Autologous Platelet- and Extracellular Vesicle-Rich Plasma Is an Effective Treatment Modality for Chronic Postoperative Temporal Bone Cavity Inflammation: Randomized Controlled Clinical Trial.
cholesteatoma
extracellular vesicles
mastoidectomy
platelet-rich plasma
quality of life
regenerative medicine
temporal bone
theranostic nanomedicine
Journal
Frontiers in bioengineering and biotechnology
ISSN: 2296-4185
Titre abrégé: Front Bioeng Biotechnol
Pays: Switzerland
ID NLM: 101632513
Informations de publication
Date de publication:
2021
2021
Historique:
received:
07
03
2021
accepted:
10
06
2021
entrez:
26
7
2021
pubmed:
27
7
2021
medline:
27
7
2021
Statut:
epublish
Résumé
To determine the efficacy of autologous platelet- and extracellular vesicle-rich plasma (PVRP) to treat chronic postoperative temporal bone cavity inflammation (CPTBCI) after exhausting surgical and standard conservative therapies. Patients were randomly allocated to treatment with PVRP (PVRP group) or standard conservative methods (control group) in a setting of four once-monthly checkups and subsequent follow-up. The treatment outcome was measured with the Chronic Otitis Media Questionnaire-12 (COMQ-12), CPTBCI focus surface area, and CPTBCI symptom-free time after the fourth checkup. Eleven patients from each group completed the trial; 95% of patients suffered from chronically discharging mastoid cavity (the type of CPTBCI). Within four checkups, the COMQ-12 score decreased statistically significantly in the PVRP group ( Autologous PVRP represents a novel additional and successful treatment modality for a chronically discharging radical mastoid cavity when the surgical and standard conservative treatment methods have been exhausted. https://clinicaltrials.gov (NCT04281901).
Identifiants
pubmed: 34307321
doi: 10.3389/fbioe.2021.677541
pmc: PMC8294456
doi:
Banques de données
ClinicalTrials.gov
['NCT04281901']
Types de publication
Journal Article
Langues
eng
Pagination
677541Informations de copyright
Copyright © 2021 Vozel, Božič, Jeran, Jan, Pajnič, Pađen, Steiner, Kralj-Iglič and Battelino.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Front Bioeng Biotechnol. 2020 Sep 25;8:584050
pubmed: 33102466
Theranostics. 2017 Jan 1;7(1):81-96
pubmed: 28042318
Otol Neurotol. 2015 Jun;36(5):782-7
pubmed: 25730446
Biomed Res Int. 2020 Jan 31;2020:8243865
pubmed: 32076616
PLoS One. 2017 Aug 9;12(8):e0182496
pubmed: 28792974
Otol Neurotol. 2014 Mar;35(3):454-8
pubmed: 24518406
Int J Clin Pract. 2019 Nov;73(11):e13402
pubmed: 31408240
Int J Biol Sci. 2017 Jul 6;13(7):828-834
pubmed: 28808416
Auris Nasus Larynx. 2016 Feb;43(1):62-7
pubmed: 26229017
J Laryngol Otol. 2013 May;127(5):458-62
pubmed: 23552343
Acta Otorhinolaryngol Ital. 2019 Apr;39(2):122-129
pubmed: 31097831
Arthroscopy. 2012 Jul;28(7):998-1009
pubmed: 22738751
Laryngoscope. 2018 May;128(5):E157-E162
pubmed: 29243256
PLoS One. 2019 Jul 29;14(7):e0220392
pubmed: 31356630
J Bone Joint Surg Am. 2017 Oct 18;99(20):1769-1779
pubmed: 29040132
Eur Arch Otorhinolaryngol. 2018 Sep;275(9):2245-2252
pubmed: 29982939
Perfusion. 2007 Jan;22(1):41-50
pubmed: 17633134
Eur Arch Otorhinolaryngol. 2020 Nov;277(11):3103-3109
pubmed: 32476045
Int J Nanomedicine. 2011;6:2737-48
pubmed: 22128248
J Laryngol Otol. 2019 Dec;133(12):1074-1078
pubmed: 31735175
PLoS One. 2018 Jan 11;13(1):e0191093
pubmed: 29324848
Otol Neurotol. 2016 Mar;37(3):248-51
pubmed: 26808557
BMC Ear Nose Throat Disord. 2003 Sep 4;3(1):1
pubmed: 12956889
Turk Arch Otorhinolaryngol. 2018 Mar;56(1):30-35
pubmed: 29988271
Eur Arch Otorhinolaryngol. 2019 Feb;276(2):489-495
pubmed: 30460402
Front Cell Neurosci. 2019 Nov 29;13:530
pubmed: 31849615
Protoplasma. 2014 May;251(3):699-702
pubmed: 24019014
Tissue Eng Part A. 2018 Mar;24(5-6):493-501
pubmed: 28610547
J Voice. 2016 Nov;30(6):731-735
pubmed: 26292799
Tierarztl Prax Ausg G Grosstiere Nutztiere. 2017 Aug 10;45(4):219-225
pubmed: 28745776
Laryngoscope. 2008 Aug;118(8):1427-32
pubmed: 18475206
J Extracell Vesicles. 2015 May 14;4:27066
pubmed: 25979354
PLoS One. 2017 Nov 2;12(11):e0187509
pubmed: 29095890
Eur Arch Otorhinolaryngol. 2021 Feb;278(2):463-470
pubmed: 33009930
Eur Arch Otorhinolaryngol. 2020 Nov;277(11):3037-3043
pubmed: 32424496
Evid Based Spine Care J. 2011 Feb;2(1):7-10
pubmed: 22956930
Zdr Varst. 2020 Jun 25;59(3):120-127
pubmed: 32952712
ACS Nano. 2016 Apr 26;10(4):3886-99
pubmed: 26978483
Ann Intern Med. 2010 Jun 1;152(11):726-32
pubmed: 20335313