Cord blood index predicts engraftment and early non-relapse mortality in adult patients with single-unit cord blood transplantation.
Journal
Bone marrow transplantation
ISSN: 1476-5365
Titre abrégé: Bone Marrow Transplant
Pays: England
ID NLM: 8702459
Informations de publication
Date de publication:
11 2021
11 2021
Historique:
received:
08
02
2021
accepted:
30
06
2021
revised:
20
06
2021
pubmed:
17
7
2021
medline:
11
3
2022
entrez:
16
7
2021
Statut:
ppublish
Résumé
How to select optimal cord blood (CB) remains an important clinical question. We developed and validated an index of CB engraftment, the cord blood index (CBI), which uses three weighted variables representing cell doses and HLA mismatches. We modeled the neutrophil engraftment time with competing events by random survival forests for competing risks as a function of the predictors: total nucleated cells, CD34, colony-forming units for granulocytes/macrophages, and the number of HLA mismatches at the antigen and allele levels. The CBI defined three groups that had different neutrophil engraftment rates at day 30 (High, 83.7% [95% CI, 79.2-88.1%]; Intermediate, 77.0% [95% CI, 73.7-80.2%]; Low, 68.4% [95% CI, 63.6-73.2%]), platelet engraftment rates at day 60 (High, 70.4% [95% CI, 64.9-75.9%]; Intermediate, 62.3% [95% CI, 58.5-66.0%]; Low, 49.3% [95% CI, 44.2-54.5%]), and non-relapse mortality at day 100 (High, 14.1% [95% CI, 9.9-18.3%]; Intermediate, 16.4% [95% CI, 13.5-19.3%]; Low, 21.3% [95% CI, 17.1-25.5%]). This novel approach is clinically beneficial and can be adopted immediately because it uses easily obtained pre-freeze data of CB.
Identifiants
pubmed: 34267354
doi: 10.1038/s41409-021-01406-7
pii: 10.1038/s41409-021-01406-7
doi:
Substances chimiques
Antigens, CD34
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
2771-2778Investigateurs
G Kondo
(G)
F Ishimaru
(F)
A Ogawa
(A)
M Minemoto
(M)
K Kashiwase
(K)
F Azuma
(F)
M Ito
(M)
N Namba
(N)
H Tsuno
(H)
T Nagai
(T)
K Muroi
(K)
K Nakajima
(K)
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer Nature Limited.
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