pH-Sensitive PEGylated Liposomal Silybin: Synthesis, In Vitro and In Vivo Anti-Tumor Evaluation.

Animals Cell Line, Tumor Doxorubicin Drug Delivery Systems / methods Humans Hydrogen-Ion Concentration Liposomes / chemistry Mice Mice, Inbred BALB C Polyethylene Glycols / chemistry Silybin
4T1 breast cancer Hydrazone bond Silybin Silymarin TAT peptide pH-sensitive liposome

Journal

Journal of pharmaceutical sciences
ISSN: 1520-6017
Titre abrégé: J Pharm Sci
Pays: United States
ID NLM: 2985195R

Informations de publication

Date de publication:
12 2021
Historique:
received: 20 01 2021
revised: 14 08 2021
accepted: 14 08 2021
pubmed: 22 8 2021
medline: 1 3 2022
entrez: 21 8 2021
Statut: ppublish

Résumé

The drug delivery systems improve the efficacy of chemotherapeutics through enhanced targeting and controlled release however, biological barriers of tumor microenvironment greatly impede the penetration of nanomedicine within the tumor. We report herein the fabrication of a PEG-detachable silybin (SLB) pH-sensitive liposome decorated with TAT-peptide. For this, Acyl hydrazide-activated PEG

Identifiants

DOI: 10.1016/j.xphs.2021.08.015 PMID: 34418455
pubmed: 34418455
pii: S0022-3549(21)00416-0
doi: 10.1016/j.xphs.2021.08.015
pii:
doi:

Substances chimiques

Liposomes 0
Polyethylene Glycols 3WJQ0SDW1A
Silybin 4RKY41TBTF
Doxorubicin 80168379AG

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

3919-3928

Informations de copyright

Copyright © 2021 American Pharmacists Association. Published by Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of Competing Interest The authors declare that there are no conflicts of interest.

Auteurs

Fatemeh Gheybi (F)

Department of Medical Biotechnology and Nanotechnology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Seyedeh Hoda Alavizadeh (SH)

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Seyed Mahdi Rezayat (SM)

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran; Department of Pharmacology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Mahdi Hatamipour (M)

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran.

Javad Akhtari (J)

Department of Medical Nanotechnology, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.

Reza Faridi Majidi (R)

Department of Medical Nanotechnology, School of Advanced Technologies in Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Ali Badiee (A)

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran.

Mahmoud Reza Jaafari (MR)

Nanotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran; Department of Pharmaceutical Nanotechnology, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran; Biotechnology Research Center, Pharmaceutical Technology Institute, Mashhad University of Medical Sciences, Mashhad, Iran. Electronic address: JafariMR@mums.ac.ir.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Cellules › Cellules cultivées › Cellules cancéreuses en culture › Lignée cellulaire tumorale › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Glucides › Hétérosides › Aminosides › Anthracyclines › Daunorubicine › Doxorubicine › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Thérapeutique › Traitement médicamenteux › Systèmes de délivrance de médicaments › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Phénomènes chimiques › Concentration en ions d'hydrogène › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomimétiques › Membrane artificielle › Liposomes › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Lignées consanguines de souris › Souris de lignée BALB C › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Technologie, industrie et agriculture › Produits manufacturés › Matériaux biomédicaux et dentaires › Polymères › Polyéthylène glycols › pH-Sensitive PEGylated Liposomal Silybin:...
Recherchemedicale.com › Composés hétérocycliques › Composés hétérocycliques à cycles fusionnés › Composés hétérobicycliques › Benzopyranes › 4H-1-Benzopyran-4-ones › Flavonoïdes › Flavonolignanes › Silymarine › Silibinine › pH-Sensitive PEGylated Liposomal Silybin:...