Distinct Concentration-Dependent Molecular Pathways Regulate Bone Cell Responses to Cobalt and Chromium Exposure from Joint Replacement Prostheses.


Journal

International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791

Informations de publication

Date de publication:
14 May 2021
Historique:
received: 09 04 2021
revised: 07 05 2021
accepted: 08 05 2021
entrez: 2 6 2021
pubmed: 3 6 2021
medline: 3 7 2021
Statut: epublish

Résumé

Systemic cobalt (Co) and chromium (Cr) concentrations may be elevated in patients with metal joint replacement prostheses. Several studies have highlighted the detrimental effects of this exposure on bone cells in vitro, but the underlying mechanisms remain unclear. In this study, we use whole-genome microarrays to comprehensively assess gene expression in primary human osteoblasts, osteoclast precursors and mature resorbing osteoclasts following exposure to clinically relevant circulating versus local periprosthetic tissue concentrations of Co

Identifiants

pubmed: 34069294
pii: ijms22105225
doi: 10.3390/ijms22105225
pmc: PMC8156984
pii:
doi:

Substances chimiques

Chromium 0R0008Q3JB
Cobalt 3G0H8C9362

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : Orthopaedic Research UK
ID : 517

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Auteurs

Karan M Shah (KM)

The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, UK.

Mark J Dunning (MJ)

Sheffield Bioinformatics Core, The University of Sheffield, 385a Glossop Rd, Sheffield S10 2HQ, UK.

Alison Gartland (A)

The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, UK.

J Mark Wilkinson (JM)

The Mellanby Centre for Musculoskeletal Research, Department of Oncology and Metabolism, The University of Sheffield, Beech Hill Rd, Sheffield S10 2RX, UK.

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Classifications MeSH