Comprehensive expression pattern of kin of irregular chiasm-like 3 in the adult mouse brain.
Autism spectrum disorder
Cerebellum
Cerebral cortex
Hippocampus
Immunoglobulin superfamily
Olfactory bulb
Journal
Biochemical and biophysical research communications
ISSN: 1090-2104
Titre abrégé: Biochem Biophys Res Commun
Pays: United States
ID NLM: 0372516
Informations de publication
Date de publication:
23 07 2021
23 07 2021
Historique:
received:
16
04
2021
accepted:
18
05
2021
pubmed:
2
6
2021
medline:
12
11
2021
entrez:
1
6
2021
Statut:
ppublish
Résumé
Kin of irregular chiasm-like 3 (Kirrel3), a member of the immunoglobulin superfamily, is expressed in the central nervous system during development and in adulthood. It has been reported that Kirrel3 is involved in the axonal fasciculation in the olfactory bulb, the neuronal migration in the pontine nucleus, and the synapse formation in the hippocampal neurons in mice. Although KIRREL3 mutations have been implicated in autism spectrum disorder and intellectual disability in humans, the comprehensive expression pattern of Kirrel3 in the adult brain is not fully understood. To better visualize Kirrel3 expression pattern and to gain insight into the role of Kirrel3 in the brain, we investigated the expression of Kirrel3 in the adult brain of Kirrel3-heterozygous (Kirrel3
Identifiants
pubmed: 34062388
pii: S0006-291X(21)00843-3
doi: 10.1016/j.bbrc.2021.05.063
pii:
doi:
Substances chimiques
Kirrel3 protein, mouse
0
Membrane Proteins
0
beta-Galactosidase
EC 3.2.1.23
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
66-72Informations de copyright
Copyright © 2021 Elsevier Inc. All rights reserved.
Déclaration de conflit d'intérêts
Declaration of competing interest The authors declare no conflicts of interest.