SARS-CoV-2 virion physicochemical characteristics pertinent to abiotic substrate attachment.
Adsorption of spike protein
Charge distribution over spike protein
Receptor attachment of spike protein
SARS-CoV-2 virion
Spike protein
Structure of SARS-CoV-2 virion
Journal
Current opinion in colloid & interface science
ISSN: 1359-0294
Titre abrégé: Curr Opin Colloid Interface Sci
Pays: England
ID NLM: 9614964
Informations de publication
Date de publication:
Oct 2021
Oct 2021
Historique:
pubmed:
8
6
2021
medline:
8
6
2021
entrez:
7
6
2021
Statut:
ppublish
Résumé
The structure, size, and main physicochemical characteristics of the SARS-CoV-2 virion with the spike transmembrane protein corona were discussed. Using these data, diffusion coefficients of the virion in aqueous media and in air were calculated. The structure and dimensions of the spike protein derived from molecular dynamic modeling and thorough cryo-electron microscopy measurements were also analyzed. The charge distribution over the molecule was calculated and shown to be largely heterogeneous. Although the stalk part is negatively charged, the top part of the spike molecule, especially the receptor binding domain, remains positively charged for a broad range of pH. It is underlined that such a charge distribution promotes the spike corona stability and enhances the virion attachment to receptors and surfaces, mostly negatively charged. The review is completed by the analysis of experimental data pertinent to the spike protein adsorption at abiotic surfaces comprising nanoparticle carrier particles. It is argued that these theoretical and experimental data can be used for developing quantitative models of virus attachment to surfaces, facilitating adequate analysis of future experimental results.
Identifiants
pubmed: 34093061
doi: 10.1016/j.cocis.2021.101466
pii: S1359-0294(21)00050-9
pmc: PMC8169569
doi:
Types de publication
Journal Article
Review
Langues
eng
Pagination
101466Informations de copyright
© 2021 Published by Elsevier Ltd.
Déclaration de conflit d'intérêts
The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
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