3D-2D Image Registration in Virtual Long-Film Imaging: Application to Spinal Deformity Correction.

Intraoperative 2D virtual long-film (VLF) imaging is investigated for 3D guidance and confirmation of the surgical product in spinal deformity correction. Multi-slot-scan geometry (rather than a single-slot "topogram") is exploited to produce parallax views of the scene for accurate 3D colocalization from a single radiograph. The multi-slot approach uses additional angled collimator apertures to form fan-beams with disparate views (parallax) of anatomy and instrumentation and to extend field-of-view beyond the linear motion limits. Combined with a knowledge of surgical implants (pedicle screws and/or spinal rods modeled as "known components"), 3D-2D image registration is used to solve for pose estimates via optimization of image gradient correlation. Experiments were conducted in cadaver studies emulating the system geometry of the O-arm (Medtronic, Minneapolis MN). Experiments demonstrated feasibility of multi-slot VLF and quantified the geometric accuracy of 3D-2D registration using VLF acquisitions. Registration of pedicle screws from a single VLF yielded mean target registration error of (2.0±0.7) mm, comparable to the accuracy of surgical trackers and registration using multiple radiographs (e.g., AP and LAT). 3D-2D registration in a single VLF image offers a promising new solution for image guidance in spinal deformity correction. The ability to accurately resolve pose from a single view absolves workflow challenges of multiple-view registration and suggests application beyond spine surgery, such as reduction of long-bone fractures.