Copper-binding anticancer peptides from the piscidin family: an expanded mechanism that encompasses physical and chemical bilayer disruption.


Journal

Scientific reports
ISSN: 2045-2322
Titre abrégé: Sci Rep
Pays: England
ID NLM: 101563288

Informations de publication

Date de publication:
16 06 2021
Historique:
received: 09 02 2021
accepted: 21 05 2021
entrez: 17 6 2021
pubmed: 18 6 2021
medline: 3 11 2021
Statut: epublish

Résumé

In the search for novel broad-spectrum therapeutics to fight chronic infections, inflammation, and cancer, host defense peptides (HDPs) have garnered increasing interest. Characterizing their biologically-active conformations and minimum motifs for function represents a requisite step to developing them into efficacious and safe therapeutics. Here, we demonstrate that metallating HDPs with Cu

Identifiants

pubmed: 34135370
doi: 10.1038/s41598-021-91670-w
pii: 10.1038/s41598-021-91670-w
pmc: PMC8208971
doi:

Substances chimiques

Antineoplastic Agents 0
Cell-Penetrating Peptides 0
Fish Proteins 0
Lipid Bilayers 0
Copper 789U1901C5

Types de publication

Journal Article Research Support, U.S. Gov't, Non-P.H.S.

Langues

eng

Sous-ensembles de citation

IM

Pagination

12620

Références

Toxicology. 2003 Jul 15;189(1-2):147-63
pubmed: 12821289
Sci Rep. 2020 Mar 19;10(1):5045
pubmed: 32193508
Biochim Biophys Acta. 2016 Dec;1863(12):2977-2992
pubmed: 27646922
Ther Deliv. 2012 Aug;3(8):961-79
pubmed: 22946430
Int J Mol Sci. 2015 Sep 18;16(9):22711-34
pubmed: 26393585
Biophys J. 1991 Jan;59(1):174-85
pubmed: 2015382
ACS Chem Biol. 2018 Apr 20;13(4):844-853
pubmed: 29390186
Biochim Biophys Acta. 2000 Nov 10;1469(3):159-95
pubmed: 11063882
Biophys J. 1991 Sep;60(3):568-76
pubmed: 1932548
Int J Mol Sci. 2019 Oct 24;20(21):
pubmed: 31653020
J Mol Biol. 1999 Jul 2;290(1):99-117
pubmed: 10388560
Nature. 2001 Nov 15;414(6861):268-9
pubmed: 11713517
Biointerphases. 2007 Mar;2(1):21-33
pubmed: 20408633
J Contemp Dent Pract. 2019 Apr 1;20(4):403-404
pubmed: 31308267
PLoS One. 2013;8(4):e60462
pubmed: 23577112
Langmuir. 2013 Jul 9;29(27):8645-56
pubmed: 23745652
Drug News Perspect. 2003 Mar;16(2):87-92
pubmed: 12792669
J Antimicrob Chemother. 2007 Dec;60(6):1206-15
pubmed: 17878146
Nat Rev Drug Discov. 2010 Jun;9(6):447-64
pubmed: 20467424
Dis Aquat Organ. 2006 Oct 27;72(3):241-52
pubmed: 17190202
Liver Transpl. 2011 Nov;17 Suppl 3:S34-7
pubmed: 21748845
Drug Discov Today. 2015 Jan;20(1):122-8
pubmed: 25450771
Faraday Discuss. 2013;161:499-513; discussion 563-89
pubmed: 23805755
Nat Rev Drug Discov. 2006 Mar;5(3):219-34
pubmed: 16518375
Annu Rev Pharmacol Toxicol. 2012;52:337-60
pubmed: 22235859
Nat Rev Mol Cell Biol. 2008 Feb;9(2):112-24
pubmed: 18216768
Chemphyschem. 2019 Jan 21;20(2):295-301
pubmed: 30471190
Cell Mol Life Sci. 2005 Apr;62(7-8):784-90
pubmed: 15868403
J Am Chem Soc. 2014 Mar 5;136(9):3491-504
pubmed: 24410116
Nat Chem Biol. 2015 Jan;11(1):9-15
pubmed: 25517383
Dev Comp Immunol. 2008;32(12):1531-8
pubmed: 18582499
J Mol Biol. 1976 Jan 25;100(3):359-78
pubmed: 943549
Science. 2016 Sep 9;353(6304):1147-51
pubmed: 27609891
J Am Chem Soc. 2011 Jun 29;133(25):9912-22
pubmed: 21585196
J Am Chem Soc. 2012 May 9;134(18):7773-9
pubmed: 22548290
Front Chem. 2018 Jun 25;6:244
pubmed: 29988520
Pharmaceuticals (Basel). 2013 May 27;6(6):728-58
pubmed: 24276259
Biochim Biophys Acta. 2008 Oct;1778(10):2041-50
pubmed: 18440299
Curr Opin Oncol. 2001 Jul;13(4):218-23
pubmed: 11429477
Crit Care. 2016 Jun 22;20(1):136
pubmed: 27329228
J Biomed Sci. 2017 Mar 21;24(1):21
pubmed: 28320393
J Membr Biol. 2015 Jun;248(3):455-67
pubmed: 25292264
Sci Rep. 2019 Aug 2;9(1):11282
pubmed: 31375699
Biophys J. 2011 Mar 16;100(6):1455-62
pubmed: 21402027
J Am Chem Soc. 2016 Feb 10;138(5):1584-90
pubmed: 26820910
Sci Rep. 2017 Jan 04;7:39925
pubmed: 28051162
J Am Chem Soc. 2019 Jun 26;141(25):9837-9853
pubmed: 31144503
World J Gastroenterol. 2014 Oct 14;20(38):13930-5
pubmed: 25320529
Zoolog Sci. 2012 May;29(5):327-32
pubmed: 22559967
Biophys J. 2016 Sep 20;111(6):1258-1266
pubmed: 27653484
J Am Chem Soc. 2007 Jul 4;129(26):8353-61
pubmed: 17552522
Biochim Biophys Acta. 2006 Sep;1758(9):1359-72
pubmed: 16815244
Amino Acids. 2013 Feb;44(2):315-20
pubmed: 22914979
PLoS One. 2012;7(11):e50263
pubmed: 23226256
Oncol Rep. 2017 Aug;38(2):637-651
pubmed: 28677775
Technol Cancer Res Treat. 2014 Apr;13(2):177-94
pubmed: 23919392
Dalton Trans. 2016 Jun 21;45(23):9436-45
pubmed: 27184978
EXCLI J. 2018 Jul 25;17:734-752
pubmed: 30190664
Protein Expr Purif. 2014 Oct;102:63-8
pubmed: 25131859
Proteins. 2005 Jan 1;58(1):211-21
pubmed: 15508143
Braz J Med Biol Res. 2013 Jun;46(6):465-85
pubmed: 23828584
Rev Sci Instrum. 2006 Jul;77(7):74301-7430111
pubmed: 21892232
Mol Cancer Ther. 2005 Apr;4(4):612-24
pubmed: 15827335
Biochem Biophys Res Commun. 2015 Jan 2;456(1):446-51
pubmed: 25482446
Biochim Biophys Acta. 2008 Feb;1778(2):357-75
pubmed: 18078805
Biochemistry. 1989 Apr 18;28(8):3421-37
pubmed: 2742845
Antimicrob Agents Chemother. 2016 Apr 22;60(5):2757-64
pubmed: 26902758
Biochimie. 2015 Jun;113:143-55
pubmed: 25891844
J Amino Acids. 2012;2012:967347
pubmed: 23316341
J Biol Chem. 2002 Feb 15;277(7):5030-9
pubmed: 11739390
Breast Cancer Res. 2011 Oct 24;13(5):R102
pubmed: 22023734
Nucleic Acids Res. 2015 Jan;43(Database issue):D837-43
pubmed: 25270878
Eur J Pharmacol. 2009 Dec 25;625(1-3):190-4
pubmed: 19835863
Biochemistry. 2019 Sep 10;58(36):3802-3812
pubmed: 31448597
Biochem J. 1997 Mar 1;322 ( Pt 2):425-33
pubmed: 9065759
Eur J Biochem. 2003 Feb;270(4):675-86
pubmed: 12581207
J Am Chem Soc. 2006 Apr 26;128(16):5308-9
pubmed: 16620079
J Phys Chem Lett. 2021 May 13;12(18):4392-4399
pubmed: 33939920
J Immunol Res. 2015;2015:761820
pubmed: 26568964
Biochim Biophys Acta. 2014 Sep;1838(9):2341-9
pubmed: 24674984
Int J Cancer. 2007 Apr 15;120(8):1721-30
pubmed: 17236204
Antibiotics (Basel). 2020 Jun 18;9(6):
pubmed: 32570779
Mar Drugs. 2010 Apr 14;8(4):1213-62
pubmed: 20479976
Cell Mol Life Sci. 2011 Jul;68(13):2161-76
pubmed: 21573784
J Phys Chem B. 2015 Dec 10;119(49):15235-46
pubmed: 26569483
Virol J. 2019 Jul 31;16(1):95
pubmed: 31366370
Front Microbiol. 2013 Oct 01;4:294
pubmed: 24101917
Oncotarget. 2016 Jun 28;7(26):40329-40347
pubmed: 27248170
Drug Resist Updat. 2018 Nov;41:1-25
pubmed: 30471641
Jpn J Cancer Res. 1999 Apr;90(4):419-24
pubmed: 10363580
Nature. 1978 Jan 12;271(5641):182-4
pubmed: 579650
Philos Trans R Soc Lond B Biol Sci. 2016 May 26;371(1695):
pubmed: 27160602
Biochim Biophys Acta Biomembr. 2020 Jul 1;1862(7):183236
pubmed: 32126226
Ann Clin Lab Sci. 1990 Sep-Oct;20(5):347-52
pubmed: 2256664
J Hematol Oncol. 2013 Feb 25;6:19
pubmed: 23442817
Jpn J Cancer Res. 1997 Feb;88(2):184-90
pubmed: 9119747
Biochemistry. 2007 Mar 27;46(12):3653-63
pubmed: 17328560
Int J Cancer. 2006 Jun 15;118(12):3030-44
pubmed: 16404738
Peptides. 2009 Sep;30(9):1636-42
pubmed: 19539000
Cancer Res. 1983 Feb;43(2):824-8
pubmed: 6293704
Biophys J. 2011 Sep 7;101(5):1086-94
pubmed: 21889445
ChemMedChem. 2014 Aug;9(8):1892-901
pubmed: 24803240
Trends Immunol. 2014 Sep;35(9):443-50
pubmed: 25113635
J Biol Chem. 1997 May 2;272(18):12008-13
pubmed: 9115266
Trends Biotechnol. 2003 Aug;21(8):362-9
pubmed: 12902173
FEBS J. 2017 Nov;284(21):3662-3683
pubmed: 28892294
Int J Nanomedicine. 2016 Nov 15;11:6047-6064
pubmed: 27895479
Biomaterials. 2015 Jun;53:1-11
pubmed: 25890701
Biophys J. 2009 Apr 8;96(7):2734-43
pubmed: 19348756
Biopolymers. 2013 Nov;100(6):572-83
pubmed: 23553602
Front Chem. 2017 Feb 21;5:5
pubmed: 28271058
J Biol Chem. 2019 Dec 6;294(49):18557-18570
pubmed: 31619519
Langmuir. 2004 Feb 17;20(4):1311-6
pubmed: 15803712
Front Pharmacol. 2018 Aug 17;9:922
pubmed: 30174604
Free Radic Res Commun. 1989;6(1):67-75
pubmed: 2722022

Auteurs

Fatih Comert (F)

Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.

Frank Heinrich (F)

Department of Physics, Carnegie Mellon University, Pittsburgh, PA, 15213, USA.
Center for Neutron Research, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA.

Ananda Chowdhury (A)

Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.

Mason Schoeneck (M)

University of Rochester School of Medicine and Dentistry, Rochester, NY, 14620, USA.

Caitlin Darling (C)

Department of Biological Sciences, Clemson University, Clemson, SC, 29634, USA.

Kyle W Anderson (KW)

Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.
Biomolecular Measurement Division, National Institute of Standards and Technology, Gaithersburg, MD, 20899, USA.

M Daben J Libardo (MDJ)

Department of Chemistry and Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.

Alfredo M Angeles-Boza (AM)

Department of Chemistry and Institute of Materials Science, University of Connecticut, Storrs, CT, 06269, USA.

Vitalii Silin (V)

Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA.

Myriam L Cotten (ML)

Department of Applied Science, William and Mary, Williamsburg, VA, 23185, USA. mcotten@wm.edu.

Mihaela Mihailescu (M)

Institute for Bioscience and Biotechnology Research, Rockville, MD, 20850, USA. emihailescu@ibbr.umd.edu.

Articles similaires

[Redispensing of expensive oral anticancer medicines: a practical application].

Lisanne N van Merendonk, Kübra Akgöl, Bastiaan Nuijen
1.00
Humans Antineoplastic Agents Administration, Oral Drug Costs Counterfeit Drugs

Smoking Cessation and Incident Cardiovascular Disease.

Jun Hwan Cho, Seung Yong Shin, Hoseob Kim et al.
1.00
Humans Male Smoking Cessation Cardiovascular Diseases Female
Humans United States Aged Cross-Sectional Studies Medicare Part C
1.00
Humans Yoga Low Back Pain Female Male

Classifications MeSH