Dopaminergic and serotonergic changes in rabbit fetal brain upon repeated gestational exposure to diesel engine exhaust.
Animals
Brain
/ drug effects
Dopamine
/ metabolism
Female
Male
Maternal Exposure
/ adverse effects
Norepinephrine
/ metabolism
Pregnancy
Prenatal Exposure Delayed Effects
/ physiopathology
Rabbits
Serotonin
/ metabolism
Sex Factors
Synaptic Transmission
/ drug effects
Time Factors
Vehicle Emissions
/ toxicity
Airborne pollution
Diesel exhaust
Gestational exposure
Monoaminergic neuromodulation
Neurotoxicity
Journal
Archives of toxicology
ISSN: 1432-0738
Titre abrégé: Arch Toxicol
Pays: Germany
ID NLM: 0417615
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
26
02
2021
accepted:
17
06
2021
pubmed:
1
7
2021
medline:
8
1
2022
entrez:
30
6
2021
Statut:
ppublish
Résumé
Limited studies in humans and in animal models have investigated the neurotoxic risks related to a gestational exposure to diesel exhaust particles (DEP) on the embryonic brain, especially those regarding monoaminergic systems linked to neurocognitive disorders. We previously showed that exposure to DEP alters monoaminergic neurotransmission in fetal olfactory bulbs and modifies tissue morphology along with behavioral consequences at birth in a rabbit model. Given the anatomical and functional connections between olfactory and central brain structures, we further characterized their impacts in brain regions associated with monoaminergic neurotransmission. At gestational day 28 (GD28), fetal rabbit brains were collected from dams exposed by nose-only to either a clean air or filtered DEP for 2 h/day, 5 days/week, from GD3 to GD27. HPLC dosage and histochemical analyses of the main monoaminergic systems, i.e., dopamine (DA), noradrenaline (NA), and serotonin (5-HT) and their metabolites were conducted in microdissected fetal brain regions. DEP exposure increased the level of DA and decreased the dopaminergic metabolites ratios in the prefrontal cortex (PFC), together with sex-specific alterations in the hippocampus (Hp). In addition, HVA level was increased in the temporal cortex (TCx). Serotonin and 5-HIAA levels were decreased in the fetal Hp. However, DEP exposure did not significantly modify NA levels, tyrosine hydroxylase, tryptophan hydroxylase or AChE enzymatic activity in fetal brain. Exposure to DEP during fetal life results in dopaminergic and serotonergic changes in critical brain regions that might lead to detrimental potential short-term neural disturbances as precursors of long-term neurocognitive consequences.
Identifiants
pubmed: 34189592
doi: 10.1007/s00204-021-03110-3
pii: 10.1007/s00204-021-03110-3
doi:
Substances chimiques
Vehicle Emissions
0
Serotonin
333DO1RDJY
Dopamine
VTD58H1Z2X
Norepinephrine
X4W3ENH1CV
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
3085-3099Subventions
Organisme : Agence Nationale de Sécurité Sanitaire de l'Alimentation, de l'Environnement et du Travail
ID : PNREST 2014/1/190
Informations de copyright
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
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