Impact of excessive alcohol abuse on age prediction using the VISAGE enhanced tool for epigenetic age estimation in blood.
Alcohol abuse
DNA methylation
Epigenetic age prediction
VISAGE enhanced tool for age estimation of DNA from somatic tissues
Journal
International journal of legal medicine
ISSN: 1437-1596
Titre abrégé: Int J Legal Med
Pays: Germany
ID NLM: 9101456
Informations de publication
Date de publication:
Nov 2021
Nov 2021
Historique:
received:
02
03
2021
accepted:
06
07
2021
pubmed:
19
8
2021
medline:
3
3
2022
entrez:
18
8
2021
Statut:
ppublish
Résumé
DNA methylation-based clocks provide the most accurate age estimates with practical implications for clinical and forensic genetics. However, the effects of external factors that may influence the estimates are poorly studied. Here, we evaluated the effect of alcohol consumption on epigenetic age prediction in a cohort of extreme alcohol abusers. Blood samples from deceased alcohol abusers and age- and sex-matched controls were analyzed using the VISAGE enhanced tool for age prediction from somatic tissues that enables examination of 44 CpGs within eight age markers. Significantly altered DNA methylation was recorded for alcohol abusers in MIR29B2CHG. This resulted in a mean predicted age of 1.4 years higher compared to the controls and this trend increased in older individuals. The association of alcohol abuse with epigenetic age acceleration, as determined by the prediction analysis performed based on MIR29B2CHG, was small but significant (β = 0.190; P-value = 0.007). However, the observed alteration in DNA methylation of MIR29B2CHG had a non-significant effect on age estimation with the VISAGE age prediction model. The mean absolute error in the alcohol-abusing cohort was 3.1 years, compared to 3.3 years in the control group. At the same time, upregulation of MIR29B2CHG expression may have a biological function, which merits further studies.
Identifiants
pubmed: 34405265
doi: 10.1007/s00414-021-02665-1
pii: 10.1007/s00414-021-02665-1
pmc: PMC8523459
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2209-2219Subventions
Organisme : European Union's Horizon 2020 Research and Innovation Programme
ID : 740580
Informations de copyright
© 2021. The Author(s).
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