A universal pocket in fatty acyl-AMP ligases ensures redirection of fatty acid pool away from coenzyme A-based activation.
E. coli
acyl carrier protein
biochemistry
chemical biology
coenzyme A
fatty acids
fatty acyl-AMP ligases
nonribosomal peptide synthetases
polyketide synthases
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
07 09 2021
07 09 2021
Historique:
received:
05
05
2021
accepted:
06
09
2021
pubmed:
8
9
2021
medline:
21
10
2021
entrez:
7
9
2021
Statut:
epublish
Résumé
Fatty acyl-AMP ligases (FAALs) channelize fatty acids towards biosynthesis of virulent lipids in mycobacteria and other pharmaceutically or ecologically important polyketides and lipopeptides in other microbes. They do so by bypassing the ubiquitous coenzyme A-dependent activation and rely on the acyl carrier protein-tethered 4'-phosphopantetheine (
Identifiants
pubmed: 34490847
doi: 10.7554/eLife.70067
pii: 70067
pmc: PMC8460268
doi:
pii:
Substances chimiques
Acyl Coenzyme A
0
Bacterial Proteins
0
Fatty Acids
0
Adenosine Monophosphate
415SHH325A
Ligases
EC 6.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Informations de copyright
© 2021, Patil et al.
Déclaration de conflit d'intérêts
GP, SM, SS, KP, SP, ND, SN, MM, BP, RG None, PK none, RS Reviewing editor, eLife
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