SPECT imaging of pulmonary vascular disease in bleomycin-induced lung fibrosis using a vascular endothelium tracer.
Adrenomedullin
/ analogs & derivatives
Animals
Antibiotics, Antineoplastic
/ toxicity
Bleomycin
/ toxicity
Endothelium, Vascular
/ diagnostic imaging
Hypertension, Pulmonary
/ chemically induced
Male
Peptide Fragments
/ metabolism
Pulmonary Fibrosis
/ chemically induced
Radiopharmaceuticals
/ metabolism
Rats
Rats, Wistar
Tomography, Emission-Computed, Single-Photon
/ methods
Adrenomedullin
Molecular imaging
Nuclear medicine
Pulmonary embolism
Pulmonary hypertension
Journal
Respiratory research
ISSN: 1465-993X
Titre abrégé: Respir Res
Pays: England
ID NLM: 101090633
Informations de publication
Date de publication:
04 Sep 2021
04 Sep 2021
Historique:
received:
23
02
2021
accepted:
31
08
2021
entrez:
5
9
2021
pubmed:
6
9
2021
medline:
29
1
2022
Statut:
epublish
Résumé
Pulmonary hypertension (PH) complicating idiopathic pulmonary fibrosis (IPF) is associated to worse outcome. There is a great need for a non-invasive diagnostic modality to detect and evaluate the severity of pulmonary vascular disease (PVD). Rats with selective right lung bleomycin-induced fibrosis were compared to control rats. SPECT imaging was performed after three weeks with The bleomycin group developed preferential right lung fibrosis with remodeling and reduced perfusion as assessed with fluorescent microangiography. These rats developed PH with RV hypertrophy and dysfunction. SPECT imaging with
Sections du résumé
BACKGROUND
BACKGROUND
Pulmonary hypertension (PH) complicating idiopathic pulmonary fibrosis (IPF) is associated to worse outcome. There is a great need for a non-invasive diagnostic modality to detect and evaluate the severity of pulmonary vascular disease (PVD).
METHODS
METHODS
Rats with selective right lung bleomycin-induced fibrosis were compared to control rats. SPECT imaging was performed after three weeks with
RESULTS
RESULTS
The bleomycin group developed preferential right lung fibrosis with remodeling and reduced perfusion as assessed with fluorescent microangiography. These rats developed PH with RV hypertrophy and dysfunction.
CONCLUSIONS
CONCLUSIONS
SPECT imaging with
Identifiants
pubmed: 34481508
doi: 10.1186/s12931-021-01836-3
pii: 10.1186/s12931-021-01836-3
pmc: PMC8418741
doi:
Substances chimiques
Antibiotics, Antineoplastic
0
Peptide Fragments
0
Radiopharmaceuticals
0
adrenomedullin (22-52), glycyl-glycyl-alanyl-glycyl-cysteinyl-(PEG)4-cysteinyl-
0
Bleomycin
11056-06-7
Adrenomedullin
148498-78-6
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
240Informations de copyright
© 2021. The Author(s).
Références
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