Altered Gut Microbiota in a Fragile X Syndrome Mouse Model.
autism spectrum disorders
biomarkers
drug development
drug targets
fragile X syndrome
gut microbiota
mouse models
neuroinflammation
Journal
Frontiers in neuroscience
ISSN: 1662-4548
Titre abrégé: Front Neurosci
Pays: Switzerland
ID NLM: 101478481
Informations de publication
Date de publication:
2021
2021
Historique:
received:
13
01
2021
accepted:
06
04
2021
entrez:
14
6
2021
pubmed:
15
6
2021
medline:
15
6
2021
Statut:
epublish
Résumé
The human gut microbiome is the ecosystem of microorganisms that live in the human digestive system. Several studies have related gut microbiome variants to metabolic, immune and nervous system disorders. Fragile X syndrome (FXS) is a neurodevelopmental disorder considered the most common cause of inherited intellectual disability and the leading monogenetic cause of autism. The role of the gut microbiome in FXS remains largely unexplored. Here, we report the results of a gut microbiome analysis using a FXS mouse model and 16S ribosomal RNA gene sequencing. We identified alterations in the fmr1 KO2 gut microbiome associated with different bacterial species, including those in the genera
Identifiants
pubmed: 34121987
doi: 10.3389/fnins.2021.653120
pmc: PMC8190892
doi:
Types de publication
Journal Article
Langues
eng
Pagination
653120Informations de copyright
Copyright © 2021 Altimiras, Garcia, Palacios-García, Hurley, Deacon, González and Cogram.
Déclaration de conflit d'intérêts
The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.
Références
Neurobiol Dis. 2006 Mar;21(3):549-55
pubmed: 16257225
Brain Behav Immun. 2015 Aug;48:186-94
pubmed: 25882912
Nat Rev Microbiol. 2011 Apr;9(4):244-53
pubmed: 21407241
Front Behav Neurosci. 2013 Nov 21;7:172
pubmed: 24312033
Psychopharmacology (Berl). 2014 Mar;231(6):1217-26
pubmed: 24232444
Proc Natl Acad Sci U S A. 2011 Sep 20;108(38):16050-5
pubmed: 21876150
Clin Biochem. 2008 Sep;41(13):1044-8
pubmed: 18582451
Nature. 2012 Jun 13;486(7402):207-14
pubmed: 22699609
Annu Rev Med. 2019 Jan 27;70:167-181
pubmed: 30365357
Dig Dis Sci. 2012 Aug;57(8):2096-102
pubmed: 22535281
Methods Enzymol. 2013;531:371-444
pubmed: 24060131
Lancet Neurol. 2020 Feb;19(2):179-194
pubmed: 31753762
Proc Natl Acad Sci U S A. 2009 Mar 10;106(10):3698-703
pubmed: 19234110
Nat Neurosci. 2006 Oct;9(10):1221-5
pubmed: 17001341
Gut Microbes. 2018 Jul 4;9(4):308-325
pubmed: 29667480
Trends Neurosci. 2013 May;36(5):305-12
pubmed: 23384445
Am J Physiol Gastrointest Liver Physiol. 2012 Jan 1;302(1):G168-75
pubmed: 21940902
Trends Microbiol. 2011 Jul;19(7):349-59
pubmed: 21684749
PeerJ. 2014 Aug 21;2:e545
pubmed: 25177538
Gut Microbes. 2018 Nov 2;9(6):486-496
pubmed: 29723105
J Psychiatry Neurosci. 2009 May;34(3):230-1
pubmed: 19448854
Neurogastroenterol Motil. 2012 May;24(5):405-13
pubmed: 22404222
Nat Rev Neurosci. 2012 Oct;13(10):701-12
pubmed: 22968153
Nat Rev Microbiol. 2012 Nov;10(11):735-42
pubmed: 23000955
Gut Microbes. 2011 Jul-Aug;2(4):256-61
pubmed: 21983070
Nucleic Acids Res. 2018 Jan 4;46(D1):D633-D639
pubmed: 29059334
Pediatrics. 2009 Jan;123(1):378-90
pubmed: 19117905
ISME J. 2012 Mar;6(3):610-8
pubmed: 22134646
Brain Res. 2018 Aug 15;1693(Pt A):24-36
pubmed: 29653083
Microorganisms. 2018 Jul 23;6(3):
pubmed: 30041463
Clin Gastroenterol Hepatol. 2016 Nov;14(11):1602-1611.e5
pubmed: 27266978
Mol Autism. 2016 Sep 01;7(1):37
pubmed: 27594980
Genome Med. 2017 Apr 28;9(1):39
pubmed: 28449715
Sci Rep. 2018 Jun 11;8(1):8889
pubmed: 29892074
Neurotherapeutics. 2019 Jul;16(3):741-760
pubmed: 30815845
PLoS One. 2014 Nov 11;9(11):e112023
pubmed: 25386941
Curr Opin Clin Nutr Metab Care. 2014 Mar;17(2):139-44
pubmed: 24389673
Best Pract Res Clin Gastroenterol. 2017 Dec;31(6):637-642
pubmed: 29566906
BMC Pediatr. 2011 Dec 12;11:111
pubmed: 22151477
Cell. 2016 Dec 1;167(6):1469-1480.e12
pubmed: 27912057
FEMS Microbiol Ecol. 2014 Dec;90(3):543-50
pubmed: 25314312
J Autism Dev Disord. 2000 Oct;30(5):463-9
pubmed: 11098885
Neuropsychopharmacology. 2019 Nov;44(12):2054-2064
pubmed: 31207607
Front Microbiol. 2016 Oct 26;7:1706
pubmed: 27833600
Neurobiol Dis. 2011 Jun;42(3):311-7
pubmed: 21316452
Nature. 2007 Oct 18;449(7164):804-10
pubmed: 17943116
Mol Autism. 2016 Nov 29;7:49
pubmed: 27957319
Biochim Biophys Acta. 2000 Mar 17;1500(3):291-6
pubmed: 10699370
Transl Psychiatry. 2014 Jun 17;4:e400
pubmed: 24937094
Microb Pathog. 2017 May;106:171-181
pubmed: 26875998
Neuron. 2019 Jan 16;101(2):246-259.e6
pubmed: 30522820
Neurosci Biobehav Rev. 2016 Sep;68:563-574
pubmed: 27345143
Neurogastroenterol Motil. 2011 Mar;23(3):187-92
pubmed: 21303428
PLoS One. 2013 Sep 10;8(9):e74963
pubmed: 24040367
Nat Biotechnol. 2013 Sep;31(9):814-21
pubmed: 23975157
Curr Psychiatry Rep. 2013 Feb;15(2):337
pubmed: 23307560
Sci Rep. 2016 Jul 14;6:29681
pubmed: 27411898
FEMS Microbiol Ecol. 2018 Dec 1;94(12):
pubmed: 30239657
PLoS One. 2013 Oct 09;8(10):e76993
pubmed: 24130822
Neuron. 2019 Mar 20;101(6):1070-1088
pubmed: 30897358
Nat Methods. 2010 May;7(5):335-6
pubmed: 20383131
Genome Res. 2009 Dec;19(12):2317-23
pubmed: 19819907
Nat Rev Gastroenterol Hepatol. 2009 May;6(5):306-14
pubmed: 19404271
Mol Autism. 2013 Nov 04;4(1):42
pubmed: 24188502
Dev Psychobiol. 2019 Jul;61(5):752-771
pubmed: 30523646
Microb Ecol Health Dis. 2012 Aug 24;23:
pubmed: 23990817
Front Physiol. 2011 Dec 07;2:94
pubmed: 22162969
Sci Rep. 2018 Sep 18;8(1):13981
pubmed: 30228282
mBio. 2012 Jan 10;3(1):
pubmed: 22233678
Sci Rep. 2017 Mar 28;7:45356
pubmed: 28349974
Intractable Rare Dis Res. 2014 Nov;3(4):118-33
pubmed: 25606362