2003 Jul;19(1):131-44
pubmed: 12871645
Cancer Discov. 2013 Oct;3(10):1156-71
pubmed: 23887393
Cancer Cell. 2018 May 14;33(5):937-948.e8
pubmed: 29681510
Cancer Res. 2018 Jan 15;78(2):326-337
pubmed: 29066513
Leukemia. 2019 Jul;33(7):1583-1597
pubmed: 30679796
Blood. 2009 Jan 1;113(1):154-64
pubmed: 18840713
Nat Genet. 2013 Oct;45(10):1226-1231
pubmed: 24013638
Cell. 1995 Oct 20;83(2):289-99
pubmed: 7585946
J Immunol. 2004 Apr 15;172(8):4770-8
pubmed: 15067053
Nature. 2000 Jan 13;403(6766):216-20
pubmed: 10646609
Cancer Res. 2019 Mar 1;79(5):905-917
pubmed: 30674530
Cancer Res. 2009 Oct 15;69(20):8150-6
pubmed: 19808965
Nature. 2008 May 1;453(7191):110-4
pubmed: 18408710
Nature. 1995 Jul 20;376(6537):263-7
pubmed: 7542362
Cancer Cell. 2016 Aug 8;30(2):229-242
pubmed: 27451907
Cancer Immunol Res. 2014 Sep;2(9):823-30
pubmed: 25187272
BMC Bioinformatics. 2013 Apr 15;14:128
pubmed: 23586463
J Exp Med. 2011 Jun 6;208(6):1135-49
pubmed: 21606506
Blood. 2015 Jun 25;125(26):4052-9
pubmed: 25838350
Immunity. 1996 Dec;5(6):537-49
pubmed: 8986714
BMC Cancer. 2015 Aug 13;15:585
pubmed: 26269126
Blood. 2004 Sep 15;104(6):1639-47
pubmed: 15073037
Leukemia. 2013 Apr;27(5):1146-54
pubmed: 23160449
Nat Immunol. 2021 Apr;22(4):460-470
pubmed: 33767425
Nature. 1995 Mar 2;374(6517):70-4
pubmed: 7870176
Genome Res. 2016 Jan;26(1):119-29
pubmed: 26553456
Mol Cell Biol. 1997 Oct;17(10):6014-22
pubmed: 9315660
BMC Bioinformatics. 2008 Dec 29;9:559
pubmed: 19114008
Biochem J. 2011 Jan 15;433(2):357-69
pubmed: 21087210
Cell. 1994 Dec 2;79(5):901-12
pubmed: 8001127
Nucleic Acids Res. 2016 Jul 8;44(W1):W90-7
pubmed: 27141961
Nature. 2013 Aug 22;500(7463):415-21
pubmed: 23945592
Lab Invest. 2021 Jun;101(6):701-718
pubmed: 33658609
N Engl J Med. 2009 Jan 29;360(5):470-80
pubmed: 19129520
BMC Cancer. 2016 Aug 02;16:582
pubmed: 27484466
N Engl J Med. 2014 Sep 11;371(11):1005-15
pubmed: 25207766

Auteurs

Lynn M Heltemes-Harris (LM)

Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.

Gregory K Hubbard (GK)

Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA.

Rebecca S LaRue (RS)

Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

Sarah A Munro (SA)

Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

Rendong Yang (R)

Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, 55455, USA.
The Hormel Institute, University of Minnesota Austin, Austin, MN, 55912, USA.
ORCID: 0000-0002-9512-2240

Christine M Henzler (CM)

Minnesota Supercomputing Institute, University of Minnesota, Minneapolis, MN, 55455, USA.

Timothy K Starr (TK)

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.
Department of Obstetrics, Gynecology and Women's Health, University of Minnesota, Minneapolis, MN, 55455, USA.
ORCID: 0000-0002-6308-3451

Aaron L Sarver (AL)

Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA.

Steven M Kornblau (SM)

Department of Leukemia, The University of Texas, M.D. Anderson Cancer Center, Houston, TX, USA.
ORCID: 0000-0002-5990-9548

Michael A Farrar (MA)

Center for Immunology, University of Minnesota, Minneapolis, MN, 55455, USA. farra005@umn.edu.
Masonic Cancer Center, University of Minnesota, Minneapolis, MN, 55455, USA. farra005@umn.edu.
Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis, MN, 55455, USA. farra005@umn.edu.
ORCID: 0000-0002-5569-0366

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Identification of mutations that cooperate...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Mutation gain de fonction › Identification of mutations that cooperate...
Recherchemedicale.com › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Services de médecine préventive › Services de diagnostic › Dépistage génétique › Identification of mutations that cooperate...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Identification of mutations that cooperate...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Mutation perte de fonction › Identification of mutations that cooperate...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Identification of mutations that cooperate...
Recherchemedicale.com › Phénomènes génétiques › Variation génétique › Mutation › Identification of mutations that cooperate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription PAX › Protéine activatrice spécifique des lymphocytes B › Identification of mutations that cooperate...
Recherchemedicale.com › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Leucémie lymphoïde › Leucémie-lymphome lymphoblastique à précurseurs B et T › Leucémie-lymphome lymphoblastique à précurseurs B › Identification of mutations that cooperate...
Recherchemedicale.com › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Analyse de séquence d'ARN › Identification of mutations that cooperate...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transduction du signal › Identification of mutations that cooperate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Protéines virales › Protéines virales régulatrices ou accessoires › Transactivateurs › Identification of mutations that cooperate...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Identification of mutations that cooperate...
Recherchemedicale.com › Enzymes et coenzymes › Enzymes › Transferases › Phosphotransferases › Nucleotidyltransferases › Transposases › Identification of mutations that cooperate...