Automated Digital Quantification of Pulmonary Fibrosis in Human Histopathology Specimens.

Ashcroft score Hermansky-Pudlak syndrome collagen idiopathic pulmonary fibrosis interstitial lung disease

Journal

Frontiers in medicine
ISSN: 2296-858X
Titre abrégé: Front Med (Lausanne)
Pays: Switzerland
ID NLM: 101648047

Informations de publication

Date de publication:
2021
Historique:
received: 18 09 2020
accepted: 18 05 2021
entrez: 2 7 2021
pubmed: 3 7 2021
medline: 3 7 2021
Statut: epublish

Résumé

Pulmonary fibrosis is characterized by abnormal interstitial extracellular matrix and cellular accumulations. Methods quantifying fibrosis severity in lung histopathology samples are semi-quantitative, subjective, and analyze only portions of sections. We sought to determine whether automated computerized imaging analysis shown to continuously measure fibrosis in mice could also be applied in human samples. A pilot study was conducted to analyze a small number of specimens from patients with Hermansky-Pudlak syndrome pulmonary fibrosis (HPSPF) or idiopathic pulmonary fibrosis (IPF). Digital images of entire lung histological serial sections stained with picrosirius red and alcian blue or anti-CD68 antibody were analyzed using dedicated software to automatically quantify fibrosis, collagen, and macrophage content. Automated fibrosis quantification based on parenchymal tissue density and fibrosis score measurements was compared to pulmonary function values or Ashcroft score. Automated fibrosis quantification of HPSPF lung explants was significantly higher than that of IPF lung explants or biopsies and was also significantly higher in IPF lung explants than in IPF biopsies. A high correlation coefficient was found between some automated quantification measurements and lung function values for the three sample groups. Automated quantification of collagen content in lung sections used for digital image analyses was similar in the three groups. CD68 immunolabeled cell measurements were significantly higher in HPSPF explants than in IPF biopsies. In conclusion, computerized image analysis provides access to accurate, reader-independent pulmonary fibrosis quantification in human histopathology samples. Fibrosis, collagen content, and immunostained cells can be automatically and individually quantified from serial sections. Robust automated digital image analysis of human lung samples enhances the available tools to quantify and study fibrotic lung disease.

Identifiants

pubmed: 34211981
doi: 10.3389/fmed.2021.607720
pmc: PMC8240807
doi:

Types de publication

Journal Article

Langues

eng

Pagination

607720

Informations de copyright

Copyright © 2021 Testa, Jule, Lundh, Bertotti, Merideth, O'Brien, Nathan, Venuto, El-Chemaly, Malicdan and Gochuico.

Déclaration de conflit d'intérêts

YJ was a Co-founder, Co-owner, and Chief Scientific Officer of Biocellvia. KB is an employee of Biocellvia. A patent application related in part to this work was filed. The remaining authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

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Auteurs

Lauren C Testa (LC)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Yvon Jule (Y)

Biocellvia, Marseille, France.

Linnea Lundh (L)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Karine Bertotti (K)

Biocellvia, Marseille, France.

Melissa A Merideth (MA)

Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Kevin J O'Brien (KJ)

Office of the Clinical Director, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Steven D Nathan (SD)

Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States.

Drew C Venuto (DC)

Advanced Lung Disease and Lung Transplant Program, Inova Fairfax Hospital, Falls Church, VA, United States.

Souheil El-Chemaly (S)

Division of Pulmonary and Critical Care Medicine, Brigham and Women's Hospital, Boston, MA, United States.

May Christine V Malicdan (MCV)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.
Undiagnosed Diseases Program, Office of the Director, National Institutes of Health, Bethesda, MD, United States.

Bernadette R Gochuico (BR)

Medical Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD, United States.

Classifications MeSH