12-year prediction of mild cognitive impairment aided by Alzheimer's brain signatures at mean age 56.

Alzheimer’s disease cortical thickness early prediction mean diffusivity mild cognitive impairment

Journal

Brain communications
ISSN: 2632-1297
Titre abrégé: Brain Commun
Pays: England
ID NLM: 101755125

Informations de publication

Date de publication:
2021
Historique:
received: 11 01 2021
revised: 26 04 2021
accepted: 10 05 2021
entrez: 16 8 2021
pubmed: 17 8 2021
medline: 17 8 2021
Statut: epublish

Résumé

Neuroimaging signatures based on composite scores of cortical thickness and hippocampal volume predict progression from mild cognitive impairment to Alzheimer's disease. However, little is known about the ability of these signatures among cognitively normal adults to predict progression to mild cognitive impairment. Towards that end, a signature sensitive to microstructural changes that may predate macrostructural atrophy should be useful. We hypothesized that: (i) a validated MRI-derived Alzheimer's disease signature based on cortical thickness and hippocampal volume in cognitively normal middle-aged adults would predict progression to mild cognitive impairment; and (ii) a novel grey matter mean diffusivity signature would be a better predictor than the thickness/volume signature. This cohort study was part of the Vietnam Era Twin Study of Aging. Concurrent analyses compared cognitively normal and mild cognitive impairment groups at each of three study waves (

Identifiants

DOI: 10.1093/braincomms/fcab167 PMID: 34396116 PMC: PMC8361427
pubmed: 34396116
doi: 10.1093/braincomms/fcab167
pii: fcab167
pmc: PMC8361427
doi:

Types de publication

Journal Article

Langues

eng

Pagination

fcab167

Subventions

Organisme : NIA NIH HHS
ID : R01 AG022982
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018386
Pays : United States
Organisme : NIA NIH HHS
ID : K08 AG047903
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG018384
Pays : United States
Organisme : NIA NIH HHS
ID : K01 AG063805
Pays : United States
Organisme : NIA NIH HHS
ID : R03 AG046413
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050595
Pays : United States

Informations de copyright

© The Author(s) (2021). Published by Oxford University Press on behalf of the Guarantors of Brain.

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Auteurs

McKenna E Williams (ME)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Jeremy A Elman (JA)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Linda K McEvoy (LK)

Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.

Ole A Andreassen (OA)

NORMENT, KG Jebsen Centre for Psychosis Research, Institute of Clinical Medicine, University of Oslo, Oslo 0316, Norway.
Division of Mental Health and Addiction, Oslo University Hospital, Oslo 0372, Norway.

Anders M Dale (AM)

Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.
Department of Neuroscience, University of California San Diego, La Jolla, CA 92093, USA.

Graham M L Eglit (GML)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Lisa T Eyler (LT)

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Desert Pacific Mental Illness Research Education and Clinical Center, VA San Diego Healthcare System, CA 92093, USA.

Christine Fennema-Notestine (C)

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.

Carol E Franz (CE)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Nathan A Gillespie (NA)

Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23284, USA.

Donald J Hagler (DJ)

Department of Radiology, University of California San Diego, La Jolla, CA 92093, USA.

Sean N Hatton (SN)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Neuroscience, University of California San Diego, La Jolla, CA 92093, USA.

Richard L Hauger (RL)

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA 92093, USA.

Amy J Jak (AJ)

Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
VA San Diego Healthcare System, San Diego, CA 92093, USA.

Mark W Logue (MW)

National Center for PTSD: Behavioral Science Division, VA Boston Healthcare System, Boston, MA 02130, USA.
Department of Psychiatry and the Biomedical Genetics Section, Boston University School of Medicine, Boston, MA 02118, USA.
Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.

Michael J Lyons (MJ)

Department of Psychological and Brain Sciences, Boston University, Boston, MA 02212, USA.

Ruth E McKenzie (RE)

Department of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
School of Education and Social Policy, Merrimack College, North Andover, MA 01845, USA.

Michael C Neale (MC)

Virginia Institute for Psychiatric and Behavior Genetics, Virginia Commonwealth University, Richmond, VA 23284, USA.

Matthew S Panizzon (MS)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Olivia K Puckett (OK)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Chandra A Reynolds (CA)

Department of Psychology, University of California Riverside, Riverside, CA 92521, USA.
ORCID: 0000-0001-6502-7173

Mark Sanderson-Cimino (M)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Joint Doctoral Program in Clinical Psychology, San Diego State University/University of California, San Diego, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Rosemary Toomey (R)

Department of Psychological and Brain Sciences, Boston University, Boston, MA 02212, USA.

Xin M Tu (XM)

Family Medicine and Public Health, University of California San Diego, La Jolla, CA 92093, USA.
ORCID: 0000-0001-6470-980X

Nathan Whitsel (N)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.

Hong Xian (H)

Department of Biostatistics, St. Louis University, St. Louis, MO 63103, USA.

William S Kremen (WS)

Center for Behavior Genetics of Aging, University of California San Diego, La Jolla, CA 92093, USA.
Department of Psychiatry, University of California San Diego, La Jolla, CA 92093, USA.
Center of Excellence for Stress and Mental Health (CESAMH), VA San Diego Healthcare System, San Diego, CA 92093, USA.

Classifications MeSH