Performance of urine, blood, and integrated metal biomarkers in relation to birth outcomes in a mixture setting.
Manganese
Metals
Prenatal stress
Puerto Rico
Social support
Journal
Environmental research
ISSN: 1096-0953
Titre abrégé: Environ Res
Pays: Netherlands
ID NLM: 0147621
Informations de publication
Date de publication:
09 2021
09 2021
Historique:
received:
08
03
2021
revised:
07
05
2021
accepted:
27
05
2021
pubmed:
8
6
2021
medline:
7
9
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
Studies on the health effects of metal mixtures typically utilize biomarkers measured in a single biological medium, such as blood or urine. However, the ability to evaluate mixture effects are limited by the uncertainty whether a unified medium can fully capture exposure for each metal. Therefore, it is important to compare and assess metal mixtures measured in different media in epidemiology studies. The aim of this study was to examine the mixture predictive performance of urine and blood metal biomarkers and integrated multi-media biomarkers in association with birth outcomes. In our analysis of 847 women from the Puerto Rico PROTECT Cohort, we measured 10 essential and non-essential metals in repeated and paired samples of urine and blood during pregnancy. For each metal, we integrated exposure estimates from paired urine and blood biomarkers into multi-media biomarkers (MMBs), using intraclass-correlation coefficient (ICC) and weighted quantile sum (WQS) approaches. Using Ridge regressions, four separate Environmental risk scores (ERSs) for metals in urine, blood, MMB Pb was the most important contributor of blood ERS as well as the two integrated multi-media biomarker ERSs. Individuals with high ERS (3rd tertile) showed increased odds of preterm birth compared to individuals with low ERS (1st tertile), with 2.8-fold (95% CI, 1.49 to 5.40) for urine (specific gravity corrected); 3.2- fold (95% CI, 1.68 to 6.25) for blood; 3.9-fold (95% CI, 1.72 to 8.66) for multi-media biomarkers composed using ICC; and 5.2-fold (95% CI, 2.34 to 11.42) for multi-media biomarkers composed using WQS. The four ERSs had comparable predictive performances (AUC ranging from 0.64 to 0.68) when urine is examined with specific gravity corrected concentrations. Within a practical metal panel, measuring metals in either urine or blood may be an equally good approach to evaluate the metals as a mixture. Applications in practical study design require validation of these methods with other cohorts, larger panels of metals and within the context of other adverse health effects of interest.
Sections du résumé
BACKGROUND
Studies on the health effects of metal mixtures typically utilize biomarkers measured in a single biological medium, such as blood or urine. However, the ability to evaluate mixture effects are limited by the uncertainty whether a unified medium can fully capture exposure for each metal. Therefore, it is important to compare and assess metal mixtures measured in different media in epidemiology studies.
OBJECTIVES
The aim of this study was to examine the mixture predictive performance of urine and blood metal biomarkers and integrated multi-media biomarkers in association with birth outcomes.
METHODS
In our analysis of 847 women from the Puerto Rico PROTECT Cohort, we measured 10 essential and non-essential metals in repeated and paired samples of urine and blood during pregnancy. For each metal, we integrated exposure estimates from paired urine and blood biomarkers into multi-media biomarkers (MMBs), using intraclass-correlation coefficient (ICC) and weighted quantile sum (WQS) approaches. Using Ridge regressions, four separate Environmental risk scores (ERSs) for metals in urine, blood, MMB
RESULTS
Pb was the most important contributor of blood ERS as well as the two integrated multi-media biomarker ERSs. Individuals with high ERS (3rd tertile) showed increased odds of preterm birth compared to individuals with low ERS (1st tertile), with 2.8-fold (95% CI, 1.49 to 5.40) for urine (specific gravity corrected); 3.2- fold (95% CI, 1.68 to 6.25) for blood; 3.9-fold (95% CI, 1.72 to 8.66) for multi-media biomarkers composed using ICC; and 5.2-fold (95% CI, 2.34 to 11.42) for multi-media biomarkers composed using WQS. The four ERSs had comparable predictive performances (AUC ranging from 0.64 to 0.68) when urine is examined with specific gravity corrected concentrations.
CONCLUSIONS
Within a practical metal panel, measuring metals in either urine or blood may be an equally good approach to evaluate the metals as a mixture. Applications in practical study design require validation of these methods with other cohorts, larger panels of metals and within the context of other adverse health effects of interest.
Identifiants
pubmed: 34097892
pii: S0013-9351(21)00729-5
doi: 10.1016/j.envres.2021.111435
pmc: PMC8403638
mid: NIHMS1713802
pii:
doi:
Substances chimiques
Biomarkers
0
Metals
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Langues
eng
Sous-ensembles de citation
IM
Pagination
111435Subventions
Organisme : NIMHD NIH HHS
ID : U54 MD007600
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES031591
Pays : United States
Organisme : NIEHS NIH HHS
ID : P30 ES017885
Pays : United States
Organisme : NIH HHS
ID : UH3 OD023251
Pays : United States
Organisme : NIEHS NIH HHS
ID : R01 ES032203
Pays : United States
Organisme : NIEHS NIH HHS
ID : P42 ES017198
Pays : United States
Organisme : NIEHS NIH HHS
ID : P50 ES026049
Pays : United States
Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Références
Autoimmun Rev. 2015 Apr;14(4):277-85
pubmed: 25462582
Environ Int. 2018 Dec;121(Pt 1):990-1002
pubmed: 30316544
Reprod Toxicol. 2008 Feb;25(2):219-23
pubmed: 18242051
Environ Int. 2014 Jan;62:1-11
pubmed: 24161445
Int Arch Occup Environ Health. 1981;48(1):71-9
pubmed: 6894292
Environ Int. 2021 Apr;149:106418
pubmed: 33548848
BMC Pregnancy Childbirth. 2019 Mar 29;19(1):107
pubmed: 30922259
Environ Res. 2007 Oct;105(2):256-66
pubmed: 17632096
J Expo Sci Environ Epidemiol. 2009 Mar;19(3):336-42
pubmed: 18841168
Curr Genomics. 2014 Dec;15(6):464-8
pubmed: 25646074
Environ Res. 2014 Jul;132:407-12
pubmed: 24853977
J Toxicol Environ Health A. 2002 Apr 12;65(7):513-21
pubmed: 11939709
Environ Health Perspect. 2016 Jan;124(1):A6-9
pubmed: 26720830
Chemosphere. 2020 Mar;243:125335
pubmed: 31765894
Environ Health Perspect. 2009 Mar;117(3):455-60
pubmed: 19337522
Int J Environ Res Public Health. 2016 May 12;13(5):
pubmed: 27187434
Pediatr Res. 2016 Jan;79(1-2):136-40
pubmed: 26460521
Environ Res. 2020 Feb;181:108832
pubmed: 31810591
Environ Health Perspect. 2020 Nov;128(11):117001
pubmed: 33141601
Toxicol Lett. 2003 Nov 30;145(2):197-207
pubmed: 14581173
Toxicology. 2003 Jul 15;189(1-2):147-63
pubmed: 12821289
Am J Clin Nutr. 2000 May;71(5 Suppl):1218S-25S
pubmed: 10799394
Ann Clin Biochem. 2000 May;37 ( Pt 3):289-97
pubmed: 10817241
BMC Public Health. 2008 Feb 23;8:72
pubmed: 18294394
Environ Epidemiol. 2019 Oct;3(5):
pubmed: 31844832
Environ Health Perspect. 2004 Dec;112(17):1665-70
pubmed: 15579410
Ann Work Expo Health. 2017 Nov 10;61(9):1097-1107
pubmed: 29025087
Environ Health Perspect. 2017 Aug 25;125(8):087019
pubmed: 28858830
J Biol Chem. 1994 Jun 17;269(24):16896-901
pubmed: 8207012
Environ Health. 2016 Jun 07;15(1):65
pubmed: 27266277
Biomarkers. 2005 Mar-Jun;10(2-3):117-26
pubmed: 16076727
Environ Health Perspect. 2020 Sep;128(9):97002
pubmed: 32897104
Environ Res. 2015 Jul;140:430-9
pubmed: 25967284
Environ Int. 2020 Jan;134:105219
pubmed: 31726361
PLoS Med. 2006 Aug;3(8):e311
pubmed: 16942395
Environ Health. 2014 Apr 29;13(1):31
pubmed: 24775401
Environ Res. 2020 Apr;183:109178
pubmed: 32007748
Chemosphere. 2018 Feb;193:1157-1163
pubmed: 29874744
Neurotoxicology. 2018 Jan;64:204-218
pubmed: 28539244
Plant Physiol Biochem. 2012 Apr;53:33-9
pubmed: 22306354
Clin Biochem. 2011 Mar;44(4):275-80
pubmed: 21223959
Neurochem Int. 2013 Apr;62(5):575-94
pubmed: 23266600
Environ Health Perspect. 2005 Feb;113(2):192-200
pubmed: 15687057
Reprod Toxicol. 2010 Jun;29(3):298-305
pubmed: 20096775
Fertil Steril. 2010 Jan;93(1):130-40
pubmed: 18990371
Environ Res. 2021 May;196:110388
pubmed: 33129852
Environ Res. 2019 Dec;179(Pt B):108854
pubmed: 31678726
J Environ Public Health. 2012;2012:713696
pubmed: 22991565
Clin Chem. 1994 Apr;40(4):562-4
pubmed: 8149610
Epidemiology. 2009 May;20(3):367-73
pubmed: 19289966
Environ Res. 2019 Jan;168:118-129
pubmed: 30296639
PLoS One. 2014 Jun 05;9(6):e98632
pubmed: 24901996
Environ Health. 2011 Jan 19;10(1):6
pubmed: 21247448
BMC Bioinformatics. 2011 Mar 17;12:77
pubmed: 21414208
Am Ind Hyg Assoc J. 1993 Oct;54(10):615-27
pubmed: 8237794
J Agric Biol Environ Stat. 2015 Mar;20(1):100-120
pubmed: 30505142
Stat Med. 2000 May 15;19(9):1141-64
pubmed: 10797513
Antioxidants (Basel). 2021 Jan 15;10(1):
pubmed: 33467519
Glob J Health Sci. 2015 Mar 18;7(5):226-32
pubmed: 26156900
Stat Med. 2003 Oct 15;22(19):3089-100
pubmed: 12973789
Transl Psychiatry. 2020 Oct 21;10(1):358
pubmed: 33087698
Lancet. 2014 Sep 6;384(9946):857-68
pubmed: 25209487
Environ Int. 2020 Dec;145:106149
pubmed: 33002701
Environ Health Perspect. 2016 Dec 1;124(12):A227-A229
pubmed: 27905274
Indian J Pharmacol. 2011 May;43(3):246-53
pubmed: 21713085
Plant Physiol. 1998 Oct;118(2):493-504
pubmed: 9765534
Int J Hyg Environ Health. 2013 Nov;216(6):703-9
pubmed: 23491026
Sci Total Environ. 2020 Jul 10;725:138418
pubmed: 32302842
Environ Sci Technol. 2013 Apr 2;47(7):3439-47
pubmed: 23469879
Oxid Med Cell Longev. 2018 Apr 5;2018:7580707
pubmed: 29849912
Toxicol Lett. 2016 Mar 30;246:57-64
pubmed: 26812500
Environ Int. 2021 Jan;146:106312
pubmed: 33395951
Mar Pollut Bull. 2002;45(1-12):218-23
pubmed: 12398388
PLoS One. 2019 Jun 13;14(6):e0217770
pubmed: 31194765
Clin Chem. 2004 May;50(5):924-32
pubmed: 15105350
Cancer Epidemiol Biomarkers Prev. 2005 Apr;14(4):919-24
pubmed: 15824164
Environ Int. 2018 Dec;121(Pt 1):582-590
pubmed: 30300816
Environ Int. 2020 May;138:105606
pubmed: 32179314
Endocr Rev. 2009 Jun;30(4):293-342
pubmed: 19502515
Int J Hyg Environ Health. 2018 Jul;221(6):876-882
pubmed: 29886104
Pharmacol Res. 1997 Oct;36(4):285-92
pubmed: 9425617
J Cell Biochem. 2018 Jan;119(1):157-184
pubmed: 28643849
J Nutr. 2003 Mar;133(3):817S-827S
pubmed: 12612160
Environ Health Perspect. 2005 Dec;113(12):1669-74
pubmed: 16330345
Int J Hyg Environ Health. 2015 Mar;218(2):212-9
pubmed: 25435060
Environ Res. 2019 Apr;171:444-451
pubmed: 30735952
Am J Ind Med. 2007 Oct;50(10):712-9
pubmed: 17492658
Curr Opin HIV AIDS. 2010 Nov;5(6):463-6
pubmed: 20978388
Environ Int. 2019 Nov;132:105099
pubmed: 31430608
J Obstet Gynaecol Br Emp. 1963 Jun;70:402-7
pubmed: 13956023
Environ Int. 2020 Apr;137:105580
pubmed: 32078870
Environ Int. 2019 Oct;131:104993
pubmed: 31326826
Environ Epidemiol. 2020 Apr;4(2):
pubmed: 32201854
Adv Chronic Kidney Dis. 2013 May;20(3):209-14
pubmed: 23928384
Environ Res. 2004 Nov;96(3):338-44
pubmed: 15364602
Antioxid Redox Signal. 2013 Sep 20;19(9):933-44
pubmed: 23249283
Cancer Epidemiol Biomarkers Prev. 2005 Mar;14(3):705-8
pubmed: 15767353
Environ Res. 2014 Jul;132:226-32
pubmed: 24815335
J Appl Toxicol. 2015 Jun;35(6):551-72
pubmed: 25809475
Biometals. 2004 Dec;17(6):735-43
pubmed: 15689116
Environ Health. 2017 Sep 26;16(1):102
pubmed: 28950902
BMC Public Health. 2017 Apr 24;17(1):354
pubmed: 28438148
Environ Res. 2019 Feb;169:41-51
pubmed: 30412856
Environ Res. 2020 Apr;183:109148
pubmed: 32004829