Accelerated functional brain aging in pre-clinical familial Alzheimer's disease.
Adult
Aged
Aged, 80 and over
Aging
Alzheimer Disease
/ diagnostic imaging
Amyloid beta-Peptides
/ metabolism
Brain
/ diagnostic imaging
Brain Mapping
/ methods
Cognitive Dysfunction
/ diagnostic imaging
Female
Genetic Predisposition to Disease
/ genetics
Humans
Longitudinal Studies
Magnetic Resonance Imaging
/ methods
Male
Middle Aged
Mutation
Positron-Emission Tomography
/ methods
Young Adult
Journal
Nature communications
ISSN: 2041-1723
Titre abrégé: Nat Commun
Pays: England
ID NLM: 101528555
Informations de publication
Date de publication:
09 09 2021
09 09 2021
Historique:
received:
28
05
2020
accepted:
06
08
2021
entrez:
10
9
2021
pubmed:
11
9
2021
medline:
21
10
2021
Statut:
epublish
Résumé
Resting state functional connectivity (rs-fMRI) is impaired early in persons who subsequently develop Alzheimer's disease (AD) dementia. This impairment may be leveraged to aid investigation of the pre-clinical phase of AD. We developed a model that predicts brain age from resting state (rs)-fMRI data, and assessed whether genetic determinants of AD, as well as beta-amyloid (Aβ) pathology, can accelerate brain aging. Using data from 1340 cognitively unimpaired participants between 18-94 years of age from multiple sites, we showed that topological properties of graphs constructed from rs-fMRI can predict chronological age across the lifespan. Application of our predictive model to the context of pre-clinical AD revealed that the pre-symptomatic phase of autosomal dominant AD includes acceleration of functional brain aging. This association was stronger in individuals having significant Aβ pathology.
Identifiants
pubmed: 34504080
doi: 10.1038/s41467-021-25492-9
pii: 10.1038/s41467-021-25492-9
pmc: PMC8429427
doi:
Substances chimiques
Amyloid beta-Peptides
0
Types de publication
Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
5346Subventions
Organisme : NIA NIH HHS
ID : P30 AG059307
Pays : United States
Organisme : NIA NIH HHS
ID : U24 AG021886
Pays : United States
Organisme : NIA NIH HHS
ID : U01 AG024904
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG071514
Pays : United States
Organisme : NIA NIH HHS
ID : UF1 AG032438
Pays : United States
Organisme : NIH HHS
ID : S10 OD025214
Pays : United States
Organisme : NIA NIH HHS
ID : U19 AG032438
Pays : United States
Investigateurs
Michael Weiner
(M)
Howard J Rosen
(HJ)
Bruce L Miller
(BL)
Paul Aisen
(P)
Ronald G Thomas
(RG)
Michael Donohue
(M)
Sarah Walter
(S)
Devon Gessert
(D)
Tamie Sather
(T)
Gus Jiminez
(G)
Ronald Petersen
(R)
Clifford R Jack
(CR)
Matthew Bernstein
(M)
Bret Borowski
(B)
Jeff Gunter
(J)
Matt Senjem
(M)
Prashanthi Vemuri
(P)
David Jones
(D)
Kejal Kantarci
(K)
Chad Ward
(C)
Sara S Mason
(SS)
Colleen S Albers
(CS)
David Knopman
(D)
Kris Johnson
(K)
William Jagust
(W)
Susan Landau
(S)
John Q Trojanowki
(JQ)
Arthur W Toga
(AW)
Karen Crawford
(K)
Scott Neu
(S)
Laurel Beckett
(L)
Danielle Harvey
(D)
Charles DeCarli
(C)
Robert C Green
(RC)
Andrew J Saykin
(AJ)
Tatiana M Foroud
(TM)
Li Shen
(L)
Faber Kelley
(F)
Sungeun Kim
(S)
Kwangsik Nho
(K)
Martin R Farlow
(MR)
Ann Marie Hake
(AM)
Brandy R Matthews
(BR)
Scott Herring
(S)
Cynthia Hunt
(C)
Nigel J Cairns
(NJ)
Erin Householder
(E)
Lisa Taylor Reinwald
(LT)
Leslie M Shaw
(LM)
Steven E Arnold
(SE)
Jason H Karlawish
(JH)
David Wolk
(D)
Enchi Liu
(E)
Tom Montine
(T)
Nick Fox
(N)
Paul Thompson
(P)
Norbert Schuff
(N)
Robert A Koeppe
(RA)
Judith L Heidebrink
(JL)
Joanne L Lord
(JL)
Norm Foster
(N)
Eric M Reiman
(EM)
Kewei Chen
(K)
Adam Fleisher
(A)
Pierre Tariot
(P)
Stephanie Reeder
(S)
Chet Mathis
(C)
Oscar L Lopez
(OL)
MaryAnn Oakley
(M)
Donna M Simpson
(DM)
Virginia Lee
(V)
Magdalena Korecka
(M)
Michal Figurski
(M)
Steven Potkin
(S)
Zaven Kachaturian
(Z)
Richard Frank
(R)
Peter J Snyder
(PJ)
Susan Molchan
(S)
Jeffrey Kaye
(J)
Joseph Quinn
(J)
Betty Lind
(B)
Raina Carter
(R)
Sara Dolen
(S)
Lon S Schneider
(LS)
Sonia Pawluczyk
(S)
Mauricio Beccera
(M)
Liberty Teodoro
(L)
Bryan M Spann
(BM)
James Brewer
(J)
Helen Vanderswag
(H)
Rachelle S Doody
(RS)
Javier Villanueva Meyer
(JV)
Munir Chowdhury
(M)
Susan Rountree
(S)
Mimi Dang
(M)
Yaakov Stern
(Y)
Lawrence S Honig
(LS)
Karen L Bell
(KL)
John Morris
(J)
Beau Ances
(B)
Maria Carroll
(M)
Sue Leon
(S)
Mark A Mintun
(MA)
Stacy Schneider
(S)
Angela OliverNG
(A)
Randall Griffith
(R)
David Clark
(D)
David Geldmacher
(D)
John Brockington
(J)
Erik Roberson
(E)
Hillel Grossman
(H)
Effie Mitsis
(E)
Leyla deToledo-Morrell
(L)
Raj C Shah
(RC)
Ranjan Duara
(R)
Daniel Varon
(D)
Maria T Greig
(MT)
Peggy Roberts
(P)
Marilyn Albert
(M)
Chiadi Onyike
(C)
Daniel D'Agostino
(D)
Stephanie Kielb
(S)
James E Galvin
(JE)
Dana M Pogorelec
(DM)
Brittany Cerbone
(B)
Christina A Michel
(CA)
Henry Rusinek
(H)
Mony J de Leon
(MJ)
Lidia Glodzik
(L)
Susan De Santi
(S)
P Murali Doraiswamy
(PM)
Jeffrey R Petrella
(JR)
Terence Z Wong
(TZ)
Charles D Smith
(CD)
Greg Jicha
(G)
Peter Hardy
(P)
Partha Sinha
(P)
Elizabeth Oates
(E)
Gary Conrad
(G)
Anton P Porsteinsson
(AP)
Bonnie S Goldstein
(BS)
Kim Martin
(K)
Kelly M Makino
(KM)
M Saleem Ismail
(MS)
Connie Brand
(C)
Ruth A Mulnard
(RA)
Gaby Thai
(G)
Catherine Mc Adams Ortiz
(C)
Kyle Womack
(K)
Dana Mathews
(D)
Mary Quiceno
(M)
Ramon Diaz Arrastia
(RD)
Richard King
(R)
Myron Weiner
(M)
Kristen Martin Cook
(KM)
Michael DeVous
(M)
Allan I Levey
(AI)
James J Lah
(JJ)
Janet S Cellar
(JS)
Jeffrey M Burns
(JM)
Heather S Anderson
(HS)
Russell H Swerdlow
(RH)
Liana Apostolova
(L)
Kathleen Tingus
(K)
Ellen Woo
(E)
Daniel H S Silverman
(DHS)
Po H Lu
(PH)
George Bartzokis
(G)
Neill R Graff Radford
(NRG)
Francine ParfittH
(F)
Tracy Kendall
(T)
Heather Johnson
(H)
Christopher H van Dyck
(CH)
Richard E Carson
(RE)
Martha G MacAvoy
(MG)
Howard Chertkow
(H)
Howard Bergman
(H)
Chris Hosein
(C)
Sandra Black
(S)
Bojana Stefanovic
(B)
Curtis Caldwell
(C)
Ging Yuek Robin Hsiung
(GYR)
Howard Feldman
(H)
Benita Mudge
(B)
Michele Assaly Past
(MA)
Andrew Kertesz
(A)
John Rogers
(J)
Dick Trost
(D)
Charles Bernick
(C)
Donna Munic
(D)
Diana Kerwin
(D)
Marek Marsel Mesulam
(MM)
Kristine Lipowski
(K)
Chuang Kuo Wu
(CK)
Nancy Johnson
(N)
Carl Sadowsky
(C)
Walter Martinez
(W)
Teresa Villena
(T)
Raymond Scott Turner
(RS)
Kathleen Johnson
(K)
Brigid Reynolds
(B)
Reisa A Sperling
(RA)
Keith A Johnson
(KA)
Gad Marshall
(G)
Meghan Frey
(M)
Jerome Yesavage
(J)
Joy L Taylor
(JL)
Barton Lane
(B)
Allyson Rosen
(A)
Jared Tinklenberg
(J)
Marwan N Sabbagh
(MN)
Christine M Belden
(CM)
Sandra A Jacobson
(SA)
Sherye A Sirrel
(SA)
Neil Kowall
(N)
Ronald Killiany
(R)
Andrew E Budson
(AE)
Alexander Norbash
(A)
Patricia Lynn Johnson
(PL)
Thomas O Obisesan
(TO)
Saba Wolday
(S)
Joanne Allard
(J)
Alan Lerner
(A)
Paula Ogrocki
(P)
Leon Hudson
(L)
Evan Fletcher
(E)
Owen Carmichael
(O)
John Olichney
(J)
Smita Kittur
(S)
Michael Borrie
(M)
T Y Lee
(TY)
Rob Bartha
(R)
Sterling Johnson
(S)
Sanjay Asthana
(S)
Cynthia M Carlsson
(CM)
Steven G Potkin
(SG)
Adrian Preda
(A)
Dana Nguyen
(D)
Vernice Bates
(V)
Horacio Capote
(H)
Michelle Rainka
(M)
Douglas W Scharre
(DW)
Maria Kataki
(M)
Anahita Adeli
(A)
Earl A Zimmerman
(EA)
Dzintra Celmins
(D)
Alice D Brown
(AD)
Godfrey D Pearlson
(GD)
Karen Blank
(K)
Karen Anderson
(K)
Robert B Santulli
(RB)
Tamar J Kitzmiller
(TJ)
Eben S Schwartz
(ES)
Kaycee M Sinks
(KM)
Jeff D Williamson
(JD)
Pradeep Garg
(P)
Franklin Watkins
(F)
Brian R Ott
(BR)
Henry Querfurth
(H)
Geoffrey Tremont
(G)
Stephen Salloway
(S)
Paul Malloy
(P)
Stephen Correia
(S)
Jacobo Mintzer
(J)
Kenneth Spicer
(K)
David Bachman
(D)
Elizabether Finger
(E)
Stephen Pasternak
(S)
Irina Rachinsky
(I)
Dick Drost
(D)
Nunzio Pomara
(N)
Raymundo Hernando
(R)
Antero Sarrael
(A)
Susan K Schultz
(SK)
Laura L Boles Ponto
(LLB)
Hyungsub Shim
(H)
Karen Elizabeth Smith
(KE)
Norman Relkin
(N)
Gloria Chaing
(G)
Lisa Raudin
(L)
Amanda Smith
(A)
Kristin Fargher
(K)
Balebail Ashok Raj
(BA)
Ricardo Allegri
(R)
Randy Bateman
(R)
Jacob Bechara
(J)
Tammie Benzinger
(T)
Sarah Berman
(S)
Courtney Bodge
(C)
Susan Brandon
(S)
William Bill Brooks
(WB)
Jill Buck
(J)
Virginia Buckles
(V)
Sochenda Chea
(S)
Jasmeer Chhatwal
(J)
Patricio Chrem
(P)
Helena Chui
(H)
Jake Cinco
(J)
Tamara Donahue
(T)
Jane Douglas
(J)
Noelia Edigo
(N)
Nilufer Erekin-Taner
(N)
Anne Fagan
(A)
Marty Farlow
(M)
Colleen Fitzpatrick
(C)
Gigi Flynn
(G)
Erin Franklin
(E)
Hisako Fujii
(H)
Cortaiga Gant
(C)
Samantha Gardener
(S)
Bernardino Ghetti
(B)
Alison Goate
(A)
Jill Goldman
(J)
Brian Gordon
(B)
Neill Graff-Radford
(N)
Julia Gray
(J)
Alexander Groves
(A)
Jason Hassenstab
(J)
Laura Hoechst-Swisher
(L)
David Holtzman
(D)
Russ Hornbeck
(R)
Siri Houeland DiBari
(SH)
Takeshi Ikeuchi
(T)
Snezana Ikonomovic
(S)
Clifford Jack
(C)
Gina Jerome
(G)
Celeste Karch
(C)
Kensaku Kasuga
(K)
Takeshi Kawarabayashi
(T)
William Bill Klunk
(WB)
Robert Koeppe
(R)
Elke Kuder-Buletta
(E)
Christoph Laske
(C)
Jae-Hong Lee
(JH)
Allan Levey
(A)
Ralph Martins
(R)
Neal Scott Mason
(NS)
Colin Masters
(C)
Denise Maue-Dreyfus
(D)
Eric McDade
(E)
Hiroshi Mori
(H)
John Morris
(J)
Akem Nagamatsu
(A)
Katie Neimeyer
(K)
James Noble
(J)
Joanne Norton
(J)
Richard Perrin
(R)
Marc Raichle
(M)
Alan Renton
(A)
John Ringman
(J)
Jee Hoon Roh
(JH)
Hiroyuki Shimada
(H)
Wendy Sigurdson
(W)
Hamid Sohrabi
(H)
Paige Sparks
(P)
Kazushi Suzuki
(K)
Kevin Taddei
(K)
Peter Wang
(P)
Chengjie Xiong
(C)
Xiong Xu
(X)
Pierre Bellec
(P)
Véronique Bohbot
(V)
Mallar Chakravarty
(M)
Louis Collins
(L)
Pierre Etienne
(P)
Alan Evans
(A)
Serge Gauthier
(S)
Rick Hoge
(R)
Yasser Ituria-Medina
(Y)
Vasavan Nair
(V)
Jamie Near
(J)
Natasha Rajah
(N)
Pedro Rosa-Neto
(P)
Christine Tardif
(C)
Jennifer Tremblay-Mercier
(J)
Etienne Vachon-Presseau
(E)
Informations de copyright
© 2021. The Author(s).
Références
Alzheimers Dement. 2018 Jul;14(7):913-924
pubmed: 29601787
Brain. 2015 Jul;138(Pt 7):2020-33
pubmed: 25953778
Neurology. 2020 Sep 15;95(11):e1554-e1564
pubmed: 32759192
Neuroimage. 2010 Jul 1;51(3):1126-39
pubmed: 20226257
N Engl J Med. 2012 Aug 30;367(9):795-804
pubmed: 22784036
Neurobiol Aging. 2014 Apr;35(4):757-68
pubmed: 24216223
Neurology. 1992 Mar;42(3 Pt 1):631-9
pubmed: 1549228
Neurobiol Aging. 2012 Feb;33(2):323-34
pubmed: 20409610
PLoS One. 2016 Jul 13;11(7):e0157514
pubmed: 27410431
Neuroimage. 2013 Jul 15;75:58-67
pubmed: 23501046
JAMA Neurol. 2017 Jul 1;74(7):830-838
pubmed: 28558099
Sci Rep. 2016 Oct 11;6:34853
pubmed: 27725689
Lancet Neurol. 2012 Dec;11(12):1048-56
pubmed: 23137948
Alzheimers Dement. 2015 Jul;11(7):757-71
pubmed: 26194311
Brain. 2018 Apr 1;141(4):1186-1200
pubmed: 29462334
Neurology. 2019 Apr 9;92(15):e1745-e1753
pubmed: 30867271
Neuroimage. 2018 Jul 1;174:57-68
pubmed: 29462724
Front Aging Neurosci. 2018 Aug 22;10:252
pubmed: 30186151
Brain. 2016 Feb;139(Pt 2):547-62
pubmed: 26586695
Nat Commun. 2016 Jun 21;7:11934
pubmed: 27327500
Cereb Cortex. 2008 Aug;18(8):1856-64
pubmed: 18063564
Neurobiol Aging. 2016 Apr;40:138-144
pubmed: 26973113
Ann Neurol. 1993 Mar;33(3):258-66
pubmed: 8498809
Brain. 2011 Jun;134(Pt 6):1635-46
pubmed: 21490054
Proc Natl Acad Sci U S A. 2010 Mar 9;107(10):4734-9
pubmed: 20176931
Neuroimage. 2018 Oct 15;180(Pt A):68-77
pubmed: 28655633
Brain. 2016 Jul;139(Pt 7):1958-70
pubmed: 27190016
Lancet Neurol. 2013 Apr;12(4):357-67
pubmed: 23477989
JAMA Neurol. 2014 Nov;71(11):1379-85
pubmed: 25222039
Science. 2010 Sep 10;329(5997):1358-61
pubmed: 20829489
Proc Natl Acad Sci U S A. 2019 Oct 15;116(42):21213-21218
pubmed: 31575746
Science. 2002 Jul 19;297(5580):353-6
pubmed: 12130773
Lancet Neurol. 2013 Feb;12(2):207-16
pubmed: 23332364
PLoS One. 2013 Jun 27;8(6):e67346
pubmed: 23826273
Nat Aging. 2021 Mar;1(3):295-308
pubmed: 33796868
Alzheimers Dement. 2010 May;6(3):202-11.e7
pubmed: 20451868
Neuroimage. 2017 Dec;163:115-124
pubmed: 28765056
J Magn Reson Imaging. 2008 Apr;27(4):685-91
pubmed: 18302232
Brain Struct Funct. 2018 Jan;223(1):297-305
pubmed: 28815301
JAMA Neurol. 2014 Sep;71(9):1111-22
pubmed: 25069482
Neurology. 2018 Apr 24;90(17):e1452-e1460
pubmed: 29572282
Front Neurol. 2019 Aug 14;10:789
pubmed: 31474922
Neuroimage. 2006 Jul 1;31(3):968-80
pubmed: 16530430
Nat Neurosci. 2019 Oct;22(10):1617-1623
pubmed: 31551603
Neuropsychol Rev. 2014 Sep;24(3):290-9
pubmed: 25146994
Brain. 2018 May 1;141(5):1486-1500
pubmed: 29522171
Front Hum Neurosci. 2015 Jul 16;9:418
pubmed: 26236224
Proc Natl Acad Sci U S A. 2019 Feb 19;116(8):3251-3255
pubmed: 30718410
J Am Geriatr Soc. 2005 Apr;53(4):695-9
pubmed: 15817019
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Neurobiol Aging. 2020 Aug;92:34-42
pubmed: 32380363
Neurology. 2006 Aug 8;67(3):446-52
pubmed: 16894106
Brain. 2018 Jun 1;141(6):1871-1883
pubmed: 29688388
Philos Trans R Soc Lond B Biol Sci. 2001 Aug 29;356(1412):1293-322
pubmed: 11545704
Neuron. 2011 Nov 17;72(4):665-78
pubmed: 22099467
Front Comput Neurosci. 2013 Apr 25;7:38
pubmed: 23630491
Sci Transl Med. 2020 Jan 1;12(524):
pubmed: 31894103
Neuroimage. 2010 Apr 15;50(3):883-92
pubmed: 20070949
Alzheimers Dement. 2019 Apr;15(4):590-597
pubmed: 30819626
Sci Data. 2015 Oct 13;2:150043
pubmed: 26504522
Sci Rep. 2020 Jan 30;10(1):10
pubmed: 32001736
Biol Psychiatry. 2013 Sep 1;74(5):340-7
pubmed: 23290495
Neuroimage. 2017 Mar 1;148:179-188
pubmed: 27890805
Neurology. 2011 Oct 18;77(16):1524-31
pubmed: 21975202
JAMA Neurol. 2020 Jun 1;77(6):735-745
pubmed: 32250387
Hum Brain Mapp. 2017 Aug;38(8):4125-4156
pubmed: 28544076
Neurology. 2019 Jul 9;93(2):72-79
pubmed: 31167933
Alzheimers Dement. 2017 Nov;13(11):1261-1269
pubmed: 28366797
Neuron. 2013 Jan 23;77(2):219-34
pubmed: 23352159
Neuroimage. 2012 Feb 1;59(3):2142-54
pubmed: 22019881
Clin Investig (Lond). 2012 Oct 1;2(10):975-984
pubmed: 23139856
Neurology. 1993 Nov;43(11):2412-4
pubmed: 8232972
Proc Natl Acad Sci U S A. 2004 Mar 30;101(13):4637-42
pubmed: 15070770
Alzheimers Dement. 2011 May;7(3):263-9
pubmed: 21514250
Mol Psychiatry. 2012 May;17(5):471, 549-58
pubmed: 21727896
Neurology. 2013 Aug 20;81(8):736-44
pubmed: 23884042
Neuroimage. 2017 Jan;144(Pt B):262-269
pubmed: 26375206
Lancet Neurol. 2018 Mar;17(3):241-250
pubmed: 29397305
Front Hum Neurosci. 2019 Feb 26;13:62
pubmed: 30863296
Neuron. 2007 Dec 6;56(5):924-35
pubmed: 18054866
J Geriatr Psychiatry Neurol. 2010 Dec;23(4):213-27
pubmed: 21045163
Trends Neurosci. 2017 Dec;40(12):681-690
pubmed: 29074032
Alzheimers Dement. 2011 May;7(3):280-92
pubmed: 21514248
Neuroimage. 2011 Jan 1;54(1):602-10
pubmed: 20705142
Proc IEEE Int Symp Biomed Imaging. 2018 Apr;2018:101-104
pubmed: 30079125