Influence of muscle fatigue on contractile twitch characteristics in persons with parkinson's disease and older adults: A pilot study.
Evoked contraction
Fatigue
Rate of torque development
Skeletal muscle
Journal
Clinical parkinsonism & related disorders
ISSN: 2590-1125
Titre abrégé: Clin Park Relat Disord
Pays: England
ID NLM: 101761473
Informations de publication
Date de publication:
2021
2021
Historique:
received:
26
03
2021
revised:
02
08
2021
accepted:
03
08
2021
entrez:
25
8
2021
pubmed:
26
8
2021
medline:
26
8
2021
Statut:
epublish
Résumé
It is widely accepted that pathophysiological changes to the central nervous system of persons with Parkinson's disease (PD) result in negative effects on motor function. However, less information is known regarding the pathology of PD on skeletal muscle. The purpose of this study was to determine the effect of a fatiguing isometric knee extension protocol on muscle mechanics using evoked twitch contractions in persons with PD and in non-impaired older adults (OLD). Evoked twitch contractions were examined during a fatiguing protocol in PD (66 ± 9 yr, n = 8) and OLD (65 ± 10 yr, n = 5). Participants performed 5-sec maximal isometric voluntary contractions of the quadriceps femoris with 5-sec rest for 3-min. Every 30-sec during rest intervals, a maximal transcutaneous electrical stimulus was administered to the quadriceps femoris to quantify evoked peak twitch torque (pTT), peak relaxation rate (pRR), and peak rate of torque development (pRTD). A large effect of voluntary fatigue (%decline) was observed ( The rate, not the maximum capacity, of torque generation of the muscle during a fatiguing knee extension protocol was affected by PD. Future studies are warranted to identify the mechanism(s) responsible for the observed differences in skeletal muscle contractile characteristics and potential myofiber distribution variation in PD.
Identifiants
pubmed: 34430844
doi: 10.1016/j.prdoa.2021.100103
pii: S2590-1125(21)00015-3
pmc: PMC8374465
doi:
Types de publication
Journal Article
Langues
eng
Pagination
100103Subventions
Organisme : NICHD NIH HHS
ID : P2C HD086851
Pays : United States
Organisme : NICHD NIH HHS
ID : T32 HD071866
Pays : United States
Informations de copyright
© 2021 The Authors. Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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