New Hybrid Compounds Combining Fragments of Usnic Acid and Monoterpenoids for Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibition.
TDP1 inhibitor
inhibiting activity
synergy
terpene
topotecan
tyrosyl-DNA phosphodiesterase 1
usnic acid
Journal
Biomolecules
ISSN: 2218-273X
Titre abrégé: Biomolecules
Pays: Switzerland
ID NLM: 101596414
Informations de publication
Date de publication:
01 07 2021
01 07 2021
Historique:
received:
28
05
2021
revised:
22
06
2021
accepted:
26
06
2021
entrez:
6
8
2021
pubmed:
7
8
2021
medline:
22
9
2021
Statut:
epublish
Résumé
Usnic acid (UA) is a secondary metabolite of lichens that exhibits a wide range of biological activities. Previously, we found that UA derivatives are effective inhibitors of tyrosyl-DNA phosphodiesterase 1 (TDP1). It can remove covalent complex DNA-topoisomerase 1 (TOP1) stabilized by the TOP1 inhibitor topotecan, neutralizing the effect of the drugs. TDP1 removes damage at the 3' end of DNA caused by other anticancer agents. Thus, TDP1 is a promising therapeutic target for the development of drug combinations with topotecan, as well as other drugs for cancer treatment. Ten new UA enamino derivatives with variation in the terpene fragment and substituent of the UA backbone were synthesized and tested as TDP1 inhibitors. Four compounds,
Identifiants
pubmed: 34356597
pii: biom11070973
doi: 10.3390/biom11070973
pmc: PMC8301776
pii:
doi:
Substances chimiques
Benzofurans
0
Monoterpenes
0
Phosphodiesterase Inhibitors
0
usnic acid
0W584PFJ77
Phosphoric Diester Hydrolases
EC 3.1.4.-
TDP1 protein, human
EC 3.1.4.-
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministry of Science and Higher Education of the Russian Federation
ID : 075-15-2020-773
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