Synthesis of
Journal
Organic letters
ISSN: 1523-7052
Titre abrégé: Org Lett
Pays: United States
ID NLM: 100890393
Informations de publication
Date de publication:
16 Jun 2021
16 Jun 2021
Historique:
entrez:
16
6
2021
pubmed:
17
6
2021
medline:
17
6
2021
Statut:
aheadofprint
Résumé
The cubane ring has received intense attention as a 3D benzene isostere and scaffold. Mono- and 1,4-disubstituted cubanes are well-described. Here we report a practical procedure for a direct radical-mediated chlorocarbonylation process initially reported by Bashir-Hashemi, to access a range of 2-substituted 1,4-cubanedicarboxylic ester derivatives. A subsequent regioselective ester hydrolysis to give fully differentiated 1,2,4-trisubstituted cubanes is demonstrated.
Identifiants
pubmed: 34133174
doi: 10.1021/acs.orglett.1c01702
doi:
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM