Identification and Phenotypic Characterization of Hsp90 Phosphorylation Sites That Modulate Virulence Traits in the Major Human Fungal Pathogen
Candida albicans
Hsp90
drug response
fungal virulence
morphogenesis
phospho-switch
thermotolerance
Journal
Frontiers in cellular and infection microbiology
ISSN: 2235-2988
Titre abrégé: Front Cell Infect Microbiol
Pays: Switzerland
ID NLM: 101585359
Informations de publication
Date de publication:
2021
2021
Historique:
received:
04
12
2020
accepted:
24
05
2021
entrez:
13
9
2021
pubmed:
14
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
The highly conserved, ubiquitous molecular chaperone Hsp90 is a key regulator of cellular proteostasis and environmental stress responses. In human pathogenic fungi, which kill more than 1.6 million patients each year worldwide, Hsp90 governs cellular morphogenesis, drug resistance, and virulence. Yet, our understanding of the regulatory mechanisms governing fungal Hsp90 function remains sparse. Post-translational modifications are powerful components of nature's toolbox to regulate protein abundance and function. Phosphorylation in particular is critical in many cellular signaling pathways and errant phosphorylation can have dire consequences for the cell. In the case of Hsp90, phosphorylation affects its stability and governs its interactions with co-chaperones and clients. Thereby modulating the cell's ability to cope with environmental stress.
Identifiants
pubmed: 34513723
doi: 10.3389/fcimb.2021.637836
pmc: PMC8431828
doi:
Substances chimiques
Antifungal Agents
0
HSP90 Heat-Shock Proteins
0
Types de publication
Case Reports
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
637836Subventions
Organisme : Medical Research Council
ID : MR/L018349/1
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Alaalm, Crunden, Butcher, Obst, Whealy, Williamson, O’Brien, Schaffitzel, Ramage, Spencer and Diezmann.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Annu Rev Biochem. 2006;75:271-94
pubmed: 16756493
Nat Protoc. 2015 Jun;10(6):845-58
pubmed: 25950237
Lett Appl Microbiol. 2015 Sep;61(3):238-44
pubmed: 26118969
PLoS Genet. 2012;8(3):e1002562
pubmed: 22438817
Bioinformatics. 2004 Nov 22;20(17):3246-8
pubmed: 15180930
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):386-94
pubmed: 21460457
Clin Infect Dis. 2019 May 17;68(11):1791-1797
pubmed: 30204844
PLoS Pathog. 2011 Sep;7(9):e1002257
pubmed: 21931556
J Biol Chem. 1989 Feb 15;264(5):2431-7
pubmed: 2492519
Mol Cell Biol. 1995 Jul;15(7):3917-25
pubmed: 7791797
Mol Biol Evol. 2018 Jun 1;35(6):1547-1549
pubmed: 29722887
Mol Biol Evol. 2000 Feb;17(2):301-8
pubmed: 10677853
Antimicrob Agents Chemother. 2014;58(4):1889-96
pubmed: 24395240
Eukaryot Cell. 2015 May;14(5):474-85
pubmed: 25750214
Trends Biochem Sci. 2012 Oct;37(10):447-55
pubmed: 22884395
PLoS Pathog. 2009 Jul;5(7):e1000532
pubmed: 19649312
Cell Rep. 2012 Oct 25;2(4):878-88
pubmed: 23041319
Curr Biol. 2009 Apr 28;19(8):621-9
pubmed: 19327993
Bioinformatics. 2014 Nov 15;30(22):3276-8
pubmed: 25095880
Proc Natl Acad Sci U S A. 2009 Feb 24;106(8):2818-23
pubmed: 19196973
PLoS One. 2019 Jan 25;14(1):e0211180
pubmed: 30682149
Infect Immun. 1995 Nov;63(11):4506-14
pubmed: 7591093
Mol Microbiol. 2017 Jul;105(1):46-64
pubmed: 28370450
Nat Commun. 2019 Aug 9;10(1):3626
pubmed: 31399574
BMC Microbiol. 2011 Jul 11;11:162
pubmed: 21745372
Trends Biochem Sci. 2013 May;38(5):253-62
pubmed: 23507089
Mol Biol Cell. 2012 Jan;23(2):268-83
pubmed: 22090345
Nat Commun. 2020 Mar 5;11(1):1219
pubmed: 32139682
Biochim Biophys Acta. 2012 Mar;1823(3):648-55
pubmed: 21856339
Sci Transl Med. 2012 Dec 19;4(165):165rv13
pubmed: 23253612
Mol Cell. 2011 Mar 18;41(6):672-81
pubmed: 21419342
Eukaryot Cell. 2003 Oct;2(5):1053-60
pubmed: 14555488
Acta Biochim Pol. 2005;52(4):947-51
pubmed: 16265593
Nat Commun. 2019 Jan 24;10(1):402
pubmed: 30679438
Mol Cell Biol. 1990 Aug;10(8):4089-99
pubmed: 2196445
Science. 2005 Sep 30;309(5744):2185-9
pubmed: 16195452
J Antimicrob Chemother. 2019 Jan 1;74(1):234-241
pubmed: 30376118
Chemosphere. 2009 Mar;74(9):1165-70
pubmed: 19138785
J Gen Microbiol. 1989 Nov;135(11):3143-52
pubmed: 2693594
BMC Bioinformatics. 2006 Jan 31;7:47
pubmed: 16445868
Acta Crystallogr D Biol Crystallogr. 2010 Apr;66(Pt 4):486-501
pubmed: 20383002
Cell Mol Life Sci. 2009 Jun;66(11-12):1830-9
pubmed: 19387551
Mol Cell Biol. 1989 Sep;9(9):3919-30
pubmed: 2674684
Biochim Biophys Acta Mol Cell Res. 2018 Jun;1865(6):889-897
pubmed: 29563055
Nat Rev Drug Discov. 2002 Apr;1(4):309-15
pubmed: 12120282
Microbiol Spectr. 2017 Apr;5(2):
pubmed: 28387175
Nature. 2006 Apr 20;440(7087):1013-7
pubmed: 16625188
Diagn Microbiol Infect Dis. 2018 May;91(1):93-97
pubmed: 29452993
J Histochem Cytochem. 2004 Nov;52(11):1427-35
pubmed: 15505337
PLoS Biol. 2019 Mar 13;17(3):e2006966
pubmed: 30865631
Microbiology (Reading). 2016 Feb;162(2):309-317
pubmed: 26645478
Appl Microbiol Biotechnol. 2018 Nov;102(22):9731-9743
pubmed: 30121747
Am J Bot. 2011 Mar;98(3):426-38
pubmed: 21613136
Mol Cell. 2012 Feb 24;45(4):517-28
pubmed: 22365831
Ann Clin Lab Sci. 2003 Winter;33(1):86-93
pubmed: 12661902
Nat Methods. 2012 Jul;9(7):671-5
pubmed: 22930834
Mol Microbiol. 2017 Feb;103(4):635-656
pubmed: 27868254
Front Microbiol. 2015 Nov 10;6:1241
pubmed: 26617583
Nucleic Acids Res. 2004 Mar 19;32(5):1792-7
pubmed: 15034147
G3 (Bethesda). 2017 Nov 6;7(11):3797-3808
pubmed: 28951491
J Fungi (Basel). 2017 Oct 18;3(4):
pubmed: 29371573
Mol Microbiol. 2005 Apr;56(2):559-73
pubmed: 15813744
Eukaryot Cell. 2012 Nov;11(11):1324-32
pubmed: 22822234