Something Old, Something New: Ion Channel Blockers as Potential Anti-Tuberculosis Agents.
Antitubercular Agents
/ pharmacology
Calcium Channel Blockers
/ pharmacology
Drug Design
Drug Resistance, Multiple, Bacterial
/ drug effects
Humans
Ion Channels
/ antagonists & inhibitors
Macrophages
/ drug effects
Mycobacterium tuberculosis
/ drug effects
Potassium Channel Blockers
/ pharmacology
Sodium Channel Blockers
/ pharmacology
Tuberculosis
/ drug therapy
drug-repurposing
efflux pump
host-directed therapies
ion channel blocker
mycobacterium
tuberculosis
Journal
Frontiers in immunology
ISSN: 1664-3224
Titre abrégé: Front Immunol
Pays: Switzerland
ID NLM: 101560960
Informations de publication
Date de publication:
2021
2021
Historique:
received:
08
02
2021
accepted:
24
05
2021
entrez:
12
7
2021
pubmed:
13
7
2021
medline:
26
10
2021
Statut:
epublish
Résumé
Tuberculosis (TB) remains a challenging global health concern and claims more than a million lives every year. We lack an effective vaccine and understanding of what constitutes protective immunity against TB to inform rational vaccine design. Moreover, treatment of TB requires prolonged use of multi-drug regimens and is complicated by problems of compliance and drug resistance. While most
Identifiants
pubmed: 34248944
doi: 10.3389/fimmu.2021.665785
pmc: PMC8264357
doi:
Substances chimiques
Antitubercular Agents
0
Calcium Channel Blockers
0
Ion Channels
0
Potassium Channel Blockers
0
Sodium Channel Blockers
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
665785Subventions
Organisme : Medical Research Council
ID : MR/P020526/1
Pays : United Kingdom
Organisme : Medical Research Council
ID : MR/T008822/1
Pays : United Kingdom
Organisme : Wellcome Trust
ID : 206545/Z/17/Z
Pays : United Kingdom
Informations de copyright
Copyright © 2021 Mitini-Nkhoma, Chimbayo, Mzinza, Mhango, Chirambo, Mandalasi, Lakudzala, Tembo, Jambo and Mwandumba.
Déclaration de conflit d'intérêts
The authors declare that the manuscript was written in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
J Ethnopharmacol. 1996 Jan;50(1):49-53
pubmed: 8778507
Am J Respir Crit Care Med. 2010 Sep 1;182(5):684-92
pubmed: 20442432
EMBO Mol Med. 2014 Dec 22;7(2):127-39
pubmed: 25535254
Autophagy. 2018;14(1):3-21
pubmed: 28980859
Front Pharmacol. 2016 Nov 25;7:456
pubmed: 27932985
Microb Pathog. 2018 Oct;123:368-371
pubmed: 30056107
J Infect Dis. 2016 Nov 1;214(9):1456-1464
pubmed: 27571906
Int J Antimicrob Agents. 2001 Mar;17(3):225-8
pubmed: 11282269
J Med Microbiol. 2007 Aug;56(Pt 8):1047-1051
pubmed: 17644711
Front Cell Neurosci. 2018 Mar 27;12:89
pubmed: 29636667
Thorax. 1995 Feb;50(2):213-4
pubmed: 7701468
Antimicrob Agents Chemother. 2014 Sep;58(9):5567-9
pubmed: 24936590
Adv Nutr. 2016 Jul 15;7(4):706-18
pubmed: 27422505
Br Med J (Clin Res Ed). 1981 Sep 26;283(6295):825-6
pubmed: 6271328
Molecules. 2014 Jun 05;19(6):7327-40
pubmed: 24905603
PLoS One. 2008;3(12):e4009
pubmed: 19104661
BMC Immunol. 2008 Jul 15;9:35
pubmed: 18627610
Annu Rev Immunol. 1995;13:623-53
pubmed: 7612237
Cell. 2007 Dec 14;131(6):1047-58
pubmed: 18083096
PLoS One. 2010 Sep 09;5(9):
pubmed: 20844587
Antimicrob Agents Chemother. 2018 Apr 26;62(5):
pubmed: 29463541
Int J Mol Sci. 2019 Mar 05;20(5):
pubmed: 30841513
J Antimicrob Chemother. 1996 Dec;38(6):1049-53
pubmed: 9023652
Cell. 2019 Sep 5;178(6):1344-1361.e11
pubmed: 31474371
Sci Rep. 2016 Jun 09;6:27540
pubmed: 27277973
PLoS Pathog. 2014 Feb 20;10(2):e1003946
pubmed: 24586159
Virulence. 2019 Dec;10(1):448-459
pubmed: 30322337
Am J Respir Crit Care Med. 2013 Sep 1;188(5):600-7
pubmed: 23805786
Hypertension. 2021 Feb;77(2):328-337
pubmed: 33307850
Naunyn Schmiedebergs Arch Pharmacol. 2013 Jul;386(7):645-50
pubmed: 23564042
PLoS Pathog. 2020 Feb 18;16(2):e1008337
pubmed: 32069330
Drug Discov Ther. 2020 Jul 15;14(3):143-144
pubmed: 32581194
Proc Natl Acad Sci U S A. 2019 Dec 10;:
pubmed: 31822620
Food Sci Nutr. 2018 Oct 26;6(8):2473-2490
pubmed: 30510749
Antimicrob Agents Chemother. 1990 Nov;34(11):2217-22
pubmed: 2127346
Cold Spring Harb Perspect Biol. 2016 Aug 01;8(8):
pubmed: 27481708
J Pharmacol Exp Ther. 1998 Aug;286(2):727-35
pubmed: 9694927
Science. 2015 Mar 13;347(6227):1256-9
pubmed: 25766236
J Biol Chem. 2018 Mar 9;293(10):3747-3757
pubmed: 29358328
Sci Immunol. 2017 Mar;2(9):
pubmed: 28707004
Mol Pharmacol. 2014 Oct;86(4):378-89
pubmed: 25028482
J Med Case Rep. 2015 May 06;9:100
pubmed: 25943363
Antimicrob Agents Chemother. 1993 Nov;37(11):2344-7
pubmed: 8285617
PLoS One. 2016 Feb 26;11(2):e0149326
pubmed: 26919135
PLoS One. 2009;4(4):e5305
pubmed: 19390594
Nat Med. 2007 Apr;13(4):448-54
pubmed: 17293870
Biochem Biophys Res Commun. 1994 Mar 30;199(3):1181-7
pubmed: 7908516
ACS Infect Dis. 2019 Sep 13;5(9):1609-1623
pubmed: 31305993
Tuberc Res Treat. 2020 Nov 20;2020:3767915
pubmed: 33294223
PLoS One. 2013 Apr 25;8(4):e61925
pubmed: 23634218
Mayo Clin Proc. 1995 Mar;70(3):241-6
pubmed: 7861811
Biochim Biophys Acta. 2015 Oct;1848(10 Pt B):2532-46
pubmed: 25450339
Expert Opin Drug Metab Toxicol. 2016;12(1):21-30
pubmed: 26592418
PLoS One. 2008;3(10):e3426
pubmed: 18923677
J Exp Med. 1994 Oct 1;180(4):1499-509
pubmed: 7931080
Am J Respir Cell Mol Biol. 2016 Dec;55(6):837-847
pubmed: 27468130
Pharmacol Res. 2016 Jul;109:101-7
pubmed: 26644208
JAMA Neurol. 2020 Apr 1;77(4):427-434
pubmed: 31930374
Antibiotics (Basel). 2017 Jan 14;6(1):
pubmed: 28098814
BMC Res Notes. 2018 Oct 1;11(1):691
pubmed: 30285907
Sci Transl Med. 2019 Nov 13;11(518):
pubmed: 31723039
Pharmacogenet Genomics. 2013 Apr;23(4):236-41
pubmed: 23407051
Int J Antimicrob Agents. 2017 Jul;50(1):55-62
pubmed: 28506804
Cell Calcium. 2005 Sep-Oct;38(3-4):253-60
pubmed: 16115682
Cold Spring Harb Perspect Med. 2015 Jan 08;5(5):a017822
pubmed: 25573773
Adverse Drug React Toxicol Rev. 2002;21(3):123-41
pubmed: 12298421
J Immunol Res. 2019 Mar 14;2019:9678098
pubmed: 31001564
Oxid Med Cell Longev. 2019 Aug 14;2019:1529520
pubmed: 31485288
Semin Respir Crit Care Med. 2008 Apr;29(2):198-210
pubmed: 18366001
EMBO Rep. 2019 Oct 4;20(10):e47911
pubmed: 31441223
Antimicrob Agents Chemother. 2018 Aug 27;62(9):
pubmed: 30012752
Adv Exp Med Biol. 2013;783:103-20
pubmed: 23468106
Front Cell Infect Microbiol. 2015 Dec 02;5:90
pubmed: 26697414
Eur J Pharmacol. 2010 Mar 25;630(1-3):19-28
pubmed: 20044988
Medicine (Baltimore). 2017 Jul;96(28):e7482
pubmed: 28700490
J Antimicrob Chemother. 2012 Feb;67(2):290-8
pubmed: 22020137
Pharmacol Rep. 2012;64(1):16-23
pubmed: 22580516
Curr Biol. 2016 Jul 11;26(13):R558-R559
pubmed: 27404247
PLoS One. 2014 Mar 03;9(3):e89975
pubmed: 24594979
Autophagy. 2015;11(12):2160-71
pubmed: 26735433
Arch Biochem Biophys. 2019 May 30;667:49-58
pubmed: 31029687
BMC Med. 2016 Jun 15;14:89
pubmed: 27301245
J Immunol. 1999 Nov 1;163(9):5116-24
pubmed: 10528218
Antimicrob Agents Chemother. 2017 Feb 23;61(3):
pubmed: 28052847
Int J Antimicrob Agents. 2019 Jun;53(6):716-723
pubmed: 30825504
J AOAC Int. 2013 Jan-Feb;96(1):155-60
pubmed: 23513971
J Community Hosp Intern Med Perspect. 2018 Oct 15;8(5):311-314
pubmed: 30356994
Int J Infect Dis. 2018 Apr;69:78-84
pubmed: 29501835
Signal Transduct Target Ther. 2017;2:
pubmed: 29158945
Annu Rev Pharmacol Toxicol. 2018 Jan 6;58:271-291
pubmed: 28715978
Antonie Van Leeuwenhoek. 2003;83(1):63-8
pubmed: 12755481
Chemotherapy. 1992;38(6):410-9
pubmed: 1288966
Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):869-74
pubmed: 25561537