Validation of the French 3-year prognostic score for death or lung transplant in the United States cystic fibrosis population.
FEV(1)
Prediction model
Prognosis
Journal
Journal of cystic fibrosis : official journal of the European Cystic Fibrosis Society
ISSN: 1873-5010
Titre abrégé: J Cyst Fibros
Pays: Netherlands
ID NLM: 101128966
Informations de publication
Date de publication:
05 2022
05 2022
Historique:
received:
09
06
2021
revised:
22
07
2021
accepted:
11
08
2021
pubmed:
2
9
2021
medline:
3
6
2022
entrez:
1
9
2021
Statut:
ppublish
Résumé
In 2017, Nkam et al. published a prognostic score to predict death or lung transplant within 3 years among adult cystic fibrosis (CF) patients. Their model was developed using French CF registry data and was subsequently validated in the Canadian CF registry. We evaluated this prognostic score using data from adult patients with CF in the United States (US) CF Foundation Patient registry, combined with lung transplant records from the United Network for Organ Sharing (UNOS) Registry (2013 to 2016) (n=11,542). We found that the prognostic score had a very good discriminative index predicting death or lung transplant in the US CF population (AUC 0.88, 95% CI 0.88-0.89) with an odds ratio (OR) of 2.83 (95% CI 2.69 - 2.97) for each unit increase in the score. However, it did not provide significant additional utility over an FEV
Identifiants
pubmed: 34465539
pii: S1569-1993(21)01349-7
doi: 10.1016/j.jcf.2021.08.008
pmc: PMC8882706
mid: NIHMS1736695
pii:
doi:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
471-474Subventions
Organisme : NHLBI NIH HHS
ID : K23 HL128793
Pays : United States
Organisme : NIDDK NIH HHS
ID : P30 DK089507
Pays : United States
Organisme : NHLBI NIH HHS
ID : UM1 HL119073
Pays : United States
Organisme : NHLBI NIH HHS
ID : U01 HL114589
Pays : United States
Organisme : NHLBI NIH HHS
ID : K23 HL138154
Pays : United States
Organisme : NCATS NIH HHS
ID : UL1 TR000423
Pays : United States
Informations de copyright
Copyright © 2021. Published by Elsevier B.V.
Déclaration de conflit d'intérêts
Declarations of Competing Interest The authors report no conflicts of interest.