The genetic organization of longitudinal subcortical volumetric change is stable throughout the lifespan.
brain
genetics
human
lifespan
neuroscience
Journal
eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614
Informations de publication
Date de publication:
28 06 2021
28 06 2021
Historique:
received:
12
01
2021
accepted:
26
06
2021
pubmed:
29
6
2021
medline:
9
10
2021
entrez:
28
6
2021
Statut:
epublish
Résumé
Development and aging of the cerebral cortex show similar topographic organization and are governed by the same genes. It is unclear whether the same is true for subcortical regions, which follow fundamentally different ontogenetic and phylogenetic principles. We tested the hypothesis that genetically governed neurodevelopmental processes can be traced throughout life by assessing to which degree brain regions that develop together continue to change together through life. Analyzing over 6000 longitudinal MRIs of the brain, we used graph theory to identify five clusters of coordinated development, indexed as patterns of correlated volumetric change in brain structures. The clusters tended to follow placement along the cranial axis in embryonic brain development, suggesting continuity from prenatal stages, and correlated with cognition. Across independent longitudinal datasets, we demonstrated that developmental clusters were conserved through life. Twin-based genetic correlations revealed distinct sets of genes governing change in each cluster. Single-nucleotide polymorphisms-based analyses of 38,127 cross-sectional MRIs showed a similar pattern of genetic volume-volume correlations. In conclusion, coordination of subcortical change adheres to fundamental principles of lifespan continuity and genetic organization.
Identifiants
pubmed: 34180395
doi: 10.7554/eLife.66466
pii: 66466
pmc: PMC8260220
doi:
pii:
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : European Research Council
ID : 313440
Pays : International
Organisme : EU Horizon 2020
ID : 732592
Organisme : European Research Council
ID : 283634
Pays : International
Organisme : U.S. National Institute on Aging
ID : AG022381
Organisme : California Walnut Commission
ID : NCT01634841
Organisme : Institució Catalana de Recerca i Estudis Avançats
ID : ICREA Academia-2019
Organisme : Federal Ministry of Education and Research
ID : 16SV5537/16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706/01GL1716A/01GL1716B
Organisme : U.S. National Institute on Aging
ID : AG050595
Organisme : the California Walnut Commission
ID : NCT01634841
Organisme : European Research Council
ID : 725025
Pays : International
Organisme : NIA NIH HHS
ID : K01 AG063805
Pays : United States
Organisme : Horizon 2020
ID : 732592
Organisme : Spanish Ministry of Science and Innovation
ID : MICIU/FEDER/RTI2018-095181-B-C21
Organisme : German Federal Ministry of Education and Research
ID : 16SV5537/16SV5837/16SV5538/16SV5536K/01UW0808/01UW0706/01GL1716A/01GL1716B
Organisme : European Research Council
ID : 677804
Pays : International
Organisme : European Research Council
ID : 313440
Pays : International
Organisme : European Research Council
ID : 725025
Pays : International
Organisme : NIA NIH HHS
ID : R01 AG022381
Pays : United States
Organisme : NIA NIH HHS
ID : R01 AG050595
Pays : United States
Informations de copyright
© 2021, Fjell et al.
Déclaration de conflit d'intérêts
AF, HG, YW, IA, DB, AB, SD, JE, CF, AH, TK, RK, WK, SK, SK, UL, DM, AM, LN, MP, CS, ØS, RW, KW No competing interests declared
Références
Neuroimage. 2017 Oct 15;160:73-83
pubmed: 27845257
Neurobiol Aging. 2005 Oct;26(9):1261-70; discussion 1275-8
pubmed: 16005549
Cereb Cortex. 2021 Mar 5;31(4):1953-1969
pubmed: 33236064
Psychol Aging. 2015 Jun;30(2):286-300
pubmed: 25938244
Phys Rev E Stat Nonlin Soft Matter Phys. 2009 Jul;80(1 Pt 2):016118
pubmed: 19658785
Hum Brain Mapp. 2016 Oct;37(10):3669-84
pubmed: 27228371
Hum Brain Mapp. 2017 Sep;38(9):4444-4458
pubmed: 28580697
Neuroimage. 2019 Mar;188:794-806
pubmed: 30472372
Cereb Cortex. 2019 Mar 1;29(3):1369-1381
pubmed: 30590439
Twin Res Hum Genet. 2013 Feb;16(1):399-402
pubmed: 23110957
J Neurosci. 2009 Sep 23;29(38):11772-82
pubmed: 19776264
Neuroimage. 2010 Aug 1;52(1):172-85
pubmed: 20347997
Sci Rep. 2017 Jun 27;7(1):4273
pubmed: 28655911
Cereb Cortex. 2019 Aug 14;29(9):3879-3890
pubmed: 30357317
Proc Natl Acad Sci U S A. 2002 Jun 11;99(12):7821-6
pubmed: 12060727
Gigascience. 2015 Feb 25;4:7
pubmed: 25722852
Brain Stimul. 2014 Mar-Apr;7(2):287-96
pubmed: 24485466
Neuroimage. 2012 Jul 16;61(4):1402-18
pubmed: 22430496
Neuroimage. 2016 May 1;131:48-54
pubmed: 26505299
Int J Epidemiol. 2014 Jun;43(3):703-12
pubmed: 23505255
Behav Genet. 2009 Sep;39(5):472-95
pubmed: 19404731
Neuroimage. 2018 Sep;178:540-551
pubmed: 29860082
Neuron. 2011 Nov 17;72(4):537-44
pubmed: 22099457
Neuroimage. 2020 Oct 15;220:117038
pubmed: 32585343
Am J Hum Biol. 2005 Nov-Dec;17(6):673-89
pubmed: 16254893
Neuroimage. 1999 Feb;9(2):179-94
pubmed: 9931268
Rev Neurosci. 2010;21(3):187-221
pubmed: 20879692
Am J Hum Genet. 2011 Jan 7;88(1):76-82
pubmed: 21167468
Nat Genet. 2019 Nov;51(11):1624-1636
pubmed: 31636452
Neuroimage. 2015 Feb 15;107:107-115
pubmed: 25498430
J Cogn Neurosci. 1993 Spring;5(2):162-76
pubmed: 23972151
Neuroimage. 2010 Sep;52(3):1059-69
pubmed: 19819337
Natl Health Stat Report. 2009 Jul 8;(16):1-31
pubmed: 19697804
Neuron. 2011 Dec 8;72(5):873-84
pubmed: 22153381
Cereb Cortex. 2017 Feb 1;27(2):1125-1136
pubmed: 26656727
Front Aging Neurosci. 2017 Jan 10;8:333
pubmed: 28119602
Proc Natl Acad Sci U S A. 2014 Jan 28;111(4):1592-7
pubmed: 24474784
Nat Med. 1998 Nov;4(11):1313-7
pubmed: 9809557
BMC Neurol. 2014 Oct 14;14:204
pubmed: 25412575
Mol Biol Evol. 2004 Feb;21(2):236-9
pubmed: 14595094
Cereb Cortex. 2017 Feb 1;27(2):1472-1481
pubmed: 28365755
Neuroimage. 2018 May 1;171:256-267
pubmed: 29274746
Neuroimage. 2009 Oct 1;47(4):1545-57
pubmed: 19501655
Cereb Cortex. 2014 Apr;24(4):919-34
pubmed: 23236213
Neurobiol Aging. 2013 Oct;34(10):2239-47
pubmed: 23643484
Neuroimage. 2011 Jun 15;56(4):2068-79
pubmed: 21459148
Neuroimage. 2011 Jul 1;57(1):19-21
pubmed: 21376812
Neuroimage. 2010 Dec;53(4):1181-96
pubmed: 20637289
Cereb Cortex. 2010 Mar;20(3):534-48
pubmed: 19520764
Genome Biol. 2008;9(9):R142
pubmed: 18811952
J Alzheimers Dis. 2014;41(3):779-91
pubmed: 24685630
Gerontology. 2016;62(3):311-5
pubmed: 26820471
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9357-62
pubmed: 27432992
Neuron. 2002 Jan 31;33(3):341-55
pubmed: 11832223
Proc Natl Acad Sci U S A. 2015 Dec 15;112(50):15462-7
pubmed: 26575625
J Neurosci. 2014 Jun 18;34(25):8488-98
pubmed: 24948804
Neurobiol Aging. 2011 May;32(5):916-32
pubmed: 19570593
Neuroimage. 2018 Apr 15;170:332-347
pubmed: 28219775
Neuroimage. 2013 Mar;68:63-74
pubmed: 23246860
Sci Rep. 2012;2:336
pubmed: 22468223
Proc Natl Acad Sci U S A. 2016 Aug 16;113(33):9148-50
pubmed: 27436907
Nat Commun. 2014 Sep 17;5:4932
pubmed: 25230200
Twin Res Hum Genet. 2006 Dec;9(6):1009-22
pubmed: 17254445
Ageing Res Rev. 2020 Dec;64:101184
pubmed: 32992046
Hum Brain Mapp. 2017 Aug;38(8):3771-3790
pubmed: 28548250
Proc Natl Acad Sci U S A. 2013 Oct 15;110(42):17089-94
pubmed: 24082094