Successful Cord Blood Transplantation for Idiopathic CD4+ Lymphocytopenia.
CD4-Positive T-Lymphocytes
/ cytology
Cord Blood Stem Cell Transplantation
Female
Hepatectomy
Humans
Liver Abscess
/ etiology
Lymphocyte Count
Lymphopenia
/ diagnosis
Middle Aged
Mycobacterium avium Complex
/ pathogenicity
Neutrophils
/ transplantation
Tomography, X-Ray Computed
Whole-Body Irradiation
Cord blood transplantation
Idiopathic CD4+ lymphocytopenia
Liver abscess
Mycobacterium avium complex
Reduced-intensity conditioning regimen
Journal
Acta haematologica
ISSN: 1421-9662
Titre abrégé: Acta Haematol
Pays: Switzerland
ID NLM: 0141053
Informations de publication
Date de publication:
Historique:
received:
21
11
2020
accepted:
04
04
2021
pubmed:
2
6
2021
medline:
15
12
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
Idiopathic CD4+ lymphocytopenia (ICL) is the depletion of CD4+ lymphocytes to <300 cells/mm3 without human immunodeficiency virus infection or other causes of lymphocytopenia. ICL causes fatal infections; its etiology remains unclear and it lacks consensus regarding therapeutic options. We report the first patient with ICL who had a successful clinical course following a cord blood transplant (CBT). A 45-year-old woman was diagnosed with ICL and underwent partial hepatectomy for an abscess caused by the Mycobacterium avium complex. No specific gene alterations were detected through next generation sequencing-based evaluation. Following a reduced-intensity conditioning (RIC) regimen consisting of fludarabine, busulfan, and 4 Gy total body irradiation, a single-unit CBT was performed. Neutrophils were engrafted on day +14. CD4+ lymphocyte counts increased to over 300 cells/mm3 on day +436. After 75 months, she was alive without any sequelae. CBT with an RIC regimen could be a curable treatment option for ICL.
Identifiants
pubmed: 34062545
pii: 000516347
doi: 10.1159/000516347
doi:
Types de publication
Case Reports
Langues
eng
Sous-ensembles de citation
IM
Pagination
698-705Informations de copyright
© 2021 S. Karger AG, Basel.