Factors contributing to persistent disparate outcomes of in vitro fertilization treatment.
Journal
Current opinion in obstetrics & gynecology
ISSN: 1473-656X
Titre abrégé: Curr Opin Obstet Gynecol
Pays: England
ID NLM: 9007264
Informations de publication
Date de publication:
01 08 2021
01 08 2021
Historique:
pubmed:
9
6
2021
medline:
16
10
2021
entrez:
8
6
2021
Statut:
ppublish
Résumé
Disparate healthcare outcomes are ubiquitous and occur across all fields of medicine, specifically for racial and ethnic minorities. Within reproductive health, minority women face disparate access to care, particularly infertility services, poor outcomes of fertility treatment, alarmingly higher rates of maternal morbidity and mortality as well as higher rates of preterm birth, lower live birth rates when they conceive spontaneously or when they conceive with assisted reproductive technology. The objective of this review is to highlight factors contributing to the persistent racial/ethnic disparities in in vitro fertilization (IVF) outcomes. Recent studies document poorer outcomes after IVF treatment. Black women have been shown to have lower live birth rates following IVF treatment for more than 15 years. In an effort to better understand these negative outcomes, scientists and clinicians have investigated possible biological contributing factors including the vaginal microbiome, differences in oocyte quality, embryo viability, endometrial factors, and hormonal differences. Multiple social/cultural factors also play a role including access to care, particularly for people with low income, patient (mis)education, and medical racism/bias.
Identifiants
pubmed: 34101661
doi: 10.1097/GCO.0000000000000726
pii: 00001703-202108000-00014
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
335-342Informations de copyright
Copyright © 2021 Wolters Kluwer Health, Inc. All rights reserved.
Références
Csokmay JM, Hill MJ, Maguire M, et al. undergoing frozen blastocyst transfers? Fertil Steril 2011; 95:89–93.
Feinberg EC, Larsen FW, Catherino WH, et al. Comparison of assisted reproductive technology utilization and outcomes between Caucasian and African American patients in an equal-access-to-care setting. Fertil Steril 2006; 85:888–894.
Langen ES, Shahine LK, Lamb JD, et al. Asian ethnicity and poor outcomes after in vitro fertilization blastocyst transfer. Am J Obstet Gynecol 2010; 115:591–595.
Luke B, Brown MB, Stern JE, et al. Racial and ethnic disparities in assisted reproductive technology pregnancy and live birth rates within body mass index categories. Fertil Steril 2011; 95:1661–1666.
McQueen DB, Schufreider A, Lee SM, et al. Racial disparities in in vitro fertilization outcomes. Fertil Steril 2015; 105:398–402.
Zhou X, McQueen DB, Schufreider, et al. Black recipients of oocyte donation experience lower live birth rates compared with White recipients. Reprod Biomed Online 2020; 40:668–673.
Makhijani RB, Christy AY, Godiwala PN, et al. Black race results in lower live birth rates in frozen thawed blastocyst transfer cycles (FET) an analysis of 7,002 SART FET cycles. Fertil Steril 2020; 114:e51–e52.
Seifer DB, Zackula R, Grainger DA. Trends of racial disparities in assisted reproductive technology outcomes in black women compared with white women: Society for Assisted Reproductive Technology 1999 and 2000 vs. 2004–2006. Fertil Steril 2010; 93:626–635.
Purcel K, Schembri M, Frazier LM, et al. Asian ethnicity is associated with reduced pregnancy outcomes after assisted reproductive technology. Fertil Steril 2007; 8:297–302.
Seifer DB, Frazier LM, Grainger DA. Disparity in assisted reproductive technologies outcomes in black women compared with white women. Fertil Steril 2008; 90:1701–1710.
Fujimoto VY, Luke B, Brown MB, et al. Society for Assisted Reproductive Technology Writing Group. Racial and ethnic disparities in assisted reproductive technology outcomes in the United States. Fertil Steril 2010; 93:382–390.
Baker VL, Luke B, Brown MB, Alvero R, et al. Multivariate analysis of factors affecting probability of pregnancy and live birth with in vitro fertilization: an analysis of the Society for Assisted Reproductive Technology Clinic Outcomes Reporting System. Fertil Steril 2010; 94:1410–1416.
Shapiro AJ, Darmon SK, Barad DH, et al. Effect of race and ethnicity on utilization and outcomes of assisted reproductive technology in the USA. Reprod Biol Endocrinol 2017; 15:1–11.
Sharara FI, McClamrock HD. Difference in in vitro fertilization (IVF) outcome between white and black women in an inner-city, university-based IVF program. Fertil Steril 2000; 73:1170–1173.
Jayaprakasan K, Pandian D, Hopkisson J, et al. Effect of ethnicity on live birth rates after in vitro fetilisation or intracytoplasmic sperm injection treatment. BJOG 2013 2014; 121:300–308.
Seifer D, Burchin C, Wantman, et al. Status of racial disparities between black and white women undergoing assisted reproductive technology in the US. Reprod Biol Endocrinol 2020; 18:113–126.
Craig LB, Weedin EA, Walker WD, et al. Racial and ethnic differences in pregnancy rates following intrauterine insemination with a focus on American Indians. J Racial Ethn Health Disparities 2018; 5:1077–1083.
Liu Y, Hipp HS, Nagy ZP, et al. The effect of donor and recipient race on outcomes of assisted reproduction. Am J Obstetr Gynecol 2021; 224:374–381.
Jain T. Racial disparities and in vitro fertilization (IVF) treatment outcomes: time to close the gap. Reprod Biol Endocrinol 2020; 18:1–2.
Berga SL. Social determinants of infertility: beyond the obvious. Fertil Steril 2016; 105:1459–1460.
Davis DA. Reproducing while Black: the crisis of Black maternal health, obstetric racism and assisted reproductive technology. Reprod Biomed Soc Online 2020; 11:56–64.
Bougie O, Yap MI, Sikora L, et al. Influence of race/ethnicity on prevalence and presentation of endometriosis: a systematic review and meta-analysis. BJOGV 126 2019; 1104–1115.
Hall WJ, Chapman MV, Lee KM, et al. Implicit racial/ethnic bias among healthcare professionals and its influence on health.
Skafte-Holm A, Humaidan P, Bernabeu A, et al. The Association between Vaginal Dysbiosis and Reproductive Outcomes in Sub-Fertile Women Undergoing IVF-Treatment: A Systematic PRISMA Review and Meta-Analysis. Pathogens. 2021 Mar;10(3):295. care outcomes: a systematic review. Am J Public Health 2015; 105:e60–e76.
Vergaro P, Tiscornia G, Barragán, et al. Vaginal microbiota profile at the time of embryo transfer does not affect live birth rate in IVF cycles with donated oocytes. Reprod Biomed Online 2019; 38:883–891.
Babu G, Singaravelu BG, Srikumar R, Reddy SV. Comparative study on the vaginal flora and incidence of asymptomatic vaginosis among healthy women and in women with infertility problems of reproductive age. J Clin Diagn Res 2017; 11:DC18.
Moreno I, Garcia-Grau I, Bau D, et al. The first glimpse of the endometrial microbiota in early pregnancy. Am J Obstetr Gynecol 2020; 222:296–305.
Franasiak JM, Scott RT. Endometrial microbiome. Curr Opin Obstet Gynecol 2017; 29:146–152.
López-Moreno A, Aguilera M. Vaginal probiotics for reproductive health and related dysbiosis: systematic review and meta-analysis. J Clin Med 2021; 10:1461.
Bracewell-Milnes T, Saso S, Nikolaou D, et al. Investigating the effect of an abnormal cervico-vaginal and endometrial microbiome on assisted reproductive technologies: a systematic review. Am J Reprod Immunol 2018; 80:e13037.
Nazem TG, Sekhon L, Lee J, et al. The likelihood of implantation following transfer of a euploid embryo is not correlated with self-reported race. Fertil Steril 2018; 110:e279.
Bodri D, Guillén JJ, López M, et al. Coll O. Racial disparity in oocyte donation outcome: a multiethnic, matched cohort study. Hum Reprod 2010; 25:436–442.
Cooper TG, Noonan E, Von Eckardstein S, et al. World Health Organization reference values for human semen characteristics. Hum Reprod Update 2010; 16:231–245.
Glazer CH, Li S, Zhang CA, et al. Racial and sociodemographic differences of semen parameters among US men undergoing a semen analysis. Urology 2019; 123:126–132.
Povey AC, Clyma JA, McNamee R, et al. Participating Centres of Chaps-uk. Modifiable and nonmodifiable risk factors for poor semen quality: a case-referent study. Hum Reprod 2012; 27:2799–2806.
Punjani N, Nayan M, Jarvi K, et al. The effect of ethnicity on semen analysis and hormones in the infertile patient. Can Urol Assoc J 2020; 14:31.
McCray NL, Young HA, Irwig MS, et al. the association between race, obesity, and sperm quality among men attending a University Physician Practice in Washington, DC. Am J Mens Health 2020; 14:1557988320925985.
Nazem TG, Chang S, Hernandez-Nieto C, et al. Variations in response to ovarian stimulation, embryo development and euploidy rate among women of different racial backgrounds undergoing in vitro fertilization (IVF). Fertil Steril 2018; 110:e278–e279.
Huddleston HG, Rosen MP, Lamb JD, et al. Asian ethnicity in anonymous oocyte donors is associated with increased estradiol levels but comparable recipient pregnancy rates compared with Caucasians. Fertil Steril 2010; 94:2059–2063.
Moon KS, Csokmay JM, Armstrong AY, et al. Elevated estradiol levels in African-American women may explain the reduced live birth rates following assisted reproduction. Fertil Steril 2010; 94:S242.
Willson SF, Bortoletto P, Romanski PA, et al. Reproductive and obstetric outcomes in women of racial minorities 40 and older undergoing IVF with fresh embryo transfer. Reprod Biomed Online 2021; 42:1181–1186.
Hill MJ, Royster IV GD, Taneja M, et al. Does elevated progesterone on day of oocyte maturation play a role in the racial disparities in IVF outcomes? Reprod Biomed Online 2017; 34:154–161.
GoSwami R, GanGopadhyay S, et al. Oestrogen receptor alpha, beta genes and CYP17A gene polymorphism analysis in women with uterine leiomyoma. J Clin Diagnos Res 2021; 15:1–4. 4p.
Mascarenhas M, Kulkarni M, Balen A. Can the ethnic differences in IVF cycle outcome be influenced by the impact of BMI? Hum Fertil 2020; 23:275–281.
Shohat-Tal A, Sen A, Barad DH, et al. Genetics of androgen metabolism in women with infertility and hypoandrogenism. Nat Rev Endocrinol 2015; 11:429.
Stewart EA, Nicholson WK, Bradley L, et al. The burden of uterine fibroids for African-American women: results of a national survey. J Womens Health 2013; 22:807–816.
Gallagher CS, Mäkinen N, Harris HR, et al. Genome-wide association and epidemiological analyses reveal common genetic origins between uterine leiomyomata and endometriosis. Nat Commun 2019; 10:1–11.
Pavone D, Clemenza S, Sorbi F, et al. Epidemiology and risk factors of uterine fibroids. Best Pract Res Clin Obstet Gynaecol 2018; 46:3–11.
Zhai J, Li S, Sen S, et al. Giudice LC. m6A RNA methylation regulators contribute to eutopic endometrium and myometrium dysfunction in adenomyosis. Frontiers in genetics 2020; 11:716.
Donnez J, Dolmans MM. Hormone therapy for intramural myoma-related infertility from ulipristal acetate to GnRH antagonist: a review. Reprod Biomed Online 2020; 41:431–442.
Ikhena DE, Bulun SE. Literature review on the role of uterine fibroids in endometrial function. Reprod Sci 2018; 25:635–643.
Hart R, Khalaf Y, Yeong CT, et al. Taylor A, Braude P. A prospective controlled study of the effect of intramural uterine fibroids on the outcome of assisted conception. Hum Reprod 2001; 16:2411–2417.
Simón C, Gómez C, Cabanillas S, et al. C. A 5-year multicentre randomized controlled trial comparing personalized, frozen and fresh blastocyst transfer in IVF. Reprod Biomed Online 2020; 41:402–415.
Wellons MF, Fujimoto VY, Baker VL, et al. Race matters: a systematic review of racial/ethnic disparity in Society for Assisted Reproductive Technology reported outcomes. Fertil Steril 2012; 98:406–409.