The interplay between gray matter and white matter neurodegeneration in subjective cognitive decline.

Adult Aged Cognition Cognitive Dysfunction / diagnostic imaging Cohort Studies Female Gray Matter / diagnostic imaging Humans Magnetic Resonance Imaging Male Middle Aged Neuropsychological Tests Spain White Matter / diagnostic imaging
aging gray matter mediation subjective cognitive decline white matter

Journal

Aging
ISSN: 1945-4589
Titre abrégé: Aging (Albany NY)
Pays: United States
ID NLM: 101508617

Informations de publication

Date de publication:
25 08 2021
Historique:
received: 12 01 2021
accepted: 14 08 2021
pubmed: 26 8 2021
medline: 20 1 2022
entrez: 25 8 2021
Statut: ppublish

Résumé

To investigate the interplay between gray matter (GM) and white matter (WM) neurodegeneration in subjective cognitive decline (SCD), including thickness across the whole cortical mantle, hippocampal volume, and integrity across the whole WM. We included 225 cognitively unimpaired individuals from a community-based cohort. Subjective cognitive complaints were assessed through 9 questions covering amnestic and non-amnestic cognitive domains. In our cohort, 123 individuals endorsed from one to six subjective cognitive complaints (i.e. they fulfilled the diagnostic criteria for SCD), while 102 individuals reported zero complaints. GM neurodegeneration was assessed through measures of cortical thickness across the whole mantle and hippocampal volume. WM neurodegeneration was assessed through measures of mean diffusivity (MD) across the whole WM skeleton. Mediation analysis and multiple linear regression were conducted to investigate the interplay between the measures of GM and WM neurodegeneration. A higher number of complaints was associated with reduced hippocampal volume, cortical thinning in several frontal and temporal areas and the insula, and higher MD across the WM skeleton, with a tendency to spare the occipital lobe. SCD-related cortical thinning and increased MD were associated with each other and jointly contributed to complaints, but the contribution of cortical thinning to the number of complaints was stronger. Neurodegeneration processes affecting the GM and WM seem to be associated with each other in SCD and include brain areas other than those typically targeted by Alzheimer's disease. Our findings suggest that SCD may be a sensitive behavioral marker of heterogeneous brain pathologies in individuals recruited from the community.

Identifiants

DOI: 10.18632/aging.203467 PMID: 34433132 PMC: PMC8436909
pubmed: 34433132
pii: 203467
doi: 10.18632/aging.203467
pmc: PMC8436909
doi:

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

19963-19977

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Auteurs

Nira Cedres (N)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet (KI), Stockholm, Sweden.
Department of Psychology, Sensory Cognitive Interaction Laboratory (SCI-lab), Stockholm University, Stockholm, Sweden.

Patricia Diaz-Galvan (P)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet (KI), Stockholm, Sweden.
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.

Lucio Diaz-Flores (L)

Hospital Universitario de Canarias, La Laguna, Tenerife, Spain.

J-Sebastian Muehlboeck (JS)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet (KI), Stockholm, Sweden.

Yaiza Molina (Y)

Faculty of Health Sciences, University Fernando Pessoa Canarias, Las Palmas de Gran Canaria, Spain.

José Barroso (J)

Faculty of Psychology, University of La Laguna, La Laguna, Tenerife, Spain.

Eric Westman (E)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet (KI), Stockholm, Sweden.
Department of Neuroimaging, Centre for Neuroimaging Sciences, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.

Daniel Ferreira (D)

Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society (NVS), Karolinska Institutet (KI), Stockholm, Sweden.
Department of Radiology, Mayo Clinic, Rochester, MN 55905, USA.
Faculty of Psychology, University of La Laguna, La Laguna, Tenerife, Spain.

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