Identifying and Avoiding Risk of Bias in Caries Diagnostic Studies.

caries assessment caries detection caries diagnostics caries monitoring clinical studies laboratory studies methodology reference standard

Journal

Journal of clinical medicine
ISSN: 2077-0383
Titre abrégé: J Clin Med
Pays: Switzerland
ID NLM: 101606588

Informations de publication

Date de publication:
22 Jul 2021
Historique:
received: 22 05 2021
revised: 12 07 2021
accepted: 13 07 2021
entrez: 7 8 2021
pubmed: 8 8 2021
medline: 8 8 2021
Statut: epublish

Résumé

Caries diagnostic studies differ with respect to their design, included patients/tooth samples, use of diagnostic and reference methods, calibration, blinding and data reporting. Such heterogeneity makes comparisons between studies difficult and could represent a substantial risk of bias (RoB) when it is not identified. Therefore, the present report aims to describe the development and background of a RoB assessment tool for caries diagnostic studies. The expert group developed and agreed to use a RoB assessment tool during three workshops. Here, existing instruments (e.g., QUADAS 2 and the Joanna Briggs Institute Reviewers' Manual) influenced the hierarchy and phrasing of the signalling questions that were adapted to the specific dental purpose. The tailored RoB assessment tool that was created consists of 16 signalling questions that are organized in four domains. This tool considers the selection/spectrum bias (1), the bias of the index (2) and reference tests (3), and the bias of the study flow and data analysis (4) and can be downloaded from the journal website. This paper explores possible sources of heterogeneity and bias in caries diagnostic studies and summarizes the relevant methodological aspects.

Identifiants

pubmed: 34362007
pii: jcm10153223
doi: 10.3390/jcm10153223
pmc: PMC8347423
pii:
doi:

Types de publication

Journal Article

Langues

eng

Subventions

Organisme : Deutsche Forschungsgemeinschaft
ID : SCHU-3217/1-1

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Auteurs

Jan Kühnisch (J)

Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.

Mila Janjic Rankovic (M)

Department of Orthodontics and Dentofacial Orthopaedics, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.

Svetlana Kapor (S)

Department of Conservative Dentistry and Periodontology, University Hospital, Ludwig-Maximilians University Munich, 80336 Munich, Germany.

Ina Schüler (I)

Department of Orthodontics, Section of Preventive and Paediatric Dentistry, University Hospital, 07743 Jena, Germany.

Felix Krause (F)

Clinic for Operative Dentistry, Periodontology and Preventive Dentistry, University Hospital RWTH Aachen, 52074 Aachen, Germany.

Stavroula Michou (S)

Department of Odontology, University Copenhagen, 2200 Copenhagen, Denmark.

Kim Ekstrand (K)

Department of Odontology, University Copenhagen, 2200 Copenhagen, Denmark.

Florin Eggmann (F)

Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine UZB, University of Basel, 4058 Basel, Switzerland.

Klaus W Neuhaus (KW)

Department of Periodontology, Endodontology and Cariology, University Center for Dental Medicine UZB, University of Basel, 4058 Basel, Switzerland.

Adrian Lussi (A)

School of Dental Medicine, University of Bern, 3012 Bern, Switzerland.
Department of Operative Dentistry and Periodontology, University Medical Centre, 79098 Freiburg, Germany.

Marie-Charlotte Huysmans (MC)

Department of Dentistry, Radboud University Medical Centre, 6525 Nijmegen, The Netherlands.

Classifications MeSH